MolNFT v1 · #60234 · protein
M. loti cyclic-nucleotide binding domain mutant 2
3CLP · MLL3241 protein: “M. loti cyclic-nucleotide binding domain mutant 2”. X-ray diffraction, 1 ligand (CMP), 3 pockets (best druggability 0.55). MolNFT v1 #60234 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3CLP
- Type
- protein
- Length
- 265 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MLL3241 protein
- UniProt
- Q98GN8
- Ligands
- CMP
- Pockets
- 3 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MLL3241 protein | protein | 132 | 42% helix, 25% strand | Q98GN8 |
| C | MLL3241 protein | protein | 133 | 43% helix, 25% strand | Q98GN8 |
Ligands and binding sites
- CMP · Adenosine-3',5'-cyclic-monophosphate · ligand · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 96 | 0.55 | 0.85 | 17 | CMP |
| 2 | 88 | 0.55 | 0.85 | 18 | CMP |
| 3 | 76 | 0.37 | 0.77 | 18 | empty |
Interfaces
1 interface between chains.
- A–C · 506 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 3CLP · M. loti cyclic-nucleotide binding domain mutant 2 · the same entry in another collection · chain A against A, TM-score 1.00
- Q98GN8 · AlphaFold monomer V2.0 prediction for cyclic nucleotide-gated potassium channel MLL3241… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q98GN8
- Elsewhere: RCSB PDB 3CLP · PDBe 3CLP · UniProt Q98GN8
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