MolNFT v1 · #156495 · protein

Crystal structure of a camp sensor G-FLAMP1.

6M63 · Chimera of cyclic nucleotide-gated potassium channel…: “Crystal structure of a camp sensor G-FLAMP1.”. X-ray diffraction, 2 ligands (CRO, CMP), 7 pockets (best druggability 0.77). MolNFT v1 #156495 on GenesisL1: 3D structure…

PDB: 6M63
Type: protein
Length: 717 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chimera of cyclic nucleotide-gated potassium channel MLL3241 and yellow fluorescent…
UniProt: Q98GN8, A0A059PIR9
Ligands: CRO, CMP
Pockets: 7 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 23% helix, 43% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Chimera of cyclic nucleotide-gated potassium channel MLL3241 and yellow fluorescent protein	protein	359	23% helix, 43% strand	Q98GN8, A0A059PIR9
B	Chimera of cyclic nucleotide-gated potassium channel MLL3241 and yellow fluorescent protein	protein	358	22% helix, 43% strand	Q98GN8, A0A059PIR9

Ligands and binding sites

CRO · {2-[(1R,2R)-1-amino-2-hydroxypropyl]-4-(4-hydroxybenzylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid · ligand · 2 copies · chains A, B
CMP · Adenosine-3',5'-cyclic-monophosphate · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	93	0.77	0.97	28	CRO
2	87	0.76	0.98	24	CRO
3	741	0.75	0.80	64	empty
4	406	0.70	0.81	49	CMP
5	263	0.70	0.85	38	CMP

Interfaces

1 interface between chains.

A–B · 512 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 cofactor (chromophore).

Compared structures

6M63 · Crystal structure of a cAMP sensor G-Flamp1. · the same entry in another collection · chain A against A, TM-score 1.00
Q98GN8 · AlphaFold monomer V2.0 prediction for cyclic nucleotide-gated potassium channel MLL3241… · a predicted model of the same protein · chain B against A, TM-score 0.36

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q98GN8
Every structure of UniProt A0A059PIR9
Elsewhere: RCSB PDB 6M63 · PDBe 6M63 · UniProt Q98GN8 · UniProt A0A059PIR9

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