UniProt Q6NZB1
Protein arginine N-methyltransferase 6 (Q6NZB1)
Protein arginine N-methyltransferase 6 (UniProt Q6NZB1), EC 2.1.1.-, 2.1.1.125: 36 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 41 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q6NZB1
- Protein
- Protein arginine N-methyltransferase 6
- EC
- 2.1.1.-, 2.1.1.125, 2.1.1.319
- Experimental structures
- 36
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 41 · 11 records with a druggable one
Structures
37 records of Q6NZB1 in the MolNFT archive: 36 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4C03 | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 reduced | x-ray diffraction | A, B | — | — |
| 4C03 | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 reduced | x-ray diffraction | A, B | — | — |
| 4C04 | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with inhibitor | x-ray diffraction | A | — | — |
| 4C04 | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with inhibitor | x-ray diffraction | A | — | — |
| 4C05 | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with SAH | x-ray diffraction | A | — | — |
| 4C05 | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with sah | x-ray diffraction | A | — | — |
| 4C06 | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with MgCl2 | x-ray diffraction | A | — | — |
| 4C06 | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with MGCL2 | x-ray diffraction | A | — | — |
| 4C07 | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with CaCl2 at 1.5… | x-ray diffraction | A | — | — |
| 4C07 | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with CACL2 at 1.5… | x-ray diffraction | A | — | — |
| 4C08 | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with CaCl2 at 1.34… | x-ray diffraction | A | — | — |
| 4C08 | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with CACL2 at 1.34… | x-ray diffraction | A | — | — |
| 5FQN | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with SAH at 1.65 Angstroms | x-ray diffraction | A | — | — |
| 5FQN | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with sah at 1.65 ångströms | x-ray diffraction | A | — | — |
| 5FQO | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with SAH and magnesium | x-ray diffraction | A | SAH, MG | 2 (best 0.65) |
| 5FQO | Crystal structure of M. musculus protein arginine methyltransferase PRMT6 with sah and magnesium | x-ray diffraction | A | — | — |
| 5LV4 | Crystal structure of mouse PRMT6 in complex with inhibitor LH1236 | x-ray diffraction | A | 78K | 2 (best 0.64) |
| 5LV4 | Crystal structure of mouse PRMT6 in complex with inhibitor LH1236 | x-ray diffraction | A | 78K | — |
| 5LV5 | Crystal structure of mouse PRMT6 in complex with inhibitor LH1458 | x-ray diffraction | A | 78G | 2 (best 0.62) |
| 5LV5 | Crystal structure of mouse PRMT6 in complex with inhibitor LH1458 | x-ray diffraction | A | 78G | — |
| 6SQ3 | Crystal structure of mouse PRMT6 in complex with inhibitor U1 | x-ray diffraction | A, B | 6RE | 5 (best 0.73) |
| 6SQ3 | Crystal structure of mouse PRMT6 in complex with inhibitor U1 | x-ray diffraction | A, B | 6RE | — |
| 6SQ4 | Crystal structure of mouse PRMT6 in complex with inhibitor U2 | x-ray diffraction | A, B | IOD, GJV | 3 (best 0.79) |
| 6SQ4 | Crystal structure of mouse PRMT6 in complex with inhibitor U2 | x-ray diffraction | A, B | GJV | — |
| 6SQH | Crystal structure of mouse PRMT6 with partial C-terminal TEV cleavage site | x-ray diffraction | A, B | — | 6 (best 0.64) |
| 6SQH | Crystal structure of mouse PRMT6 with partial C-terminal tev cleavage site | x-ray diffraction | A, B | — | — |
| 6SQI | Crystal structure of mouse PRMT6 with C-terminal TEV cleavage site | x-ray diffraction | A | CA | 3 (best 0.56) |
| 6SQI | Crystal structure of mouse PRMT6 with C-terminal tev cleavage site | x-ray diffraction | A | CA | — |
| 6SQK | Crystal structure of mouse PRMT6 with modified H7-4 peptide | x-ray diffraction | A, B | — | 6 (best 0.55) |
| 6SQK | Crystal structure of mouse PRMT6 with modified H7-4 peptide | x-ray diffraction | A, B | — | — |
| 7NUD | Crystal structure of mouse PRMT6 in complex with inhibitor EML734 | x-ray diffraction | A, B | LRZ | 4 (best 0.75) |
| 7NUD | Crystal structure of mouse PRMT6 in complex with inhibitor EML734 | x-ray diffraction | A, B | LRZ | — |
| 7NUE | Crystal structure of mouse PRMT6 in complex with inhibitor EML736 | x-ray diffraction | A, B | LSK | — |
| 7NUE | Crystal structure of mouse PRMT6 in complex with inhibitor EML736 | x-ray diffraction | A, B | LSK | — |
| 7P2R | Crystal structure of mouse PRMT6 in complex with inhibitor EML980 | x-ray diffraction | A, B | 4R7, SAH | 4 (best 0.77) |
| 7P2R | Crystal structure of mouse PRMT6 in complex with inhibitor EML980 | x-ray diffraction | A, B | 4R7, SAH | 4 (best 0.77) |
| Q6NZB1 | AlphaFold monomer V2.0 prediction for protein arginine N-methyltransferase 6 (Q6NZB1) | predicted | A | — | — |
Ligands
- SAH · S-adenosyl-L-homocysteine · in 3 records
- 4R7 · methyl 6-[4-[[N-[2-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate · in 2 records
- 6RE · [[2-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3, 4-bis(oxidanyl)oxolan-2-yl]ethylamino]-azanyl-methylidene]azanium · in 2 records
- 78G · 2-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethyl-[[4-azanyl-1-(methoxymethyl)-2-oxidanylidene-pyrimidin-5-yl]methyl]-[(3~{S})-3-azanyl-4-oxidanyl-4-oxidanylidene-butyl]azanium · in 2 records
- 78K · (2~{R})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[[4-azanyl-1-(methoxymethyl)-2-oxidanylidene-pyrimidin-5-yl]methyl]amino]-2-azanyl-butanoic acid · in 2 records
- CA · Calcium ion · in 2 records
- GJV · 9-(7-{[amino(iminio)methyl]amino}-5,6,7-trideoxy-beta-D-ribo-heptofuranosyl)-9H-purin-6-amine · in 2 records
- LRZ · methyl 6-[3-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]propylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate · in 2 records
- LSK · methyl 6-[5-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]pentylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate · in 2 records
- IOD · Iodide ion · in 1 record
- MG · Magnesium ion · in 1 record
Experiment against prediction
- 6SQK chain B against the predicted model Q6NZB1: TM-score 1.00, RMSD 0.38 Å
- 6SQK chain B against the predicted model Q6NZB1: TM-score 1.00, RMSD 0.38 Å
- 6SQK chain A against the predicted model Q6NZB1: TM-score 1.00, RMSD 0.43 Å
- 6SQK chain A against the predicted model Q6NZB1: TM-score 1.00, RMSD 0.43 Å
- 5LV4 chain A against the predicted model Q6NZB1: TM-score 0.99, RMSD 0.47 Å
- 5LV4 chain A against the predicted model Q6NZB1: TM-score 0.99, RMSD 0.47 Å
- 4C03 chain B against the predicted model Q6NZB1: TM-score 0.99, RMSD 0.38 Å
- 4C03 chain B against the predicted model Q6NZB1: TM-score 0.99, RMSD 0.38 Å
- 5LV5 chain A against the predicted model Q6NZB1: TM-score 0.99, RMSD 0.54 Å
- 5LV5 chain A against the predicted model Q6NZB1: TM-score 0.99, RMSD 0.54 Å
Elsewhere
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