MolNFT v1 · #166953 · protein
Cryo-EM structure of human pannexin 1
6V6D · Pannexin-1: “Cryo-EM structure of human pannexin 1”. Electron microscopy, 20 pockets (best druggability 0.65). MolNFT v1 #166953 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6V6D
- Type
- protein
- Length
- 1,463 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pannexin-1
- UniProt
- Q96RD7
- Pockets
- 20 · best druggability 0.65
Structure
electron microscopy · 1 distinct chain · 64% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G | Pannexin-1 | protein | 209 | 64% helix, 6% strand | Q96RD7 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 64 | 0.65 | 0.93 | 22 | empty |
| 2 | 402 | 0.61 | 0.77 | 68 | empty |
| 3 | 349 | 0.59 | 0.75 | 32 | empty |
| 4 | 296 | 0.57 | 0.76 | 32 | empty |
| 5 | 313 | 0.57 | 0.77 | 53 | empty |
Interfaces
7 interfaces between chains.
- A–G · 1378 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 1377 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 1373 Ų buried · 9 hydrogen bonds · protein-protein
- D–E · 1371 Ų buried · 10 hydrogen bonds · protein-protein
- F–G · 1370 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 14 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96RD7
- Elsewhere: RCSB PDB 6V6D · PDBe 6V6D · UniProt Q96RD7
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