MolNFT v1 · #177507 · protein

Mitochondrial outer membrane protein

7EKL · ATP-binding cassette sub-family B member 6: “Mitochondrial outer membrane protein”. Electron microscopy, 2 ligands (ATP, MG), 19 pockets (best druggability 0.86). MolNFT v1 #177507 on GenesisL1: 3D structure, binding sites and…

PDB: 7EKL
Type: protein
Length: 1,180 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATP-binding cassette sub-family B member 6
EC: 7.6.2.5
UniProt: Q9NP58
Ligands: ATP, MG
Pockets: 19 · best druggability 0.86

Structure

electron microscopy · 1 distinct chain · 50% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	ATP-binding cassette sub-family B member 6 (EC 7.6.2.5)	protein	590	50% helix, 9% strand	Q9NP58

Ligands and binding sites

ATP · Adenosine-5'-triphosphate · ligand · 2 copies · chains A, B
MG · Magnesium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

19 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	591	0.86	0.91	54	empty
2	1151	0.86	0.87	118	ATP
3	150	0.80	0.96	26	empty
4	349	0.80	0.90	37	empty
5	149	0.79	0.96	33	empty

Interfaces

1 interface between chains.

A–B · 8285 Å² buried · 80 hydrogen bonds · protein-protein

Compared structures

7EKL · Mitochondrial outer membrane protein · the same entry in another collection · chain A against A, TM-score 1.00
Q9NP58 · AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family B member 6… · a predicted model of the same protein · chain B against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NP58
Elsewhere: RCSB PDB 7EKL · PDBe 7EKL · UniProt Q9NP58

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.