MolNFT v1 · #60317 · protein
MLOTIK1 ion channel cyclic-nucleotide binding domain mutant
3CO2 · MLOTIK1 ion channel protein: “MLOTIK1 ion channel cyclic-nucleotide binding domain mutant”. X-ray diffraction, 7 pockets (best druggability 0.66). MolNFT v1 #60317 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3CO2
- Type
- protein
- Length
- 502 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MLOTIK1 ion channel protein
- UniProt
- Q98GN8
- Pockets
- 7 · best druggability 0.66
Structure
x-ray diffraction · 4 distinct chains · 33% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MLOTIK1 ion channel protein | protein | 126 | 34% helix, 25% strand | Q98GN8 |
| B | MLOTIK1 ion channel protein | protein | 128 | 34% helix, 28% strand | Q98GN8 |
| C | MLOTIK1 ion channel protein | protein | 119 | 29% helix, 29% strand | Q98GN8 |
| D | MLOTIK1 ion channel protein | protein | 129 | 34% helix, 29% strand | Q98GN8 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 639 | 0.66 | 0.75 | 52 | empty |
| 2 | 179 | 0.56 | 0.80 | 22 | empty |
| 3 | 128 | 0.53 | 0.81 | 20 | empty |
| 4 | 84 | 0.44 | 0.80 | 17 | empty |
| 5 | 85 | 0.41 | 0.78 | 18 | empty |
Interfaces
5 interfaces between chains.
- B–C · 854 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 745 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 376 Ų buried · 0 hydrogen bonds · protein-protein
- C–D · 356 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 97 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 3CO2 · Mlotik1 ion channel cyclic-nucleotide binding domain mutant · the same entry in another collection · chain D against D, TM-score 1.00
- Q98GN8 · AlphaFold monomer V2.0 prediction for cyclic nucleotide-gated potassium channel MLL3241… · a predicted model of the same protein · chain C against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q98GN8
- Elsewhere: RCSB PDB 3CO2 · PDBe 3CO2 · UniProt Q98GN8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.