MolNFT v1 · #54493 · protein
Complex of the 2ND and 3RD lim domains of tes with the EVH1 domain of mena and the N-terminal domain of actin-like protein ARP7A
2XQN · Actin-like protein 7A: “Complex of the 2ND and 3RD lim domains of tes with the EVH1 domain of mena and the N-terminal domain of…”. X-ray diffraction, 1 ligand (ZN), 2 pockets (best druggability 0.71). MolNFT v1 #54493 on GenesisL1…
- PDB
- 2XQN
- Type
- protein
- Length
- 263 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actin-like protein 7A; Enabled homolog; Testin
- UniProt
- Q9Y615, Q8N8S7, Q9UGI8
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.71
Structure
x-ray diffraction · 3 distinct chains · 14% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Actin-like protein 7A | protein | 22 | 0% helix, 41% strand | Q9Y615 |
| M | Enabled homolog | protein | 116 | 19% helix, 47% strand | Q8N8S7 |
| T | Testin | protein | 125 | 12% helix, 33% strand | Q9UGI8 |
Ligands and binding sites
- ZN · Zinc ion · metal · 5 copies · chains T
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 130 | 0.71 | 0.92 | 32 | empty |
| 2 | 83 | 0.34 | 0.75 | 20 | empty |
Interfaces
2 interfaces between chains.
- A–T · 1247 Ų buried · 22 hydrogen bonds · protein-protein
- M–T · 654 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 2XQN · Complex of the 2nd and 3rd LIM domains of TES with the EVH1 DOMAIN of MENA and the… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UGI8 · AlphaFold monomer V2.0 prediction for testin (Q9UGI8) · a predicted model of the same protein · chain T against A, TM-score 0.98
- Q8N8S7 · AlphaFold monomer V2.0 prediction for protein enabled homolog (Q8N8S7) · a predicted model of the same protein · chain M against A, TM-score 0.94
- Q9Y615 · AlphaFold monomer V2.0 prediction for actin-like protein 7A (Q9Y615) · a predicted model of the same protein · chain A against A, TM-score 0.21
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y615
- Every structure of UniProt Q8N8S7
- Every structure of UniProt Q9UGI8
- Elsewhere: RCSB PDB 2XQN · PDBe 2XQN · UniProt Q9Y615 · UniProt Q8N8S7 · UniProt Q9UGI8
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