UniProt Q96RD7
Pannexin-1 (Q96RD7)
Pannexin-1 (UniProt Q96RD7): 41 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 444 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q96RD7
- Protein
- Pannexin-1
- Experimental structures
- 41
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 444 · 23 records with a druggable one
Structures
42 records of Q96RD7 in the MolNFT archive: 41 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6LTN | cryo-EM structure of C-terminal truncated human Pannexin1 | electron microscopy | E, A, B, C, D, F, G | — | 20 (best 0.77) |
| 6LTN | Cryo-EM structure of C-terminal truncated human PANNEXIN1 | electron microscopy | E, A, B, C, D, F, G | — | — |
| 6LTO | cryo-EM structure of full length human Pannexin1 | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.81) |
| 6LTO | Cryo-EM structure of full length human PANNEXIN1 | electron microscopy | A, B, C, D, E, F, G | — | — |
| 6M02 | cryo-EM structure of human Pannexin 1 channel | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.77) |
| 6M02 | Cryo-EM structure of human pannexin 1 channel | electron microscopy | A, B, C, D, E, F, G | — | — |
| 6M66 | The Cryo-EM Structure of Human Pannexin 1 | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.84) |
| 6M66 | The cryo-EM structure of human pannexin 1 | electron microscopy | A, B, C, D, E, F, G | — | — |
| 6M67 | The Cryo-EM Structure of Human Pannexin 1 with D376E/D379E Mutation | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.83) |
| 6M67 | The cryo-EM structure of human pannexin 1 with D376E/D379E mutation | electron microscopy | A, B, C, D, E, F, G | — | — |
| 6M68 | The Cryo-EM Structure of Human Pannexin 1 in the Presence of CBX | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.85) |
| 6M68 | The cryo-EM structure of human pannexin 1 in the presence of cbx | electron microscopy | A, B, C, D, E, F, G | — | — |
| 6V6D | Cryo-EM structure of human pannexin 1 | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.65) |
| 6V6D | Cryo-EM structure of human pannexin 1 | electron microscopy | A, B, C, D, E, F, G | — | — |
| 6WBF | Cryo-EM structure of wild type human Pannexin 1 channel | electron microscopy | A, B, C, D, E, F, G | PTY, 3PE, DGA, CLR, NAG | 20 (best 0.80) |
| 6WBF | Cryo-EM structure of wild type human pannexin 1 channel | electron microscopy | A, B, C, D, E, F, G | PTY, 3PE, DGA, CLR, NAG | — |
| 6WBG | Cryo-EM structure of human Pannexin 1 channel with its C-terminal tail cleaved by caspase-7 | electron microscopy | A, B, C, D, E, F, G | PTY, 3PE, DGA, CLR, NAG | 20 (best 0.78) |
| 6WBG | Cryo-EM structure of human pannexin 1 channel with its C-terminal tail cleaved by caspase-7 | electron microscopy | A, B, C, D, E, F, G | PTY, 3PE, DGA, CLR, NAG | — |
| 6WBI | Cryo-EM structure of human Pannexin 1 channel with its C-terminal tail cleaved by caspase-7, in… | electron microscopy | A, B, C, D, E, F, G | CBO | 20 (best 0.85) |
| 6WBI | Cryo-EM structure of human pannexin 1 channel with its C-terminal tail cleaved by caspase-7, in… | electron microscopy | A, B, C, D, E, F, G | CBO | — |
| 6WBK | Cryo-EM structure of human Pannexin 1 channel with deletion of N-terminal helix and C-terminal tail | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.81) |
| 6WBK | Cryo-EM structure of human pannexin 1 channel with deletion of N- terminal helix and C-terminal tail | electron microscopy | A, B, C, D, E, F, G | — | — |
| 6WBL | Cryo-EM structure of human Pannexin 1 channel with deletion of N-terminal helix and C-terminal… | electron microscopy | A, B, C, D, E, F, G | CBO | 20 (best 0.86) |
| 6WBL | Cryo-EM structure of human pannexin 1 channel with deletion of N- terminal helix and C-terminal… | electron microscopy | A, B, C, D, E, F, G | — | — |
| 6WBM | Cryo-EM structure of human Pannexin 1 channel N255A mutant | electron microscopy | A, B, C, D, E, F, G | PTY, 3PE, DGA, CLR | 20 (best 0.85) |
| 6WBM | Cryo-EM structure of human pannexin 1 channel N255A mutant | electron microscopy | A, B, C, D, E, F, G | PTY, 3PE, DGA, CLR | — |
| 6WBN | Cryo-EM structure of human Pannexin 1 channel N255A mutant, gap junction | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N | PTY, 3PE, DGA, CLR | 20 (best 0.83) |
| 6WBN | Cryo-EM structure of human pannexin 1 channel N255A mutant, gap junction | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N | PTY, 3PE, DGA, CLR | — |
| 7DWB | Human Pannexin1 model | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.90) |
| 7DWB | Human PANNEXIN1 model | electron microscopy | A, B, C, D, E, F, G | — | — |
| 7F8J | Cryo-EM structure of human pannexin-1 in a nanodisc | electron microscopy | A, B, C, D, E, F, G | LBN | 20 (best 0.86) |
| 7F8J | Cryo-EM structure of human pannexin-1 in a nanodisc | electron microscopy | A, B, C, D, E, F, G | LBN | — |
| 7F8N | Human pannexin-1 showing a conformational change in the N-terminal domain and blocked pore | electron microscopy | A, B, C, D, E, F, G | LBN | 20 (best 0.74) |
| 7F8N | Human pannexin-1 showing a conformational change in the N-terminal domain and blocked pore | electron microscopy | A, B, C, D, E, F, G | LBN | — |
| 7F8O | Cryo-EM structure of the C-terminal deletion mutant of human PANX1 in a nanodisc | electron microscopy | A, B, C, D, E, F, G | LBN | 20 (best 0.79) |
| 7F8O | Cryo-EM structure of the C-terminal deletion mutant of human PANX1 in a nanodisc | electron microscopy | A, B, C, D, E, F, G | LBN | — |
| 7WSV | Cryo-EM structure of the N-terminal deletion mutant of human pannexin-1 in a nanodisc | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.76) |
| 7WSV | Cryo-EM structure of the N-terminal deletion mutant of human pannexin- 1 in a nanodisc | electron microscopy | A, B, C, D, E, F, G | — | — |
| 8GTS | CryoEM structure of human Pannexin1 with R217H congenital mutation. | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.75) |
| 8GTT | Cryo-EM structure of human Pannexin1 resembling Pannexin2 pore with W74R/R75Dmutations | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.70) |
| 8GYO | Inner channel lipids regulated gating mechanism of human pannexins. | electron microscopy | A, B, C, D, E, F, G | NAG, AJP, PC1 | 20 (best 0.80) |
| Q96RD7 | AlphaFold monomer V2.0 prediction for pannexin-1 (Q96RD7) | predicted | A | — | 4 (best 0.62) |
Ligands
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 8 records
- CLR · Cholesterol · in 8 records
- DGA · Diacyl glycerol · in 8 records
- PTY · Phosphatidylethanolamine · in 8 records
- LBN · 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine · in 6 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 5 records
- CBO · Carbenoxolone · in 3 records
- AJP · Digitonin · in 1 record
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 1 record
Experiment against prediction
- 6WBM chain G against the predicted model Q96RD7: TM-score 0.98, RMSD 0.93 Å
- 6WBM chain F against the predicted model Q96RD7: TM-score 0.98, RMSD 0.93 Å
- 6WBM chain A against the predicted model Q96RD7: TM-score 0.98, RMSD 0.93 Å
- 6WBM chain D against the predicted model Q96RD7: TM-score 0.98, RMSD 0.93 Å
- 6WBM chain A against the predicted model Q96RD7: TM-score 0.98, RMSD 0.93 Å
- 6WBM chain E against the predicted model Q96RD7: TM-score 0.98, RMSD 0.93 Å
- 6WBM chain B against the predicted model Q96RD7: TM-score 0.98, RMSD 0.93 Å
- 6WBM chain C against the predicted model Q96RD7: TM-score 0.98, RMSD 0.93 Å
- 6WBN chain C against the predicted model Q96RD7: TM-score 0.98, RMSD 0.93 Å
- 6WBN chain J against the predicted model Q96RD7: TM-score 0.98, RMSD 0.93 Å
Elsewhere
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