MolNFT v1 · #66362 · protein

Crystal structure of hedgehog-interacting protein (hhip)

3HO3: “Crystal structure of hedgehog-interacting protein (hhip)”. X-ray diffraction, 3 pockets (best druggability 0.80). MolNFT v1 #66362 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3HO3
Type: protein
Length: 442 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hedgehog-interacting protein
UniProt: Q96QV1
Pockets: 3 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 2% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hedgehog-interacting protein	protein	442	2% helix, 35% strand	Q96QV1

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	815	0.80	0.83	71	empty
2	141	0.55	0.82	30	empty
3	163	0.51	0.78	27	empty

Modifications

Observed in the structure: 11 disulfide (disulfide).

Compared structures

3HO3 · Crystal structure of Hedgehog-interacting protein (HHIP) · the same entry in another collection · chain A against A, TM-score 1.00
Q96QV1 · AlphaFold monomer V2.0 prediction for hedgehog-interacting protein (Q96QV1) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96QV1
Elsewhere: RCSB PDB 3HO3 · PDBe 3HO3 · UniProt Q96QV1

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