UniProt Q98GN8
Cyclic nucleotide-gated potassium channel mll3241 (Q98GN8)
Cyclic nucleotide-gated potassium channel mll3241 (UniProt Q98GN8): 46 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 160 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q98GN8
- Protein
- Cyclic nucleotide-gated potassium channel mll3241
- Experimental structures
- 46
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 160 · 8 records with a druggable one
Structures
47 records of Q98GN8 in the MolNFT archive: 46 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1U12 | M. loti cyclic nucleotide binding domain mutant | x-ray diffraction | A, B | — | — |
| 1U12 | M. loti cyclic nucleotide binding domain mutant | x-ray diffraction | A, B | — | — |
| 1VP6 | M.loti ion channel cylic nucleotide binding domain | x-ray diffraction | A, C | — | — |
| 1VP6 | M.LOTI ion channel cylic nucleotide binding domain | x-ray diffraction | A, C | — | — |
| 2K0G | Solution Structure of a Bacterial Cyclic Nucleotide-Activated K+ Channel Binding Domain in Complex… | solution nmr | A | — | — |
| 2K0G | Solution structure of a bacterial cyclic nucleotide-activated K+ channel binding domain in complex… | solution nmr | A | — | — |
| 2KXL | Solution structure of a bacterial cyclic nucleotide-activated K+ channel binding domain in the… | solution nmr | A | — | — |
| 2KXL | Solution structure of a bacterial cyclic nucleotide-activated K+ channel binding domain in the… | solution nmr | A | — | — |
| 2ZD9 | Structure of a Bacterial Cyclic-Nucleotide Regulated Ion Channel | x-ray diffraction | A, B, C, D | — | — |
| 2ZD9 | Structure of a bacterial cyclic-nucleotide regulated ion channel | x-ray diffraction | A, B, C, D | — | — |
| 3BEH | Structure of a Bacterial Cyclic Nucleotide Regulated Ion Channel | x-ray diffraction | A, B, C, D | — | — |
| 3BEH | Structure of a bacterial cyclic nucleotide regulated ion channel | x-ray diffraction | A, B, C, D | — | — |
| 3CL1 | M. loti cyclic-nucleotide binding domain, cyclic-GMP bound | x-ray diffraction | A, B | — | — |
| 3CL1 | M. loti cyclic-nucleotide binding domain, cyclic-gmp bound | x-ray diffraction | A, B | — | — |
| 3CLP | M. loti cyclic-nucleotide binding domain mutant 2 | x-ray diffraction | A, C | — | — |
| 3CLP | M. loti cyclic-nucleotide binding domain mutant 2 | x-ray diffraction | A, C | — | — |
| 3CO2 | Mlotik1 ion channel cyclic-nucleotide binding domain mutant | x-ray diffraction | A, B, C, D | — | — |
| 3CO2 | MLOTIK1 ion channel cyclic-nucleotide binding domain mutant | x-ray diffraction | A, B, C, D | — | — |
| 4CHV | The electron crystallography structure of the cAMP-bound potassium channel MloK1 | electron crystallography | A, B, C, D | — | — |
| 4CHV | The electron crystallography structure of the camp-bound potassium channel MLOK1 | electron crystallography | A, B, C, D | — | — |
| 4CHW | The electron crystallography structure of the cAMP-free potassium channel MloK1 | electron crystallography | A, B, C, D | — | — |
| 4CHW | The electron crystallography structure of the camp-free potassium channel MLOK1 | electron crystallography | A, B, C, D | — | — |
| 4MUV | M. loti cyclic-nucleotide binding domain mutant displaying inverted ligand selectivity, cyclic-GMP… | x-ray diffraction | A, B | — | — |
| 4MUV | M. loti cyclic-nucleotide binding domain mutant displaying inverted ligand selectivity, cyclic-gmp… | x-ray diffraction | A, B | — | — |
| 6EO1 | The electron crystallography structure of the cAMP-bound potassium channel MloK1 (PCO-refined) | electron crystallography | A, B, C, D | K | 20 (best 0.87) |
| 6EO1 | The electron crystallography structure of the camp-bound potassium channel MLOK1 (pco-refined) | electron crystallography | A, B, C, D | K | — |
| 6I9D | MloK1 consensus structure from single particle analysis of 2D crystals | electron microscopy | A, B, C, D | K | 20 (best 0.87) |
| 6I9D | MLOK1 consensus structure from single particle analysis of 2D crystals | electron microscopy | A, B, C, D | K | — |
| 6IAX | MloK1 model from single particle analysis of 2D crystals, class 1 (extended conformation) | electron microscopy | A, B, C, D | K | — |
| 6IAX | MLOK1 model from single particle analysis of 2D crystals, class 1 (extended conformation) | electron microscopy | A, B, C, D | K | — |
| 6M63 | Crystal structure of a cAMP sensor G-Flamp1. | x-ray diffraction | A, B | CMP | — |
| 6M63 | Crystal structure of a camp sensor G-FLAMP1. | x-ray diffraction | A, B | CRO, CMP | — |
| 6QCY | MloK1 model from single particle analysis of 2D crystals, class 2 (intermediate conformation) | electron microscopy | A, B, C, D | K | 20 (best 0.86) |
| 6QCY | MLOK1 model from single particle analysis of 2D crystals, class 2 (intermediate conformation) | electron microscopy | A, B, C, D | K | — |
| 6QCZ | MloK1 model from single particle analysis of 2D crystals, class 3 (intermediate extended… | electron microscopy | A, B, C, D | K | 20 (best 0.85) |
| 6QCZ | MLOK1 model from single particle analysis of 2D crystals, class 3 (intermediate extended… | electron microscopy | A, B, C, D | K | — |
| 6QD0 | MloK1 model from single particle analysis of 2D crystals, class 4 (compact/open conformation) | electron microscopy | A, B, C, D | K | 20 (best 0.87) |
| 6QD0 | MLOK1 model from single particle analysis of 2D crystals, class 4 (COMPACT/OPEN conformation) | electron microscopy | A, B, C, D | K | — |
| 6QD1 | MloK1 model from single particle analysis of 2D crystals, class 5 (intermediate compact… | electron microscopy | A, B, C, D | K | 20 (best 0.88) |
| 6QD1 | MLOK1 model from single particle analysis of 2D crystals, class 5 (intermediate compact… | electron microscopy | A, B, C, D | K | — |
| 6QD2 | MloK1 model from single particle analysis of 2D crystals, class 6 (intermediate compact… | electron microscopy | A, B, C, D | K | 20 (best 0.82) |
| 6QD2 | MLOK1 model from single particle analysis of 2D crystals, class 6 (intermediate compact… | electron microscopy | A, B, C, D | K | — |
| 6QD3 | MloK1 model from single particle analysis of 2D crystals, class 7 (intermediate conformation) | electron microscopy | A, B, C, D | K | 20 (best 0.87) |
| 6QD3 | MLOK1 model from single particle analysis of 2D crystals, class 7 (intermediate conformation) | electron microscopy | A, B, C, D | K | — |
| 6QD4 | MloK1 model from single particle analysis of 2D crystals, class 8 (intermediate conformation) | electron microscopy | A, B, C, D | K | — |
| 6QD4 | MLOK1 model from single particle analysis of 2D crystals, class 8 (intermediate conformation) | electron microscopy | A, B, C, D | K | — |
| Q98GN8 | AlphaFold monomer V2.0 prediction for cyclic nucleotide-gated potassium channel MLL3241 (Q98GN8) | predicted | A | — | — |
Ligands
Experiment against prediction
- 3CL1 chain B against the predicted model Q98GN8: TM-score 0.98, RMSD 0.57 Å
- 3CL1 chain B against the predicted model Q98GN8: TM-score 0.98, RMSD 0.57 Å
- 3CL1 chain A against the predicted model Q98GN8: TM-score 0.98, RMSD 0.59 Å
- 3CL1 chain A against the predicted model Q98GN8: TM-score 0.98, RMSD 0.59 Å
- 3CLP chain A against the predicted model Q98GN8: TM-score 0.98, RMSD 0.76 Å
- 3CLP chain A against the predicted model Q98GN8: TM-score 0.98, RMSD 0.76 Å
- 3CLP chain C against the predicted model Q98GN8: TM-score 0.98, RMSD 0.78 Å
- 3CLP chain C against the predicted model Q98GN8: TM-score 0.98, RMSD 0.78 Å
- 1VP6 chain C against the predicted model Q98GN8: TM-score 0.97, RMSD 0.79 Å
- 1VP6 chain C against the predicted model Q98GN8: TM-score 0.97, RMSD 0.79 Å
Elsewhere
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