LRZ · methyl 6-[3-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]propylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate

Binding sites

LRZ in 3 structures; the first of them:

• 7PV6 · CARM1 in complex with EML734 · LRZ A501 · binds PHE138, TYR150, PHE151, PHE153, TYR154, GLN159, GLN160, MET163 and 21 more
• 7NUD · Crystal structure of mouse PRMT6 in complex with inhibitor EML734 · LRZ A401 · binds ASP47, TYR50, TYR51, TYR54, HIS60, MET63, GLY93, GLY95 and 14 more
• 7PV6 · CARM1 in complex with EML734 · LRZ A501 · binds TYR150, PHE151, PHE153, TYR154, GLN159, GLN160, MET163, GLY193 and 16 more

Residues it binds most

GLU 10, GLY 10, MET 10, TYR 10, PHE 8, SER 10, VAL 10, GLN 8, LYS 8, ALA 10 (residue and the binding sites it lines).

Found with

• EDO · 1,2-ethanediol
• PG4 · Tetraethylene glycol