UniProt Q96QV1
Hedgehog-interacting protein (Q96QV1)
Hedgehog-interacting protein (UniProt Q96QV1): 22 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 39 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q96QV1
- Protein
- Hedgehog-interacting protein
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 39 · 3 records with a druggable one
Structures
23 records of Q96QV1 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2WFT | Crystal structure of the human HIP ectodomain | x-ray diffraction | A, B | — | — |
| 2WFT | Crystal structure of the human hip ectodomain | x-ray diffraction | A, B | — | — |
| 2WFX | Crystal structure of the complex between human hedgehog-interacting protein HIP and Sonic Hedgehog… | x-ray diffraction | B | — | — |
| 2WFX | Crystal structure of the complex between human hedgehog- interacting protein hip and sonic hedgehog… | x-ray diffraction | B | — | — |
| 2WG3 | Crystal structure of the complex between human hedgehog-interacting protein HIP and desert hedgehog… | x-ray diffraction | C, D | — | — |
| 2WG3 | Crystal structure of the complex between human hedgehog-interacting protein hip and desert hedgehog… | x-ray diffraction | C, D | — | — |
| 2WG4 | Crystal structure of the complex between human hedgehog-interacting protein HIP and sonic hedgehog… | x-ray diffraction | B | — | — |
| 2WG4 | Crystal structure of the complex between human hedgehog-interacting protein hip and sonic hedgehog… | x-ray diffraction | B | — | — |
| 3HO3 | Crystal structure of Hedgehog-interacting protein (HHIP) | x-ray diffraction | A | — | — |
| 3HO3 | Crystal structure of hedgehog-interacting protein (hhip) | x-ray diffraction | A | — | — |
| 3HO4 | Crystal structure of Hedgehog-interacting protein (HHIP) | x-ray diffraction | A, B | — | — |
| 3HO4 | Crystal structure of hedgehog-interacting protein (hhip) | x-ray diffraction | A, B | — | — |
| 3HO5 | Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex | x-ray diffraction | A, B | — | — |
| 3HO5 | Crystal structure of hedgehog-interacting protein (hhip) and sonic hedgehog (shh) complex | x-ray diffraction | A, B | — | — |
| 7PGK | HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), in complex with… | x-ray diffraction | A | GU4, YYJ | 1 (best 0.32) |
| 7PGK | Hhip-N, the N-terminal domain of the hedgehog-interacting protein (hhip), in complex with… | x-ray diffraction | A | GU4, YYJ | — |
| 7PGL | HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), apo-form | x-ray diffraction | A | — | — |
| 7PGL | Hhip-N, the N-terminal domain of the hedgehog-interacting protein (hhip), apo-form | x-ray diffraction | A | — | — |
| 7PGM | HHIP-C in complex with heparin | x-ray diffraction | A, B, C | SGN, IDS | 14 (best 0.81) |
| 7PGM | Hhip-C in complex with heparin | x-ray diffraction | A, B, C | SGN, IDS | — |
| 7PGN | HHP-C in complex with glycosaminoglycan mimic SOS | x-ray diffraction | A, B | GU4, YYJ, CA | 12 (best 0.81) |
| 7PGN | Hhp-C in complex with glycosaminoglycan mimic sos | x-ray diffraction | A, B | GU4, YYJ, CA | — |
| Q96QV1 | AlphaFold monomer V2.0 prediction for hedgehog-interacting protein (Q96QV1) | predicted | A | — | 12 (best 0.81) |
Ligands
Experiment against prediction
- 3HO4 chain A against the predicted model Q96QV1: TM-score 0.99, RMSD 0.82 Å
- 3HO4 chain A against the predicted model Q96QV1: TM-score 0.99, RMSD 0.82 Å
- 7PGM chain B against the predicted model Q96QV1: TM-score 0.99, RMSD 0.95 Å
- 7PGM chain B against the predicted model Q96QV1: TM-score 0.99, RMSD 0.95 Å
- 2WFT chain A against the predicted model Q96QV1: TM-score 0.99, RMSD 1.04 Å
- 2WFT chain A against the predicted model Q96QV1: TM-score 0.99, RMSD 1.04 Å
- 2WFT chain B against the predicted model Q96QV1: TM-score 0.99, RMSD 0.99 Å
- 2WFT chain B against the predicted model Q96QV1: TM-score 0.99, RMSD 0.99 Å
- 2WG3 chain C against the predicted model Q96QV1: TM-score 0.99, RMSD 1.01 Å
- 2WG3 chain C against the predicted model Q96QV1: TM-score 0.99, RMSD 1.01 Å
Elsewhere
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