UniProt Q8RQE9
DNA-directed RNA polymerase subunit beta (Q8RQE9)
DNA-directed RNA polymerase subunit beta (UniProt Q8RQE9), EC 2.7.7.6: 157 experimental structures and 1 predicted model on GenesisL1, 25 ligands bound, 1,492 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8RQE9
- Protein
- DNA-directed RNA polymerase subunit beta
- EC
- 2.7.7.6
- Experimental structures
- 157
- Predicted models
- 1
- Ligands
- 25
- Pockets
- 1,492 · 92 records with a druggable one
Structures
158 records of Q8RQE9 in the MolNFT archive: 157 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1SMY | Structural basis for transcription regulation by alarmone ppGpp | x-ray diffraction | C, M | MG, G4P | 18 (best 0.87) |
| 1SMY | Structural basis for transcription regulation by alarmone ppgpp | x-ray diffraction | C, M | MG, G4P | 18 (best 0.87) |
| 1ZYR | Structure of Thermus thermophilus RNA polymerase holoenzyme in complex with the antibiotic… | x-ray diffraction | C, M | — | — |
| 1ZYR | Structure of thermus thermophilus RNA polymerase holoenzyme in complex with the antibiotic… | x-ray diffraction | C, M | STD | 18 (best 0.87) |
| 2A68 | Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | C, M | — | — |
| 2A68 | Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | C, M | MG, RBT | 18 (best 0.85) |
| 2A69 | Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | C, M | — | — |
| 2A69 | Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | C, M | MG, RPT | 18 (best 0.85) |
| 2A6E | Crystal structure of the T. Thermophilus RNA polymerase holoenzyme | x-ray diffraction | C, M | — | — |
| 2A6E | Crystal structure of the T. thermophilus RNA polymerase holoenzyme | x-ray diffraction | C, M | — | 18 (best 0.84) |
| 2A6H | Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | C, M | — | — |
| 2A6H | Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | C, M | STD | 18 (best 0.85) |
| 2BE5 | Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with inhibitor… | x-ray diffraction | C, M | — | — |
| 2BE5 | Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with inhibitor… | x-ray diffraction | C, M | MG, TGT | 18 (best 0.84) |
| 2CW0 | Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution | x-ray diffraction | C, M | — | — |
| 2CW0 | Crystal structure of thermus thermophilus RNA polymerase holoenzyme at 3.3 ångströms resolution | x-ray diffraction | C, M | — | 18 (best 0.86) |
| 2O5I | Crystal structure of the T. thermophilus RNA polymerase elongation complex | x-ray diffraction | C, M | — | 17 (best 0.86) |
| 2O5I | Crystal structure of the T. thermophilus RNA polymerase elongation complex | x-ray diffraction | C, M | — | 17 (best 0.86) |
| 2O5J | Crystal structure of the T. thermophilus RNAP polymerase elongation complex with the NTP substrate… | x-ray diffraction | C, M | MG, APC | 20 (best 0.86) |
| 2O5J | Crystal structure of the T. thermophilus rnap polymerase elongation complex with the ntp substrate… | x-ray diffraction | C, M | MG, APC | 20 (best 0.86) |
| 2PPB | Crystal structure of the T. thermophilus RNAP polymerase elongation complex with the ntp substrate… | x-ray diffraction | C, M | STD, APC, MG | 20 (best 0.86) |
| 2PPB | Crystal structure of the T. thermophilus rnap polymerase elongation complex with the ntp substrate… | x-ray diffraction | C, M | STD, APC, MG | 20 (best 0.86) |
| 3AOH | RNA polymerase-Gfh1 complex (Crystal type 1) | x-ray diffraction | C, H, M | — | 19 (best 0.87) |
| 3AOH | RNA polymerase-GFH1 complex (crystal type 1) | x-ray diffraction | C, H, M | — | 19 (best 0.87) |
| 3AOI | RNA polymerase-Gfh1 complex (Crystal type 2) | x-ray diffraction | C, H, M | — | 20 (best 0.89) |
| 3AOI | RNA polymerase-GFH1 complex (crystal type 2) | x-ray diffraction | C, H, M | — | 20 (best 0.89) |
| 3DXJ | Crystal structure of thermus thermophilus rna polymerase holoenzyme in complex with the antibiotic… | x-ray diffraction | C, M | PO4, NE6 | 13 (best 0.86) |
| 3DXJ | Crystal structure of thermus thermophilus RNA polymerase holoenzyme in complex with the antibiotic… | x-ray diffraction | C, M | NE6, PO4 | 13 (best 0.86) |
| 3EQL | Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | C, M | MXP | 18 (best 0.86) |
| 3EQL | Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic… | x-ray diffraction | C, M | MXP | 18 (best 0.86) |
| 3WOD | RNA polymerase-gp39 complex | x-ray diffraction | C | — | 16 (best 0.86) |
| 3WOD | RNA polymerase-GP39 complex | x-ray diffraction | C | — | 16 (best 0.86) |
| 3WOE | Crystal structure of P23-45 gp39 (6-109) bound to Thermus thermophilus RNA polymerase beta-flap… | x-ray diffraction | A, C | — | 8 (best 0.65) |
| 3WOE | Crystal structure of P23-45 GP39 (6-109) bound to thermus thermophilus RNA polymerase beta-flap… | x-ray diffraction | A, C | — | 8 (best 0.65) |
| 3WOF | Crystal structure of P23-45 gp39 (6-132) bound to Thermus thermophilus RNA polymerase beta-flap… | x-ray diffraction | A, C, E, G, I, K, M, O, Q, S, U, W | — | 18 (best 0.79) |
| 3WOF | Crystal structure of P23-45 GP39 (6-132) bound to thermus thermophilus RNA polymerase beta-flap… | x-ray diffraction | A, C, E, G, I, K, M, O, Q, S, U, W | — | 18 (best 0.79) |
| 4G7H | Crystal structure of Thermus thermophilus transcription initiation complex | x-ray diffraction | C, M | — | 15 (best 0.87) |
| 4G7H | Crystal structure of thermus thermophilus transcription initiation complex | x-ray diffraction | C, M | — | — |
| 4G7O | Crystal structure of Thermus thermophilus transcription initiation complex containing 2 nt of RNA | x-ray diffraction | C, M | — | 14 (best 0.86) |
| 4G7O | Crystal structure of thermus thermophilus transcription initiation complex containing 2 nt of RNA | x-ray diffraction | C, M | — | — |
| 4G7Z | Crystal structure of Thermus thermophilus transcription initiation complex containing 5-BrU at… | x-ray diffraction | C, M | — | 17 (best 0.86) |
| 4G7Z | Crystal structure of thermus thermophilus transcription initiation complex containing 5-bru at… | x-ray diffraction | C, M | — | — |
| 4GZY | Crystal structures of bacterial RNA Polymerase paused elongation complexes | x-ray diffraction | C | — | 15 (best 0.87) |
| 4GZY | Crystal structures of bacterial RNA polymerase paused elongation complexes | x-ray diffraction | C | — | — |
| 4GZZ | Crystal structures of bacterial RNA Polymerase paused elongation complexes | x-ray diffraction | C | — | 14 (best 0.87) |
| 4GZZ | Crystal structures of bacterial RNA polymerase paused elongation complexes | x-ray diffraction | C | — | — |
| 4MQ9 | Crystal structure of Thermus thermophilus RNA polymerase holoenzyme in complex with GE23077 | x-ray diffraction | C | MB8 | 16 (best 0.81) |
| 4MQ9 | Crystal structure of thermus thermophilus RNA polymerase holoenzyme in complex with GE23077 | x-ray diffraction | C | — | — |
| 4OIN | Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077 | x-ray diffraction | C | MB8 | 17 (best 0.87) |
| 4OIN | Crystal structure of thermus thermophilus transcription initiation complex soaked with GE23077 | x-ray diffraction | C | — | — |
| 4OIO | Crystal structure of Thermus thermophilus pre-insertion substrate complex for de novo transcription… | x-ray diffraction | C | MG, ATP, 2TM | 17 (best 0.86) |
| 4OIO | Crystal structure of thermus thermophilus pre-insertion substrate complex for de novo transcription… | x-ray diffraction | C | — | — |
| 4OIP | Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077… | x-ray diffraction | C | MG, ATP, MB8 | 16 (best 0.86) |
| 4OIP | Crystal structure of thermus thermophilus transcription initiation complex soaked with GE23077… | x-ray diffraction | C | — | — |
| 4OIQ | Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077 and… | x-ray diffraction | C | — | 17 (best 0.87) |
| 4OIQ | Crystal structure of thermus thermophilus transcription initiation complex soaked with GE23077 and… | x-ray diffraction | C | — | — |
| 4OIR | Crystal structure of Thermus thermophilus RNA polymerase transcription initiation complex soaked… | x-ray diffraction | C | RFV | 16 (best 0.87) |
| 4OIR | Crystal structure of thermus thermophilus RNA polymerase transcription initiation complex soaked… | x-ray diffraction | C | — | — |
| 4Q4Z | Thermus thermophilus RNA polymerase de novo transcription initiation complex | x-ray diffraction | C | ATP, 2TM | 18 (best 0.87) |
| 4Q4Z | Thermus thermophilus RNA polymerase de novo transcription initiation complex | x-ray diffraction | C | — | — |
98 records more on the page itself.
Ligands
- MG · Magnesium ion · in 29 records
- POP · Pyrophosphate 2- · in 10 records
- 2TM · 5'-O-[(S)-hydroxy{[(s)-hydroxy(phosphonooxy) phosphoryl]methyl}phosphoryl]cytidine · in 8 records
- APC · Diphosphomethylphosphonic acid adenosyl ester · in 4 records
- ATP · Adenosine-5'-triphosphate · in 4 records
- G4P · Guanosine-5',3'-tetraphosphate · in 4 records
- GTP · Guanosine-5'-triphosphate · in 4 records
- NE6 · Methyl [(1E,5R)-5-{(3S)-3-[(2E,4E)-2,5-dimethylocta-2, 4-dienoyl]-2,4-dioxo-3,4-dihydro-2H-pyran-6-yl}hexylidene]carbamate · in 4 records
- STD · Streptolydigin · in 4 records
- MB8 · (2Z)-2-methylbut-2-enoic acid · in 3 records
- PO4 · Phosphate ion · in 3 records
- CH1 · 3'-deoxy-cytidine-5'-triphosphate · in 2 records
- DCP · 2'-deoxycytidine-5'-triphosphate · in 2 records
- MXP · Myxopyronin B · in 2 records
- NA · Sodium ion · in 2 records
- PUM · (1S)-1,4-anhydro-5-[(N-carbamimidoylglycyl-N~2~-hydroxy-L-glutaminyl)amino]-5-deoxy-1-(2,4-dioxo-1,2, 3,4-tetrahydropyrimidin-5-yl)-D-ribitol · in 2 records
- UTP · Uridine 5'-triphosphate · in 2 records
- C5P · Cytidine-5'-monophosphate · in 1 record
- COD · Dephospho coenzyme A · in 1 record
- DGP · 2'-deoxyguanosine-5'-monophosphate · in 1 record
- DPO · Diphosphate · in 1 record
- RBT · Rifabutin · in 1 record
- RFV · rifamycin SV · in 1 record
- RPT · Rifapentine · in 1 record
- TGT · Tagetitoxin · in 1 record
Experiment against prediction
- 4OIQ chain C against the predicted model Q8RQE9: TM-score 0.98, RMSD 1.43 Å
- 4OIQ chain C against the predicted model Q8RQE9: TM-score 0.98, RMSD 1.43 Å
- 5X21 chain C against the predicted model Q8RQE9: TM-score 0.98, RMSD 1.37 Å
- 4OIR chain C against the predicted model Q8RQE9: TM-score 0.98, RMSD 1.46 Å
- 4OIR chain C against the predicted model Q8RQE9: TM-score 0.98, RMSD 1.46 Å
- 5X22 chain M against the predicted model Q8RQE9: TM-score 0.98, RMSD 1.49 Å
- 5D4E chain M against the predicted model Q8RQE9: TM-score 0.98, RMSD 1.51 Å
- 7RDQ chain C against the predicted model Q8RQE9: TM-score 0.98, RMSD 1.57 Å
- 7MLB chain C against the predicted model Q8RQE9: TM-score 0.98, RMSD 1.41 Å
- 7MLI chain C against the predicted model Q8RQE9: TM-score 0.98, RMSD 1.42 Å
Elsewhere
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