MolNFT v1 · #176746 · protein
Human PANNEXIN1 model
7DWB · Pannexin-1: “Human PANNEXIN1 model”. Electron microscopy, 20 pockets (best druggability 0.90). MolNFT v1 #176746 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7DWB
- Type
- protein
- Length
- 2,947 residues
- Chains
- 7
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pannexin-1
- UniProt
- Q96RD7
- Pockets
- 20 · best druggability 0.90
Structure
electron microscopy · 1 distinct chain · 46% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G | Pannexin-1 | protein | 421 | 46% helix, 4% strand | Q96RD7 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1044 | 0.90 | 0.91 | 131 | empty |
| 2 | 923 | 0.89 | 0.91 | 105 | empty |
| 3 | 910 | 0.89 | 0.91 | 105 | empty |
| 4 | 819 | 0.88 | 0.91 | 95 | empty |
| 5 | 834 | 0.88 | 0.91 | 95 | empty |
Interfaces
14 interfaces between chains.
- F–G · 4068 Ų buried · 35 hydrogen bonds · protein-protein
- D–E · 4064 Ų buried · 38 hydrogen bonds · protein-protein
- B–C · 4012 Ų buried · 33 hydrogen bonds · protein-protein
- C–D · 4009 Ų buried · 33 hydrogen bonds · protein-protein
- A–B · 4008 Ų buried · 34 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 14 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96RD7
- Elsewhere: RCSB PDB 7DWB · PDBe 7DWB · UniProt Q96RD7
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