UniProt Q14832
Metabotropic glutamate receptor 3,Serine/threonine-protein kinase mTOR (Q14832)
Metabotropic glutamate receptor 3,Serine/threonine-protein kinase mTOR (UniProt Q14832), EC 2.7.11.1: 15 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 37 pockets. Binding sites, druggability and…
- UniProt
- Q14832
- Protein
- Metabotropic glutamate receptor 3,Serine/threonine-protein kinase mTOR
- EC
- 2.7.11.1
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 37 · 4 records with a druggable one
Structures
16 records of Q14832 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3SM9 | Crystal Structure of Metabotropic glutamate receptor 3 precursor in presence of LY341495 antagonist | x-ray diffraction | A | — | — |
| 3SM9 | Crystal structure of metabotropic glutamate receptor 3 precursor in presence of LY341495 antagonist | x-ray diffraction | A | — | — |
| 4XAR | mGluR2 ECD and mGluR3 ECD complex with ligands | x-ray diffraction | A | — | — |
| 4XAR | MGLUR2 ecd and MGLUR3 ecd complex with ligands | x-ray diffraction | A | — | — |
| 5CNK | MGLUR3 with glutamate | x-ray diffraction | A, B, C | — | — |
| 5CNM | mGluR3 complexed with glutamate analog | x-ray diffraction | A | 52Q, CL, SO4, MG | — |
| 5CNM | MGLUR3 complexed with glutamate analog | x-ray diffraction | A | — | — |
| 6B7H | Structure of MGLUR3 with an agonist | x-ray diffraction | A | NAG, CWY, CA | — |
| 7WI6 | Cryo-EM structure of LY341495/NAM-bound mGlu3 | electron microscopy | A, B | Z99, NAG | 16 (best 0.86) |
| 7WI6 | Cryo-EM structure of LY341495/NAM-bound MGLU3 | electron microscopy | A, B | Z99, NAG | — |
| 7WI8 | Cryo-EM structure of inactive MGLU3 bound to LY341495 | electron microscopy | A, B | NAG, Z99 | — |
| 7WIH | Cryo-EM structure of LY2794193-bound MGLU3 | electron microscopy | A, B | NAG, CWY | — |
| 8JCU | Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 (dimerization mode I) | electron microscopy | 3 | NAG, Z99 | 6 (best 0.83) |
| 8JCX | Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 and NAM563 (dimerization mode… | electron microscopy | 3 | NAG, Z99 | 7 (best 0.82) |
| 8JD1 | Cryo-EM structure of mGlu2-mGlu3 heterodimer in Rco state | electron microscopy | 3 | GLU, CLR | 8 (best 0.85) |
| Q14832 | AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 3 (Q14832) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 7 records
- Z99 · 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine · in 5 records
- CWY · (1S,2S,4S,5R,6S)-2-amino-4-[(3-methoxybenzene-1-carbonyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid · in 2 records
- 52Q · (1R,2S,4R,5R,6R)-2-amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid · in 1 record
- CA · Calcium ion · in 1 record
- CL · Chloride ion · in 1 record
- CLR · Cholesterol · in 1 record
- GLU · Glutamic acid · in 1 record
- MG · Magnesium ion · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 5CNK chain B against the predicted model Q14832: TM-score 0.98, RMSD 0.99 Å
- 5CNK chain C against the predicted model Q14832: TM-score 0.98, RMSD 1.09 Å
- 5CNK chain A against the predicted model Q14832: TM-score 0.98, RMSD 1.37 Å
- 4XAR chain A against the predicted model Q14832: TM-score 0.97, RMSD 1.48 Å
- 4XAR chain A against the predicted model Q14832: TM-score 0.97, RMSD 1.48 Å
- 6B7H chain A against the predicted model Q14832: TM-score 0.96, RMSD 1.48 Å
- 7WIH chain A against the predicted model Q14832: TM-score 0.91, RMSD 3.03 Å
- 7WIH chain B against the predicted model Q14832: TM-score 0.91, RMSD 3.03 Å
- 3SM9 chain A against the predicted model Q14832: TM-score 0.88, RMSD 2.73 Å
- 3SM9 chain A against the predicted model Q14832: TM-score 0.88, RMSD 2.73 Å
Elsewhere
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