MolNFT v1 · #147795 · protein
The electron crystallography structure of the camp-bound potassium channel MLOK1 (pco-refined)
6EO1 · Cyclic nucleotide-gated potassium channel MLL3241: “The electron crystallography structure of the camp-bound potassium channel MLOK1 (pco-refined)”. Electron crystallography, 1 ligand (K), 20 pockets (best druggability 0.87). MolNFT…
- PDB
- 6EO1
- Type
- protein
- Length
- 1,420 residues
- Chains
- 4
- Method
- electron crystallography
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cyclic nucleotide-gated potassium channel MLL3241
- UniProt
- Q98GN8
- Ligands
- K
- Pockets
- 20 · best druggability 0.87
Structure
electron crystallography · 1 distinct chain · 59% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Cyclic nucleotide-gated potassium channel MLL3241 | protein | 355 | 59% helix, 4% strand | Q98GN8 |
Ligands and binding sites
- K · Potassium ion · metal · 2 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1145 | 0.87 | 0.88 | 126 | empty |
| 2 | 550 | 0.75 | 0.82 | 61 | empty |
| 3 | 563 | 0.74 | 0.81 | 60 | empty |
| 4 | 246 | 0.71 | 0.86 | 45 | empty |
| 5 | 222 | 0.70 | 0.86 | 27 | empty |
Interfaces
6 interfaces between chains.
- A–D · 1867 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 1861 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 1858 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 1857 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 52 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6EO1 · The electron crystallography structure of the cAMP-bound potassium channel MloK1… · the same entry in another collection · chain D against D, TM-score 1.00
- Q98GN8 · AlphaFold monomer V2.0 prediction for cyclic nucleotide-gated potassium channel MLL3241… · a predicted model of the same protein · chain B against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q98GN8
- Elsewhere: RCSB PDB 6EO1 · PDBe 6EO1 · UniProt Q98GN8
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