UniProt Q8K424
Transient receptor potential cation channel subfamily V member 3 (Q8K424)
Transient receptor potential cation channel subfamily V member 3 (UniProt Q8K424): 38 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 270 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q8K424
- Protein
- Transient receptor potential cation channel subfamily V member 3
- Experimental structures
- 38
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 270 · 14 records with a druggable one
Structures
39 records of Q8K424 in the MolNFT archive: 38 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4N5Q | Crystal structure of the N-terminal ankyrin repeat domain of TRPV3 | x-ray diffraction | A, B | — | — |
| 4N5Q | Crystal structure of the N-terminal ankyrin repeat domain of TRPV3 | x-ray diffraction | A, B | — | — |
| 6DVW | Cryo-EM structure of mouse TRPV3 | electron microscopy | A, B, C, D | — | 20 (best 0.85) |
| 6DVW | Cryo-EM structure of mouse TRPV3 | electron microscopy | A, B, C, D | — | — |
| 6DVY | Cryo-EM structure of mouse TRPV3 in complex with 2-Aminoethoxydiphenyl borate (2-APB) | electron microscopy | A, B, C, D | FZ4 | — |
| 6DVY | Cryo-EM structure of mouse TRPV3 in complex with 2-aminoethoxydiphenyl borate (2-apb) | electron microscopy | A, B, C, D | FZ4 | — |
| 6DVZ | Cryo-EM structure of mouse TRPV3-Y564A in complex with 2-Aminoethoxydiphenyl borate (2-APB) | electron microscopy | A, B, C, D | FZ4 | 20 (best 0.84) |
| 6DVZ | Cryo-EM structure of mouse TRPV3-Y564A in complex with 2- aminoethoxydiphenyl borate (2-apb) | electron microscopy | A, B, C, D | FZ4 | — |
| 6LGP | cryo-EM structure of TRPV3 in lipid nanodisc | electron microscopy | A, B, C, D | POV, PLC | — |
| 6LGP | Cryo-EM structure of TRPV3 in lipid nanodisc | electron microscopy | A, B, C, D | POV, PLC | — |
| 6PVL | Cryo-EM structure of mouse TRPV3 in closed state at 42 degrees Celsius | electron microscopy | A, B, C, D | — | 20 (best 0.81) |
| 6PVL | Cryo-EM structure of mouse TRPV3 in closed state at 42 degrees celsius | electron microscopy | A, B, C, D | — | — |
| 6PVM | Cryo-EM structure of mouse TRPV3 in putative sensitized state at 42 degrees Celsius | electron microscopy | A, B, C, D | — | — |
| 6PVM | Cryo-EM structure of mouse TRPV3 in putative sensitized state at 42 degrees celsius | electron microscopy | A, B, C, D | — | — |
| 6PVN | Cryo-EM structure of mouse TRPV3-Y564A in putative sensitized state at 4 degrees Celsius | electron microscopy | A, B, C, D | NA | 20 (best 0.86) |
| 6PVN | Cryo-EM structure of mouse TRPV3-Y564A in putative sensitized state at 4 degrees celsius | electron microscopy | A, B, C, D | NA | — |
| 6PVO | Cryo-EM structure of mouse TRPV3-Y564A in putative sensitized state at 37 degrees celsius | electron microscopy | A, B, C, D | — | — |
| 6PVP | Cryo-EM structure of mouse TRPV3-Y564A in open state at 37 degrees Celsius | electron microscopy | A, B, C, D | — | — |
| 6PVP | Cryo-EM structure of mouse TRPV3-Y564A in open state at 37 degrees celsius | electron microscopy | A, B, C, D | — | — |
| 6PVQ | Cryo-EM structure of mouse TRPV3-Y564A in intermediate state at 37 degrees Celsius | electron microscopy | A, B, C, D | — | 20 (best 0.79) |
| 6PVQ | Cryo-EM structure of mouse TRPV3-Y564A in intermediate state at 37 degrees celsius | electron microscopy | A, B, C, D | — | — |
| 7MIJ | Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 4 degrees Celsius | electron microscopy | A, B, C, D | POV, NA | 20 (best 0.85) |
| 7MIJ | Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 4 degrees celsius | electron microscopy | A, B, C, D | POV, NA | — |
| 7MIK | Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 42 degrees Celsius | electron microscopy | A, B, C, D | POV, NA | 20 (best 0.84) |
| 7MIK | Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 42 degrees celsius | electron microscopy | A, B, C, D | POV, NA | — |
| 7MIL | Mouse TRPV3 in MSP2N2 nanodiscs, sensitized state at 42 degrees Celsius | electron microscopy | A, B, C, D | POV | 20 (best 0.82) |
| 7MIL | Mouse TRPV3 in MSP2N2 nanodiscs, sensitized state at 42 degrees celsius | electron microscopy | A, B, C, D | POV | — |
| 7MIM | Mouse TRPV3 in cNW11 nanodiscs, closed state at 4 degrees Celsius | electron microscopy | A, B, C, D | POV, NA | 20 (best 0.84) |
| 7MIM | Mouse TRPV3 in CNW11 nanodiscs, closed state at 4 degrees celsius | electron microscopy | A, B, C, D | POV, NA | — |
| 7MIN | Mouse TRPV3 in cNW11 nanodiscs, closed state at 42 degrees Celsius | electron microscopy | A, B, C, D | POV, NA | 20 (best 0.84) |
| 7MIN | Mouse TRPV3 in CNW11 nanodiscs, closed state at 42 degrees celsius | electron microscopy | A, B, C, D | POV, NA | — |
| 7MIO | Mouse TRPV3 in CNW11 nanodiscs, open state at 42 degrees celsius | electron microscopy | A, B, C, D | POV | — |
| 7RAS | Structure of TRPV3 in complex with osthole | electron microscopy | A, B, C, D | A0O | 20 (best 0.70) |
| 7RAS | Structure of TRPV3 in complex with osthole | electron microscopy | A, B, C, D | A0O | — |
| 7RAU | Structure of TRPV3 in complex with osthole | electron microscopy | A, B, C, D | A0O | 20 (best 0.79) |
| 7RAU | Structure of TRPV3 in complex with osthole | electron microscopy | A, B, C, D | A0O | — |
| 7UGG | Cryo-EM structure of TRPV3 in complex with the anesthetic dyclonine | electron microscopy | A, B, C, D | POV, N8R, NA | 20 (best 0.84) |
| 7UGG | Cryo-EM structure of TRPV3 in complex with the anesthetic dyclonine | electron microscopy | A, B, C, D | POV, N8R, NA | — |
| Q8K424 | AlphaFold monomer V2.0 prediction for transient receptor potential cation channel subfamily V… | predicted | A | — | 10 (best 0.72) |
Ligands
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 15 records
- NA · Sodium ion · in 12 records
- A0O · 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one · in 4 records
- FZ4 · 2-aminoethyl diphenylborinate · in 4 records
- N8R · Dyclonine · in 2 records
- PLC · Diundecyl phosphatidyl choline · in 2 records
Experiment against prediction
- 6LGP chain A against the predicted model Q8K424: TM-score 0.97, RMSD 1.70 Å
- 6LGP chain A against the predicted model Q8K424: TM-score 0.97, RMSD 1.70 Å
- 7MIK chain B against the predicted model Q8K424: TM-score 0.96, RMSD 1.91 Å
- 7MIK chain A against the predicted model Q8K424: TM-score 0.96, RMSD 1.91 Å
- 7MIK chain A against the predicted model Q8K424: TM-score 0.96, RMSD 1.91 Å
- 7MIK chain C against the predicted model Q8K424: TM-score 0.96, RMSD 1.91 Å
- 7MIK chain D against the predicted model Q8K424: TM-score 0.96, RMSD 1.91 Å
- 7MIN chain D against the predicted model Q8K424: TM-score 0.95, RMSD 1.97 Å
- 7MIN chain A against the predicted model Q8K424: TM-score 0.95, RMSD 1.97 Å
- 7MIN chain A against the predicted model Q8K424: TM-score 0.95, RMSD 1.97 Å
Elsewhere
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