UniProt Q8N8S7

Protein enabled homolog (Q8N8S7)

Protein enabled homolog (UniProt Q8N8S7): 49 experimental structures and 1 predicted model on GenesisL1, 22 ligands bound, 25 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: Q8N8S7
Protein: Protein enabled homolog
Experimental structures: 49
Predicted models: 1
Ligands: 22
Pockets: 25 · 5 records with a druggable one

Structures

50 records of Q8N8S7 in the MolNFT archive: 49 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
2HO2	Structure of human FE65-WW domain in complex with hMena peptide.	x-ray diffraction	B	—	—
2HO2	Structure of human FE65-ww domain in complex with hmena peptide.	x-ray diffraction	B	—	—
2IYB	Structure of complex between the 3rd LIM domain of TES and the EVH1 domain of Mena	x-ray diffraction	A, B, C, D	—	—
2IYB	Structure of complex between the 3RD lim domain of tes and the EVH1 domain of mena	x-ray diffraction	A, B, C, D	—	—
2XQN	Complex of the 2nd and 3rd LIM domains of TES with the EVH1 DOMAIN of MENA and the N-Terminal…	x-ray diffraction	M	—	—
2XQN	Complex of the 2ND and 3RD lim domains of tes with the EVH1 domain of mena and the N-terminal…	x-ray diffraction	M	—	—
4MY6	EnaH-EVH1 in complex with peptidomimetic low-molecular weight inhibitor…	x-ray diffraction	A, B	—	—
4MY6	Enah-EVH1 in complex with peptidomimetic low-molecular weight inhibitor…	x-ray diffraction	A, B	—	—
5N91	ENAH EVH1 in complex with Ac-[2-Cl-F]-PPPP-OH	x-ray diffraction	A, B	NO3	1 (best 0.60)
5N91	Enah EVH1 in complex with ac-[2-cl-F]-pppp-oh	x-ray diffraction	A, B	ACE, 2L5, NO3	—
5N9C	ENAH EVH1 in complex with Ac-[2-Cl-F]-PP-[ProM-1]-OH	x-ray diffraction	A, B	SO4, NO3	3 (best 0.51)
5N9C	Enah EVH1 in complex with ac-[2-cl-F]-pp-[prom-1]-oh	x-ray diffraction	A, B	ACE, 2L5, 92B, SO4, NO3	—
5N9P	ENAH EVH1 in complex with Ac-[2-Cl-F]-PP-[ProM-1]-NH2	x-ray diffraction	B, A	CL	1 (best 0.27)
5N9P	Enah EVH1 in complex with ac-[2-cl-F]-pp-[prom-1]-NH2	x-ray diffraction	B, A	ACE, 2L5, 92B, CL	—
5NAJ	ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-1]-[ProM-1]-OH	x-ray diffraction	A, B, C, D	8SE, SO4, 8SB, CL	—
5NAJ	Enah EVH1 in complex with ac-[2-cl-F]-[prom-1]-[prom-1]-oh	x-ray diffraction	A, B, C, D	8SE, SO4, 8SB, CL	—
5NBF	ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-3]-OH	x-ray diffraction	A	8S8, SO4, NO3	—
5NBF	Enah EVH1 in complex with ac-[2-cl-F]-[prom-2]-[prom-3]-oh	x-ray diffraction	A	8S8, SO4, NO3	—
5NBX	ENAH EVH1 in complex with Ac-[2-Cl-F]-PP-[ProM-9]-OH	x-ray diffraction	A, B	BR	—
5NBX	Enah EVH1 in complex with ac-[2-cl-F]-pp-[prom-9]-oh	x-ray diffraction	A, B	BR, 2L5, 8SN	—
5NC2	ENAH EVH1 in complex with Ac-[2-Cl-F]-PPPPTEDEL-NH2	x-ray diffraction	A, B	SO4, NO3	1 (best 0.34)
5NC2	Enah EVH1 in complex with ac-[2-cl-F]-pppptedel-NH2	x-ray diffraction	A, B	ACE, 2L5, SO4, NO3	—
5NC7	ENAH EVH1 in complex with Ac-WPPPPTEDEL-NH2	x-ray diffraction	A, B, C, D	—	6 (best 0.54)
5NC7	Enah EVH1 in complex with ac-wpppptedel-NH2	x-ray diffraction	A, B, C, D	ACE	—
5NCF	ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-4]-OH	x-ray diffraction	A, B	8T5, SO4, NO3	3 (best 0.30)
5NCF	Enah EVH1 in complex with ac-[2-cl-F]-[prom-2]-[prom-4]-oh	x-ray diffraction	A, B	8T5, SO4, NO3	—
5NCG	ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-9]-OH	x-ray diffraction	A, B	8TB, NO3	1 (best 0.37)
5NCG	Enah EVH1 in complex with ac-[2-cl-F]-[prom-2]-[prom-9]-oh	x-ray diffraction	A, B	8TB, NO3	—
5NCP	ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-12]-OH	x-ray diffraction	A	EG5, NO3, SO4	—
5NCP	Enah EVH1 in complex with ac-[2-cl-F]-[prom-2]-[prom-12]-oh	x-ray diffraction	A	EG5, NO3, SO4	—
5ND0	ENAH EVH1 in complex with Ac-[2-Cl-F]-PP-[ProM-1]-TEDEL-NH2	x-ray diffraction	A, B	SO4, NO3	3 (best 0.35)
5ND0	Enah EVH1 in complex with ac-[2-cl-F]-pp-[prom-1]-tedel-NH2	x-ray diffraction	A, B	ACE, 2L5, 8TQ, SO4, NO3	—
5NDU	ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-12]-OMe	x-ray diffraction	A, B	8V2, SO4, NO3	1 (best 0.30)
5NDU	Enah EVH1 in complex with ac-[2-cl-F]-[prom-2]-[prom-12]-ome	x-ray diffraction	A, B	8V2, SO4, NO3	—
5NEG	ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-13]-OEt	x-ray diffraction	A, B	8VK, NO3, SO4	1 (best 0.53)
5NEG	Enah EVH1 in complex with ac-[2-cl-F]-[prom-2]-[prom-13]-oet	x-ray diffraction	A, B	8VK, NO3, SO4	—
6RCF	ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-15]-OH	x-ray diffraction	A	K0K, NO3	—
6RCF	Enah EVH1 in complex with ac-[2-cl-F]-[prom-2]-[prom-15]-oh	x-ray diffraction	A	NO3	—
6RCJ	ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-15]-OMe	x-ray diffraction	A	K0H, NO3	—
6RCJ	Enah EVH1 in complex with ac-[2-cl-F]-[prom-2]-[prom-15]-ome	x-ray diffraction	A	NO3	—
6RD2	ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-1]-TEDEL-NH2	x-ray diffraction	B, A	NO3, K1N	3 (best 0.51)
6RD2	Enah EVH1 in complex with ac-[2-cl-F]-[prom-2]-[prom-1]-tedel-NH2	x-ray diffraction	B, A	NO3	—
6XVT	ENAH EVH1 in complex with Ac-[2-Cl-F]-PPPPTEDDL-NH2	x-ray diffraction	A, B	NO3, SO4	—
6XVT	Enah EVH1 in complex with ac-[2-cl-F]-ppppteddl-NH2	x-ray diffraction	A, B	2L5, NO3, SO4	—
6XXR	ENAH EVH1 in complex with Ac-[2-Cl-F]-PPPPTEDEA-NH2	x-ray diffraction	A, B	NO3	1 (best 0.39)
6XXR	Enah EVH1 in complex with ac-[2-cl-F]-pppptedea-NH2	x-ray diffraction	A, B	2L5, NO3	—
7A5M	ENAH EVH1 in complex with Ac-[2-Cl-F]-[ProM-2]-[ProM-17]-OMe	x-ray diffraction	A	NO3	—
7A5M	Enah EVH1 in complex with ac-[2-cl-F]-[prom-2]-[prom-17]-ome	x-ray diffraction	A	2L5, 2L6, R0E, NO3	—
7AKI	Enah EVH1 in complex with ac-[2-cl-F]-[prom-2]-[prom-1]-NH2	x-ray diffraction	A	NO3	—
Q8N8S7	AlphaFold monomer V2.0 prediction for protein enabled homolog (Q8N8S7)	predicted	A	—	—

Ligands

NO3 · Nitrate ion · in 33 records
SO4 · Sulfate ion · in 20 records
2L5 · 2-chloro-L-phenylalanine · in 9 records
ACE · Acetyl group · in 6 records
CL · Chloride ion · in 4 records
8S8 · (3~{S},6~{S},7~{R},9~{A}~{R})-6-[[(3~{S},6~{R}, 8~{A}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl) propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonylamino]-7-methyl-5-oxidanylidene-1,2,3,6,7, 9~{A}-hexahydropyrrolo[1,2-a]azepine-3-carboxylic acid · in 2 records
8SB · (3~{S},7~{R},10~{R},13~{S})-4-[[(3~{R},7~{S},10~{S}, 13~{R})-4-[(2~{S})-2-acetamido-3-(2-chlorophenyl) propanoyl]-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-en-13-yl]carbonyl]-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylic acid · in 2 records
8SE · (3~{S},7~{R},10~{R},13~{S})-4-[[(3~{S},7~{R},10~{R}, 13~{S})-4-[(2~{S})-2-acetamido-3-(2-chlorophenyl) propanoyl]-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-en-13-yl]carbonyl]-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylic acid · in 2 records
8T5 · (1~{S},4~{S},7~{R},10~{R})-14-[(3~{S},6~{R},8~{A}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-2-oxidanylidene-3,14-diazatricyclo[8.4.0.0^{3, 7}]tetradec-8-ene-4-carboxylic acid · in 2 records
8TB · (3~{S},7~{R},10~{R},11~{R},13~{S})-4-[(3~{S},6~{R}, 8~{A}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl) propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-11-methyl-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylic acid · in 2 records
8V2 · Methyl (3~{S},7~{R},10~{R},13~{R})-4-[(3~{S},6~{R}, 8~{A}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl) propanoyl]-5-oxidanylid ene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3, 7}]tridec-8-ene-13-carboxylate · in 2 records
8VK · Ethyl (3~{S},7~{R},10~{R},11~{R},13~{S})-4-[(3~{S}, 6~{R},8~{A}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3, 8~{A}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-11-ethyl-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylate · in 2 records
92B · (3~{S},7~{R},10~{R},13~{S})-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylic acid · in 2 records
BR · Bromide ion · in 2 records
EG5 · (3~{S},7~{R},10~{R},13~{R})-4-[(3~{S},6~{R},8~{A}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3, 7}]tridec-8-ene-13-carboxylic acid · in 2 records
2L6 · (3s,6r,8as)-5-oxo-1,2,3,8A-tetrahydrospiro[indolizine-6,2'-pyrrolidine]-3-carboxylic acid · in 1 record
8SN · (3~{S},7~{R},10~{R},11~{R},13~{S})-11-methyl-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylic acid · in 1 record
8TQ · (3~{S},7~{R},10~{R},13~{S})-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carbaldehyde · in 1 record
K0H · methyl 2-[(3~{a}~{R},6~{R},8~{a}~{S})-1-[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-6-ethyl-8-oxidanylidene-3,3~{a},6,8~{a}-tetrahydro-2~{H}-pyrrolo[2,3-c]azepin-7-yl]ethanoate · in 1 record
K0K · 2-[(3~{a}~{R},6~{R},8~{a}~{S})-1-[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-6-ethyl-8-oxidanylidene-3,3~{a},6,8~{a}-tetrahydro-2~{H}-pyrrolo[2,3-c]azepin-7-yl]ethanoic acid · in 1 record
K1N · (3~{S},7~{R},10~{R},13~{S})-4-[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylic acid · in 1 record
R0E · Prom-17 · in 1 record

Experiment against prediction

5NDU chain A against the predicted model Q8N8S7: TM-score 0.99, RMSD 0.42 Å
5NDU chain A against the predicted model Q8N8S7: TM-score 0.99, RMSD 0.42 Å
5NC7 chain A against the predicted model Q8N8S7: TM-score 0.99, RMSD 0.44 Å
5NC7 chain A against the predicted model Q8N8S7: TM-score 0.99, RMSD 0.44 Å
6XVT chain B against the predicted model Q8N8S7: TM-score 0.99, RMSD 0.44 Å
6XVT chain B against the predicted model Q8N8S7: TM-score 0.99, RMSD 0.44 Å
5NCP chain A against the predicted model Q8N8S7: TM-score 0.99, RMSD 0.44 Å
5NCP chain A against the predicted model Q8N8S7: TM-score 0.99, RMSD 0.44 Å
5NC7 chain C against the predicted model Q8N8S7: TM-score 0.99, RMSD 0.46 Å
5NC7 chain C against the predicted model Q8N8S7: TM-score 0.99, RMSD 0.46 Å

Elsewhere

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