MolNFT v1 · #72728 · protein

Nucleotide binding domain of human ABCB6 (apo structure)

3NH6 · ATP-binding cassette sub-family B member 6, mitochondrial: “Nucleotide binding domain of human ABCB6 (apo structure)”. X-ray diffraction, 4 pockets (best druggability 0.53). MolNFT v1 #72728 on GenesisL1: 3D structure, binding sites…

PDB: 3NH6
Type: protein
Length: 274 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATP-binding cassette sub-family B member 6, mitochondrial
UniProt: Q9NP58
Pockets: 4 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ATP-binding cassette sub-family B member 6, mitochondrial	protein	274	39% helix, 24% strand	Q9NP58

Ligands and binding sites

BME · Beta-mercaptoethanol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	211	0.53	0.77	24	BME
2	101	0.47	0.80	17	BME
3	88	0.41	0.78	16	empty
4	74	0.37	0.77	19	empty

Compared structures

3NH6 · Nucleotide Binding Domain of human ABCB6 (apo structure) · the same entry in another collection · chain A against A, TM-score 1.00
Q9NP58 · AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family B member 6… · a predicted model of the same protein · chain A against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NP58
Elsewhere: RCSB PDB 3NH6 · PDBe 3NH6 · UniProt Q9NP58

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