MolNFT v1 · #161388 · protein
MLOK1 model from single particle analysis of 2D crystals, class 5 (intermediate compact conformation)
6QD1 · Cyclic nucleotide-gated potassium channel MLL3241: “MLOK1 model from single particle analysis of 2D crystals, class 5 (intermediate compact conformation)”. Electron microscopy, 1 ligand (K), 20 pockets (best druggability 0.88).…
- PDB
- 6QD1
- Type
- protein
- Length
- 1,420 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cyclic nucleotide-gated potassium channel MLL3241
- UniProt
- Q98GN8
- Ligands
- K
- Pockets
- 20 · best druggability 0.88
Structure
electron microscopy · 1 distinct chain · 55% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Cyclic nucleotide-gated potassium channel MLL3241 | protein | 355 | 55% helix, 7% strand | Q98GN8 |
Ligands and binding sites
- K · Potassium ion · metal · 2 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1097 | 0.88 | 0.89 | 133 | empty |
| 2 | 61 | 0.70 | 0.95 | 19 | empty |
| 3 | 53 | 0.69 | 0.96 | 17 | empty |
| 4 | 649 | 0.68 | 0.77 | 70 | empty |
| 5 | 606 | 0.68 | 0.77 | 71 | empty |
Interfaces
6 interfaces between chains.
- A–B · 2319 Ų buried · 16 hydrogen bonds · protein-protein
- B–C · 2313 Ų buried · 16 hydrogen bonds · protein-protein
- A–D · 2310 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 2305 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 62 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6QD1 · MloK1 model from single particle analysis of 2D crystals, class 5 (intermediate compact… · the same entry in another collection · chain D against D, TM-score 1.00
- Q98GN8 · AlphaFold monomer V2.0 prediction for cyclic nucleotide-gated potassium channel MLL3241… · a predicted model of the same protein · chain D against A, TM-score 0.74
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q98GN8
- Elsewhere: RCSB PDB 6QD1 · PDBe 6QD1 · UniProt Q98GN8
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