UniProt Q99PJ1
Protocadherin-15 (Q99PJ1)
Protocadherin-15 (UniProt Q99PJ1): 33 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 44 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q99PJ1
- Protein
- Protocadherin-15
- Experimental structures
- 33
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 44 · 7 records with a druggable one
Structures
34 records of Q99PJ1 in the MolNFT archive: 33 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4APX | Crystal structure of mouse cadherin-23 EC1-2 and protocadherin-15 EC1- 2 form I | x-ray diffraction | B | — | — |
| 4APX | Crystal structure of mouse cadherin-23 EC1-2 and protocadherin-15 EC1-2 form I | x-ray diffraction | B | — | — |
| 4AQ8 | Crystal structure of mouse cadherin-23 EC1-2 and protocadherin-15 EC1- 2 form II | x-ray diffraction | C, D | — | — |
| 4AQ8 | Crystal structure of mouse cadherin-23 EC1-2 and protocadherin-15 EC1-2 form II | x-ray diffraction | C, D | — | — |
| 4AQA | Crystal structure of deafness associated mutant mouse cadherin-23 EC1- 2D124G and protocadherin-15… | x-ray diffraction | B | — | — |
| 4AQA | Crystal structure of deafness associated mutant mouse cadherin-23 EC1-2D124G and protocadherin-15… | x-ray diffraction | B | — | — |
| 4AQE | Crystal structure of deafness associated mutant mouse cadherin-23 EC1- 2S70P and protocadherin-15… | x-ray diffraction | B | — | — |
| 4AQE | Crystal structure of deafness associated mutant mouse cadherin-23 EC1-2S70P and protocadherin-15… | x-ray diffraction | B | — | — |
| 4XXW | Crystal structure of mouse Cadherin-23 EC1-2 and Protocadherin-15 EC1-2 splice variant | x-ray diffraction | B, A | CA, CL | 8 (best 0.71) |
| 4XXW | Crystal structure of mouse cadherin-23 EC1-2 and protocadherin-15 EC1- 2 splice variant | x-ray diffraction | B, A | — | — |
| 5KJ4 | Crystal Structure of Mouse Protocadherin-15 EC9-10 | x-ray diffraction | A, B, C, D | CA | 6 (best 0.62) |
| 5KJ4 | Crystal structure of mouse protocadherin-15 EC9-10 | x-ray diffraction | A, B, C, D | CA | — |
| 5TPK | Crystal Structure of Mouse Protocadherin-15 EC7-8 V875A | x-ray diffraction | A | CA | — |
| 5TPK | Crystal structure of mouse protocadherin-15 EC7-8 V875A | x-ray diffraction | A | CA | — |
| 5W1D | Crystal Structure of Mouse Protocadherin-15 EC4-7 | x-ray diffraction | A | CA, K | — |
| 5W1D | Crystal structure of mouse protocadherin-15 EC4-7 | x-ray diffraction | A | CA, K | — |
| 6BWN | Crystal Structure of Mouse Protocadherin-15 EC6-7 | x-ray diffraction | A | CA, K | — |
| 6BWN | Crystal structure of mouse protocadherin-15 EC6-7 | x-ray diffraction | A | CA, K | — |
| 6BXU | Crystal Structure of Mouse Protocadherin-15 EC5-7 I582T | x-ray diffraction | A, B | CA | 4 (best 0.60) |
| 6BXU | Crystal structure of mouse protocadherin-15 EC5-7 I582T | x-ray diffraction | A, B | CA | — |
| 6C10 | Crystal structure of mouse PCDH15 EC11-EL | x-ray diffraction | A | MAN | 2 (best 0.52) |
| 6C10 | Crystal structure of mouse PCDH15 EC11-el | x-ray diffraction | A | MAN | — |
| 6C13 | CryoEM structure of mouse PCDH15-4EC-LHFPL5 complex | electron microscopy | A, B | NAG, BMA, MAN | 10 (best 0.80) |
| 6C13 | Cryoem structure of mouse PCDH15-4EC-LHFPL5 complex | electron microscopy | A, B | NAG, BMA, MAN | — |
| 6C14 | CryoEM structure of mouse PCDH15-1EC-LHFPL5 complex | electron microscopy | A, C | — | 10 (best 0.80) |
| 6C14 | Cryoem structure of mouse PCDH15-1EC-LHFPL5 complex | electron microscopy | A, C | — | — |
| 6CV7 | Mouse Protocadherin-15 Extracellular Cadherin Domains 1 through 3 | x-ray diffraction | A | CA, MAN, NAG | — |
| 6CV7 | Mouse protocadherin-15 extracellular cadherin domains 1 through 3 | x-ray diffraction | A | CA, MAN, NAG | — |
| 6EET | Crystal structure of mouse Protocadherin-15 EC9-MAD12 | x-ray diffraction | A | NAG, MAN, CA | — |
| 6EET | Crystal structure of mouse protocadherin-15 EC9-MAD12 | x-ray diffraction | A | NAG, MAN, CA | — |
| 6N22 | Crystal structure of mouse Protocadherin-15 EC1-2 BAP | x-ray diffraction | A | CA | — |
| 6N22 | Crystal structure of mouse protocadherin-15 EC1-2 bap | x-ray diffraction | A | CA | — |
| 8UMZ | Crystal Structure of Engineered Mouse Protocadherin-15 EC4-EC7 Connection | x-ray diffraction | A, B | CA, NA | 1 (best 0.54) |
| Q99PJ1 | AlphaFold monomer V2.0 prediction for protocadherin-15 (Q99PJ1) | predicted | A | — | 3 (best 0.49) |
Ligands
Experiment against prediction
- 6EET chain A against the predicted model Q99PJ1: TM-score 0.93, RMSD 2.25 Å
- 6EET chain A against the predicted model Q99PJ1: TM-score 0.93, RMSD 2.25 Å
- 6C10 chain A against the predicted model Q99PJ1: TM-score 0.86, RMSD 2.16 Å
- 6C10 chain A against the predicted model Q99PJ1: TM-score 0.86, RMSD 2.16 Å
- 5TPK chain A against the predicted model Q99PJ1: TM-score 0.83, RMSD 2.61 Å
- 5TPK chain A against the predicted model Q99PJ1: TM-score 0.83, RMSD 2.61 Å
- 6N22 chain A against the predicted model Q99PJ1: TM-score 0.82, RMSD 2.78 Å
- 6N22 chain A against the predicted model Q99PJ1: TM-score 0.82, RMSD 2.78 Å
- 4XXW chain B against the predicted model Q99PJ1: TM-score 0.82, RMSD 2.79 Å
- 4XXW chain B against the predicted model Q99PJ1: TM-score 0.82, RMSD 2.79 Å
Elsewhere
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