MolNFT v1 · #72732 · protein
Nucleotide binding domain of human ABCB6 (ADP mg bound structure)
3NHA · ATP-binding cassette sub-family B member 6, mitochondrial: “Nucleotide binding domain of human ABCB6 (ADP mg bound structure)”. X-ray diffraction, 3 ligands (ADP, MG, PO4), 3 pockets (best druggability 0.50). MolNFT v1 #72732 on…
- PDB
- 3NHA
- Type
- protein
- Length
- 278 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-binding cassette sub-family B member 6, mitochondrial
- UniProt
- Q9NP58
- Ligands
- ADP, MG, PO4
- Pockets
- 3 · best druggability 0.50
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP-binding cassette sub-family B member 6, mitochondrial | protein | 278 | 38% helix, 22% strand | Q9NP58 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
- PO4 · Phosphate ion · ion · chains A
- BME · Beta-mercaptoethanol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 192 | 0.50 | 0.76 | 25 | BME |
| 2 | 103 | 0.46 | 0.80 | 15 | PO4 |
| 3 | 77 | 0.37 | 0.77 | 15 | empty |
Compared structures
- 3NHA · Nucleotide Binding Domain of Human ABCB6 (ADP Mg bound structure) · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NP58 · AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family B member 6… · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NP58
- Elsewhere: RCSB PDB 3NHA · PDBe 3NHA · UniProt Q9NP58
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