MolNFT v1 · #160829 · protein
Cryo-EM structure of mouse TRPV3-Y564A in putative sensitized state at 4 degrees celsius
6PVN · Transient receptor potential cation channel subfamily V…: “Cryo-EM structure of mouse TRPV3-Y564A in putative sensitized state at 4 degrees celsius”. Electron microscopy, 1 ligand (NA), 20 pockets (best druggability 0.86). MolNFT v1…
- PDB
- 6PVN
- Type
- protein
- Length
- 2,576 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily V member 3
- UniProt
- Q8K424
- Ligands
- NA
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 1 distinct chain · 49% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Transient receptor potential cation channel subfamily V member 3 | protein | 644 | 49% helix, 2% strand | Q8K424 |
Ligands and binding sites
- NA · Sodium ion · metal · 2 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 488 | 0.86 | 0.92 | 36 | empty |
| 2 | 685 | 0.76 | 0.81 | 61 | empty |
| 3 | 254 | 0.71 | 0.86 | 33 | empty |
| 4 | 272 | 0.70 | 0.84 | 35 | empty |
| 5 | 248 | 0.69 | 0.85 | 24 | NA |
Interfaces
6 interfaces between chains.
- B–C · 2972 Ų buried · 10 hydrogen bonds · protein-protein
- A–D · 2931 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 2931 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 2906 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 23 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6PVN · Cryo-EM structure of mouse TRPV3-Y564A in putative sensitized state at 4 degrees Celsius · the same entry in another collection · chain A against A, TM-score 1.00
- Q8K424 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8K424
- Elsewhere: RCSB PDB 6PVN · PDBe 6PVN · UniProt Q8K424
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.