MolNFT v1 · #146887 · protein

Cryo-EM structure of mouse TRPV3

6DVW · Transient receptor potential cation channel subfamily V…: “Cryo-EM structure of mouse TRPV3”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #146887 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6DVW
Type: protein
Length: 2,576 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transient receptor potential cation channel subfamily V member 3
UniProt: Q8K424
Pockets: 20 · best druggability 0.85

Structure

electron microscopy · 1 distinct chain · 53% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Transient receptor potential cation channel subfamily V member 3	protein	644	53% helix, 2% strand	Q8K424

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	970	0.85	0.85	101	empty
2	816	0.79	0.82	78	empty
3	1010	0.78	0.80	83	empty
4	1057	0.78	0.80	90	empty
5	837	0.77	0.80	70	empty

Interfaces

4 interfaces between chains.

A–D · 2850 Å² buried · 15 hydrogen bonds · protein-protein
C–D · 2841 Å² buried · 15 hydrogen bonds · protein-protein
A–B · 2840 Å² buried · 15 hydrogen bonds · protein-protein
B–C · 2834 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

6DVW · Cryo-EM structure of mouse TRPV3 · the same entry in another collection · chain A against A, TM-score 1.00
Q8K424 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8K424
Elsewhere: RCSB PDB 6DVW · PDBe 6DVW · UniProt Q8K424

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