MolNFT v1 · #182161 · protein

Mouse TRPV3 in CNW11 nanodiscs, open state at 42 degrees celsius

7MIO · Transient receptor potential cation channel subfamily V…: “Mouse TRPV3 in CNW11 nanodiscs, open state at 42 degrees celsius”. Electron microscopy, 2 ligands (POV, NA), 20 pockets (best druggability 0.83). MolNFT v1 #182161 on…

PDB: 7MIO
Type: protein
Length: 2,636 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transient receptor potential cation channel subfamily V member 3
UniProt: Q8K424
Ligands: POV, NA
Pockets: 20 · best druggability 0.83

Structure

electron microscopy · 1 distinct chain · 53% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Transient receptor potential cation channel subfamily V member 3	protein	659	53% helix, 5% strand	Q8K424

Ligands and binding sites

POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · ligand · 28 copies · chains A, B, D, C
NA · Sodium ion · metal

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1181	0.83	0.84	83	NA
2	449	0.72	0.81	34	POV
3	466	0.71	0.81	37	POV
4	452	0.71	0.81	37	POV
5	466	0.70	0.80	39	POV

Interfaces

4 interfaces between chains.

A–D · 3206 Å² buried · 16 hydrogen bonds · protein-protein
C–D · 3199 Å² buried · 16 hydrogen bonds · protein-protein
A–B · 3199 Å² buried · 16 hydrogen bonds · protein-protein
B–C · 3189 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

7MIO · Mouse TRPV3 in cNW11 nanodiscs, open state at 42 degrees Celsius · the same entry in another collection · chain A against A, TM-score 1.00
Q8K424 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8K424
Elsewhere: RCSB PDB 7MIO · PDBe 7MIO · UniProt Q8K424

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