MolNFT v1 · #478278 · protein
AlphaFold monomer V2.0 prediction for transient receptor potential cation channel subfamily V member 3 (Q8K424)
Q8K424: “AlphaFold monomer V2.0 prediction for transient receptor potential cation channel subfamily V member 3…”. 10 pockets (best druggability 0.72). MolNFT v1 #478278 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q8K424
- Type
- protein
- Length
- 791 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x80D2ac0F5e3268bC5C1d28BBAA07E3169BB02b79
- Molecule
- Transient receptor potential cation channel subfamily V member 3
- UniProt
- Q8K424
- Pockets
- 10 · best druggability 0.72
Structure
1 distinct chain · 52% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transient receptor potential cation channel subfamily V member 3 | protein | 791 | 52% helix, 4% strand | Q8K424 |
Pockets
10 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 856 | 0.72 | 0.77 | 71 | empty |
| 2 | 730 | 0.69 | 0.76 | 57 | empty |
| 3 | 218 | 0.65 | 0.83 | 26 | empty |
| 4 | 201 | 0.65 | 0.84 | 26 | empty |
| 5 | 218 | 0.55 | 0.78 | 26 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6PVP · Cryo-EM structure of mouse TRPV3-Y564A in open state at 37 degrees Celsius · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 6PVP · Cryo-EM structure of mouse TRPV3-Y564A in open state at 37 degrees celsius · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 6PVO · Cryo-EM structure of mouse TRPV3-Y564A in putative sensitized state at 37 degrees Celsius · an experimental structure of the same protein · chain A against B, TM-score 0.78
- 6PVO · Cryo-EM structure of mouse TRPV3-Y564A in putative sensitized state at 37 degrees celsius · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 7MIK · Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 42 degrees Celsius · an experimental structure of the same protein · chain A against B, TM-score 0.78
- 7MIK · Mouse TRPV3 in MSP2N2 nanodiscs, closed state at 42 degrees celsius · an experimental structure of the same protein · chain A against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8K424
- Elsewhere: UniProt Q8K424 · AlphaFold DB Q8K424
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