UniProt Q9H490
Phosphatidylinositol glycan anchor biosynthesis class U protein (Q9H490)
Phosphatidylinositol glycan anchor biosynthesis class U protein (UniProt Q9H490): 6 experimental structures and 1 predicted model on GenesisL1, 13 ligands bound, 40 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9H490
- Protein
- Phosphatidylinositol glycan anchor biosynthesis class U protein
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 13
- Pockets
- 40 · 5 records with a druggable one
Structures
7 records of Q9H490 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7W72 | Structure of a human glycosylphosphatidylinositol (GPI) transamidase | electron microscopy | U | 8JY | 6 (best 0.86) |
| 7W72 | Structure of a human glycosylphosphatidylinositol (gpi) transamidase | electron microscopy | U | 8JY | — |
| 7WLD | Cryo-EM structure of the human glycosylphosphatidylinositol transamidase complex at 2.53 Angstrom… | electron microscopy | U | BJR, Y01, P5S, CLR, PA1, CDL | 8 (best 0.87) |
| 7WLD | Cryo-EM structure of the human glycosylphosphatidylinositol transamidase complex at 2.53 ångström… | electron microscopy | U | BJR, Y01, P5S, CLR, CDL, DKB | — |
| 8IMX | Cryo-EM structure of GPI-T with a chimeric GPI-anchored protein | electron microscopy | U | Y01, 6OU, LBN, 80T, PA1, 81Q | 10 (best 0.80) |
| 8IMY | Cryo-EM structure of GPI-T (inactive mutant) with GPI and proULBP2, a proprotein substrate | electron microscopy | U | 6OU, Y01, LBN, 81Q, PA1, 80T | 9 (best 0.81) |
| Q9H490 | AlphaFold monomer V2.0 prediction for phosphatidylinositol glycan anchor biosynthesis class U… | predicted | A | — | 7 (best 0.70) |
Ligands
- Y01 · Cholesterol hemisuccinate · in 4 records
- PA1 · 2-amino-2-deoxy-alpha-D-glucopyranose · in 3 records
- 06O · [(2~{R})-1-hexadecanoyloxy-3-[[(1~{S},2~{R},3~{R}, 4~{S},5~{S},6~{R})-2-hexadecanoyloxy-3,4,5,6-tetrakis(oxidanyl)cyclohexyl]oxy-oxidanyl-phosphoryl]oxy-propan-2-yl] (9~{Z},11~{Z})-octadeca-9, 11-dienoate · in 2 records
- 6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · in 2 records
- 80T · [(2R)-1-hexadecanoyloxy-3-[[3-[[(2R)-3-hexadecanoyloxy-2-[(Z)-octadec-9-enoyl]oxy-propoxy]-oxidanyl-phosphoryl]oxy-2-oxidanyl-propoxy]-oxidanyl-phosphoryl]oxy-propan-2-yl] (Z)-octadec-9-enoate · in 2 records
- 81Q · [(2R)-1-[[(1S,2R,3R,4S,5S,6R)-2-hexadecanoyloxy-3,4,5,6-tetrakis(oxidanyl)cyclohexyl]oxy-oxidanyl-phosphoryl]oxy-3-octadecoxy-propan-2-yl] (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate · in 2 records
- 8JY · [2-[[(2~{R})-2-hexanoyloxy-3-[(~{E})-hex-3-enoxy]propoxy]-oxidanyl-phosphoryl]oxy-3,4,5,6-tetrakis(oxidanyl)phenyl] (2~{E},4~{E})-hepta-2,4-dienoate · in 2 records
- BJR · (4S,7R)-7-[(hexadecanoyloxy)methyl]-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-3,5,8-trioxa-4lambda~5~-phosphahexacosan-1-aminium · in 2 records
- CDL · Cardiolipin · in 2 records
- CLR · Cholesterol · in 2 records
- DKB · [(2R)-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] octadecanoate · in 2 records
- LBN · 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine · in 2 records
- P5S · O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy) propyl]oxy}(hydroxy)phosphoryl]-L-serine · in 2 records
Experiment against prediction
- 8IMX chain U against the predicted model Q9H490: TM-score 0.99, RMSD 0.60 Å
- 8IMY chain U against the predicted model Q9H490: TM-score 0.99, RMSD 0.61 Å
- 7W72 chain U against the predicted model Q9H490: TM-score 0.99, RMSD 0.69 Å
- 7W72 chain U against the predicted model Q9H490: TM-score 0.99, RMSD 0.69 Å
- 7WLD chain U against the predicted model Q9H490: TM-score 0.98, RMSD 0.99 Å
- 7WLD chain U against the predicted model Q9H490: TM-score 0.98, RMSD 0.99 Å
- 8IMX chain U against the predicted model Q9U6Y3: TM-score 0.20, RMSD 6.50 Å
- 8IMY chain U against the predicted model Q9U6Y3: TM-score 0.19, RMSD 6.47 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.