MolNFT v1 · #152219 · protein
MLOK1 model from single particle analysis of 2D crystals, class 1 (extended conformation)
6IAX · Cyclic nucleotide-gated potassium channel MLL3241: “MLOK1 model from single particle analysis of 2D crystals, class 1 (extended conformation)”. Electron microscopy, 1 ligand (K), 20 pockets (best druggability 0.85). MolNFT v1…
- PDB
- 6IAX
- Type
- protein
- Length
- 1,420 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cyclic nucleotide-gated potassium channel MLL3241
- UniProt
- Q98GN8
- Ligands
- K
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 56% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Cyclic nucleotide-gated potassium channel MLL3241 | protein | 355 | 56% helix, 8% strand | Q98GN8 |
Ligands and binding sites
- K · Potassium ion · metal · 2 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 679 | 0.85 | 0.89 | 63 | empty |
| 2 | 1028 | 0.74 | 0.77 | 111 | empty |
| 3 | 179 | 0.73 | 0.90 | 36 | empty |
| 4 | 934 | 0.73 | 0.77 | 105 | empty |
| 5 | 846 | 0.73 | 0.77 | 85 | empty |
Interfaces
6 interfaces between chains.
- A–B · 2221 Ų buried · 15 hydrogen bonds · protein-protein
- A–D · 2216 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 2213 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 2210 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 60 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6IAX · MloK1 model from single particle analysis of 2D crystals, class 1 (extended conformation) · the same entry in another collection · chain D against D, TM-score 1.00
- Q98GN8 · AlphaFold monomer V2.0 prediction for cyclic nucleotide-gated potassium channel MLL3241… · a predicted model of the same protein · chain A against A, TM-score 0.75
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q98GN8
- Elsewhere: RCSB PDB 6IAX · PDBe 6IAX · UniProt Q98GN8
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