LSK · methyl 6-[5-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]pentylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate

Binding sites

LSK in 4 structures; the first of them:

• 7NUE · Crystal structure of mouse PRMT6 in complex with inhibitor EML736 · LSK A401 · binds TYR50, TYR54, HIS60, MET63, GLY93, GLY95, VAL114, GLU115 and 13 more
• 7PPQ · CARM1 in complex with EML736 · LSK A501 · binds PHE138, TYR150, PHE151, PHE153, TYR154, GLN160, MET163, GLY193 and 23 more
• 7NUE · Crystal structure of mouse PRMT6 in complex with inhibitor EML736 · LSK A401 · binds TYR50, TYR54, HIS60, MET63, GLY93, GLY95, VAL114, GLU115 and 13 more
• 7PPQ · CARM1 in complex with EML736 · LSK A501 · binds PHE138, TYR150, PHE151, PHE153, TYR154, MET163, GLY193, GLU215 and 17 more

Residues it binds most

GLU 12, GLY 12, TYR 12, MET 12, PHE 8, SER 12, VAL 12, LYS 8, PRO 12, ALA 12 (residue and the binding sites it lines).

Found with

• EDO · 1,2-ethanediol