MolNFT v1 · #186343 · protein

Structure of TRPV3 in complex with osthole

7RAU · Transient receptor potential cation channel subfamily V…: “Structure of TRPV3 in complex with osthole”. Electron microscopy, 1 ligand (A0O), 20 pockets (best druggability 0.79). MolNFT v1 #186343 on GenesisL1: 3D structure, binding…

PDB: 7RAU
Type: protein
Length: 2,440 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transient receptor potential cation channel subfamily V member 3
UniProt: Q8K424
Ligands: A0O
Pockets: 20 · best druggability 0.79

Structure

electron microscopy · 1 distinct chain · 58% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Transient receptor potential cation channel subfamily V member 3	protein	610	58% helix, 5% strand	Q8K424

Ligands and binding sites

A0O · 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one · ligand · 8 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	835	0.79	0.82	98	empty
2	709	0.77	0.81	63	empty
3	424	0.77	0.85	58	empty
4	400	0.76	0.86	62	empty
5	638	0.76	0.81	56	empty

Interfaces

4 interfaces between chains.

A–D · 2179 Å² buried · 9 hydrogen bonds · protein-protein
B–C · 2168 Å² buried · 9 hydrogen bonds · protein-protein
A–B · 2167 Å² buried · 11 hydrogen bonds · protein-protein
C–D · 2160 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

7RAU · Structure of TRPV3 in complex with osthole · the same entry in another collection · chain A against A, TM-score 1.00
Q8K424 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8K424
Elsewhere: RCSB PDB 7RAU · PDBe 7RAU · UniProt Q8K424

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.