UniProt Q04609
Glutamate carboxypeptidase 2 (Q04609)
Glutamate carboxypeptidase 2 (UniProt Q04609), EC 3.4.17.21: 155 experimental structures and 1 predicted model on GenesisL1, 22 ligands bound, 47 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q04609
- Protein
- Glutamate carboxypeptidase 2
- EC
- 3.4.17.21
- Experimental structures
- 155
- Predicted models
- 1
- Ligands
- 22
- Pockets
- 47 · 8 records with a druggable one
Structures
156 records of Q04609 in the MolNFT archive: 155 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1Z8L | Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase | x-ray diffraction | A, B, C, D | — | — |
| 1Z8L | Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase | x-ray diffraction | A, B, C, D | — | — |
| 2C6C | membrane-bound glutamate carboxypeptidase II (GCPII) in complex with GPI-18431… | x-ray diffraction | A | — | — |
| 2C6C | Membrane-bound glutamate carboxypeptidase II (gcpii) in complex with gpi-18431… | x-ray diffraction | A | — | — |
| 2C6G | Membrane-bound glutamate carboxypeptidase II (GCPII) with bound glutamate | x-ray diffraction | A | — | — |
| 2C6G | Membrane-bound glutamate carboxypeptidase II (gcpii) with bound glutamate | x-ray diffraction | A | — | — |
| 2C6P | Membrane-bound glutamate carboxypeptidase II (GCPII) in complex with phosphate anion | x-ray diffraction | A | — | — |
| 2C6P | Membrane-bound glutamate carboxypeptidase II (gcpii) in complex with phosphate anion | x-ray diffraction | A | — | — |
| 2CIJ | membrane-bound glutamate carboxypeptidase II (GCPII) with bound methionine | x-ray diffraction | A | — | — |
| 2CIJ | Membrane-bound glutamate carboxypeptidase II (gcpii) with bound methionine | x-ray diffraction | A | — | — |
| 2JBJ | membrane-bound glutamate carboxypeptidase II (GCPII) in complex with 2-PMPA… | x-ray diffraction | A | — | — |
| 2JBJ | Membrane-bound glutamate carboxypeptidase II (gcpii) in complex with 2-pmpa… | x-ray diffraction | A | — | — |
| 2JBK | membrane-bound glutamate carboxypeptidase II (GCPII) in complex with quisqualic acid (quisqualate… | x-ray diffraction | A | — | — |
| 2JBK | Membrane-bound glutamate carboxypeptidase II (gcpii) in complex with quisqualic acid (quisqualate… | x-ray diffraction | A | — | — |
| 2OOT | A High Resolution Structure of Ligand-free Human Glutamate Carboxypeptidase II | x-ray diffraction | A | — | — |
| 2OOT | A high resolution structure of ligand-free human glutamate carboxypeptidase II | x-ray diffraction | A | — | — |
| 2OR4 | A high resolution crystal structure of human glutamate carboxypeptidase II in complex with… | x-ray diffraction | A | — | — |
| 2OR4 | A high resolution crystal structure of human glutamate carboxypeptidase II in complex with… | x-ray diffraction | A | — | — |
| 2PVV | Structure of human glutamate carboxypeptidase II (GCPII) in complex with L-serine-O-sulfate | x-ray diffraction | A | — | — |
| 2PVV | Structure of human glutamate carboxypeptidase II (gcpii) in complex with L-serine-O-sulfate | x-ray diffraction | A | — | — |
| 2PVW | A high resolution structure of human glutamate carboxypeptidase II (GCPII) in complex with… | x-ray diffraction | A | — | — |
| 2PVW | A high resolution structure of human glutamate carboxypeptidase II (gcpii) in complex with… | x-ray diffraction | A | — | — |
| 2XEF | Human glutamate carboxypeptidase II in complex with Antibody- Recruiting Molecule ARM-P8 | x-ray diffraction | A | — | — |
| 2XEF | Human glutamate carboxypeptidase II in complex with antibody- recruiting molecule arm-P8 | x-ray diffraction | A | — | — |
| 2XEG | Human glutamate carboxypeptidase II in complex with Antibody- Recruiting Molecule ARM-P4 | x-ray diffraction | A | — | — |
| 2XEG | Human glutamate carboxypeptidase II in complex with antibody- recruiting molecule arm-P4 | x-ray diffraction | A | — | — |
| 2XEI | Human glutamate carboxypeptidase II in complex with Antibody- Recruiting Molecule ARM-P2 | x-ray diffraction | A | — | — |
| 2XEI | Human glutamate carboxypeptidase II in complex with antibody- recruiting molecule arm-P2 | x-ray diffraction | A | — | — |
| 2XEJ | Human glutamate carboxypeptidase II in complex with ARM-M4, urea- based inhibitor | x-ray diffraction | A | — | — |
| 2XEJ | Human glutamate carboxypeptidase II in complex with arm-M4, urea- based inhibitor | x-ray diffraction | A | — | — |
| 3BHX | X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a transition state… | x-ray diffraction | A | — | — |
| 3BHX | X-ray structure of human glutamate carboxypeptidase II (gcpii) in complex with a transition state… | x-ray diffraction | A | — | — |
| 3BI0 | X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a transition state… | x-ray diffraction | A | — | — |
| 3BI0 | X-ray structure of human glutamate carboxypeptidase II (gcpii) in complex with a transition state… | x-ray diffraction | A | — | — |
| 3BI1 | X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a transition state… | x-ray diffraction | A | — | — |
| 3BI1 | X-ray structure of human glutamate carboxypeptidase II (gcpii) in complex with a transition state… | x-ray diffraction | A | — | — |
| 3BXM | Structure of an inactive mutant of human glutamate carboxypeptidase II [GCPII(E424A)] in complex… | x-ray diffraction | A | — | — |
| 3BXM | Structure of an inactive mutant of human glutamate carboxypeptidase II [GCPII(E424A)] in complex… | x-ray diffraction | A | — | — |
| 3D7D | A high resolution crystal structure of human glutamate carboxypeptidase II (GCPII) in a complex… | x-ray diffraction | A | — | — |
| 3D7D | A high resolution crystal structure of human glutamate carboxypeptidase II (gcpii) in a complex… | x-ray diffraction | A | — | — |
| 3D7F | A high resolution crystal structure of human glutamate carboxypeptidase II (GCPII) in a complex… | x-ray diffraction | A | — | — |
| 3D7F | A high resolution crystal structure of human glutamate carboxypeptidase II (gcpii) in a complex… | x-ray diffraction | A | — | — |
| 3D7G | A high resolution crystal structure of human glutamate carboxypeptidase II (GCPII) in a complex… | x-ray diffraction | A | — | — |
| 3D7G | A high resolution crystal structure of human glutamate carboxypeptidase II (gcpii) in a complex… | x-ray diffraction | A | — | — |
| 3D7H | A high resolution crystal structure of human glutamate carboxypeptidase II (GCPII) in a complex… | x-ray diffraction | A | — | — |
| 3D7H | A high resolution crystal structure of human glutamate carboxypeptidase II (gcpii) in a complex… | x-ray diffraction | A | — | — |
| 3IWW | Crystal structure of human glutamate carboxypeptidase II (GCPII) in a complex with DBIBzL, a… | x-ray diffraction | A | — | — |
| 3IWW | Crystal structure of human glutamate carboxypeptidase II (gcpii) in a complex with dbibzl, a… | x-ray diffraction | A | — | — |
| 3RBU | N-terminally AviTEV-tagged Human Glutamate Carboxypeptidase II in complex with 2-PMPA | x-ray diffraction | A | — | — |
| 3RBU | N-terminally avitev-tagged human glutamate carboxypeptidase II in complex with 2-pmpa | x-ray diffraction | A | — | — |
| 3SJE | X-ray structure of human glutamate carboxypeptidase II (the E424A inactive mutant) in complex with… | x-ray diffraction | A | — | — |
| 3SJE | X-ray structure of human glutamate carboxypeptidase II (the E424A inactive mutant) in complex with… | x-ray diffraction | A | — | — |
| 3SJF | X-ray structure of human glutamate carboxypeptidase II in complex with a urea-based inhibitor (A25) | x-ray diffraction | A | — | — |
| 3SJF | X-ray structure of human glutamate carboxypeptidase II in complex with a urea-based inhibitor (A25) | x-ray diffraction | A | — | — |
| 3SJG | Human glutamate carboxypeptidase II (E424A inactive mutant ) in complex with… | x-ray diffraction | A | — | — |
| 3SJG | Human glutamate carboxypeptidase II (E424A inactive mutant ) in complex with… | x-ray diffraction | A | — | — |
| 3SJX | X-ray structure of human glutamate carboxypeptidase II (the E424A inactive mutant) in complex with… | x-ray diffraction | A | — | — |
| 3SJX | X-ray structure of human glutamate carboxypeptidase II (the E424A inactive mutant) in complex with… | x-ray diffraction | A | — | — |
| 4JYW | X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with CTT1057 | x-ray diffraction | A | — | — |
| 4JYW | X-ray structure of human glutamate carboxypeptidase II (gcpii) in complex with CTT1057 | x-ray diffraction | A | — | — |
96 records more on the page itself.
Ligands
- CA · Calcium ion · in 32 records
- CL · Chloride ion · in 32 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 32 records
- ZN · Zinc ion · in 32 records
- BMA · beta-D-mannopyranose · in 26 records
- MAN · alpha-D-mannopyranose · in 8 records
- FUC · alpha-L-fucopyranose · in 6 records
- NA · Sodium ion · in 4 records
- TAM · Tris(hydroxyethyl)aminomethane · in 3 records
- JX5 · (2~{S})-2-[[(2~{R})-2-[4-[(4-iodophenyl) carbonylamino]butanoylamino]-3-oxidanyl-3-oxidanylidene-propyl]carbamoylamino]pentanedioic acid · in 2 records
- TKZ · (((S)-1-carboxy-5-((E)-2-cyano-3-(5-(1-(3-methoxy-3-oxopropyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophen-2-yl)acrylamido)pentyl)carbamoyl)-L-glutamic acid · in 2 records
- 5PU · 4-[(2~{R})-2-carboxy-5-(oxidanylamino)-5-oxidanylidene-pentyl]benzoic acid · in 1 record
- 9OQ · (2~{S})-2-[[(2~{S})-6-[[(2~{S})-2-[[4-[[[(2~{R})-2-[[(2~{R})-2-[(6-fluoranylpyridin-3-yl)carbonylamino]-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]methyl]phenyl]carbonylamino]-3-naphthalen-2-yl-propanoyl]amino]-1-oxidanyl-1-oxidanylidene-hexan-2-yl]carbamoylamino]pentanedioic acid · in 1 record
- 9OT · (2~{S})-2-[[(2~{S})-6-[[(2~{S})-2-[[4-[[[(2~{S})-2-[[(2~{S})-2-[(6-fluoranylpyridin-3-yl)carbonylamino]-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]methyl]phenyl]carbonylamino]-3-naphthalen-2-yl-propanoyl]amino]-1-oxidanyl-1-oxidanylidene-hexan-2-yl]carbamoylamino]pentanedioic acid · in 1 record
- 9TB · (2~{S})-2-[[(2~{S})-6-[(4-fluorophenyl)methylamino]-1-oxidanyl-1,6-bis(oxidanylidene)hexan-2-yl]carbamoylamino]pentanedioic acid · in 1 record
- BXK · (2~{S})-2-[[(2~{R})-4-methyl-1-oxidanyl-1-oxidanylidene-pentan-2-yl]carbamoyloxy]pentanedioic acid · in 1 record
- CQB · (2~{S})-2-[[(2~{S})-4-methyl-1-oxidanyl-1-oxidanylidene-pentan-2-yl]carbamoyloxy]pentanedioic acid · in 1 record
- G88 · (2S)-2-(phosphonomethyl)pentanedioic acid · in 1 record
- KRZ · (2~{S})-2-[[(3~{S})-3-[3-[(4-iodophenyl) carbonylamino]propanoylamino]-4-oxidanyl-4-oxidanylidene-butyl]carbamoylamino]pentanedioic acid · in 1 record
- LHK · (2~{S})-2-[[(2~{S})-1,4-bis(oxidanyl)-1,4-bis(oxidanylidene)butan-2-yl]sulfamoylamino]pentanedioic acid · in 1 record
- QWF · (2~{S})-2-[[(2~{S})-1-oxidanyl-1-oxidanylidene-6-[[(~{E},2~{S})-5-phenyl-2-[[4-[[2-[4,7,10-tris(2-hydroxy-2-oxoethyl)-1,4,7,10-tetrazacyclododec-1-yl]ethanoylamino]methyl]cyclohexyl]carbonylamino]pent-4-enoyl]amino]hexan-2-yl]carbamoylamino]pentanedioic acid · in 1 record
- QYF · (2~{S})-2-[[(2~{S})-6-[[(2~{S})-3-naphthalen-2-yl-2-[[4-[[2-[(11~{Z})-4,7,10-tris(2-hydroxy-2-oxoethyl)-1,4,7,10-tetrazacyclododec-11-en-1-yl]ethanoylamino]methyl]cyclohexyl]carbonylamino]propanoyl]amino]-1-oxidanyl-1-oxidanylidene-hexan-2-yl]carbamoylamino]pentanedioic acid · in 1 record
Experiment against prediction
- 8BOL chain A against the predicted model Q04609: TM-score 1.00, RMSD 0.51 Å
- 4X3R chain A against the predicted model Q04609: TM-score 1.00, RMSD 0.53 Å
- 4X3R chain A against the predicted model Q04609: TM-score 1.00, RMSD 0.53 Å
- 5D29 chain A against the predicted model Q04609: TM-score 1.00, RMSD 0.52 Å
- 4NGR chain A against the predicted model Q04609: TM-score 1.00, RMSD 0.54 Å
- 4NGR chain A against the predicted model Q04609: TM-score 1.00, RMSD 0.54 Å
- 2C6C chain A against the predicted model Q04609: TM-score 1.00, RMSD 0.52 Å
- 2C6C chain A against the predicted model Q04609: TM-score 1.00, RMSD 0.52 Å
- 4NGQ chain A against the predicted model Q04609: TM-score 1.00, RMSD 0.55 Å
- 4NGQ chain A against the predicted model Q04609: TM-score 1.00, RMSD 0.55 Å
Elsewhere
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