UniProt Q01080
DNA-directed RNA polymerase I subunit RPA49 (Q01080)
DNA-directed RNA polymerase I subunit RPA49 (UniProt Q01080): 49 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q01080
- Protein
- DNA-directed RNA polymerase I subunit RPA49
- Experimental structures
- 49
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 8 · 2 records with a druggable one
Structures
50 records of Q01080 in the MolNFT archive: 49 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3NFH | Crystal structure of tandem winged helix domain of RNA polymerase I subunit A49 (P4) | x-ray diffraction | A, B | — | — |
| 3NFH | Crystal structure of tandem winged helix domain of RNA polymerase I subunit A49 (P4) | x-ray diffraction | A, B | — | — |
| 3NFI | Crystal structure of tandem winged helix domain of RNA polymerase I subunit A49 | x-ray diffraction | A, B, C, D, E | — | — |
| 3NFI | Crystal structure of tandem winged helix domain of RNA polymerase I subunit A49 | x-ray diffraction | A, B, C, D, E | — | — |
| 4C2M | Structure of RNA polymerase I at 2.8 A resolution | x-ray diffraction | 2, M | — | — |
| 4C2M | Structure of RNA polymerase I at 2.8 a resolution | x-ray diffraction | 2, M | — | — |
| 4C3H | Structure of 14-subunit RNA polymerase I at 3.27 A resolution, crystal form C2-93 | x-ray diffraction | M | — | — |
| 4C3H | Structure of 14-subunit RNA polymerase I at 3.27 a resolution, crystal form C2-93 | x-ray diffraction | M | — | — |
| 4C3I | Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100 | x-ray diffraction | M | — | — |
| 4C3I | Structure of 14-subunit RNA polymerase I at 3.0 a resolution, crystal form C2-100 | x-ray diffraction | M | — | — |
| 4C3J | Structure of 14-subunit RNA polymerase I at 3.35 A resolution, crystal form C2-90 | x-ray diffraction | M | — | — |
| 4C3J | Structure of 14-subunit RNA polymerase I at 3.35 a resolution, crystal form C2-90 | x-ray diffraction | M | — | — |
| 5G5L | RNA polymerase I-RRN3 complex at 4.8 a resolution | electron microscopy | M | — | — |
| 5LMX | Monomeric RNA polymerase I at 4.9 a resolution | electron microscopy | M | — | — |
| 5M3F | Yeast RNA polymerase I elongation complex at 3.8A | electron microscopy | M | — | — |
| 5M3M | Free monomeric RNA polymerase I at 4.0A resolution | electron microscopy | M | — | — |
| 5M3M | Free monomeric RNA polymerase I at 4.0A resolution | electron microscopy | M | — | — |
| 5M5W | RNA polymerase I open complex | electron microscopy | M | ZN | — |
| 5M5X | RNA Polymerase I elongation complex 1 | electron microscopy | M | — | — |
| 5M5X | RNA polymerase I elongation complex 1 | electron microscopy | M | — | — |
| 5M5Y | RNA polymerase I elongation complex 2 | electron microscopy | M | — | — |
| 5M64 | RNA polymerase I elongation complex with A49 tandem winged helix domain | electron microscopy | M | ZN | — |
| 5N5Y | Cryo-EM structure of RNA polymerase I in complex with RRN3 and core factor (orientation III) | electron microscopy | M | — | — |
| 5N5Z | Cryo-EM structure of RNA polymerase I in complex with Rrn3 and Core Factor (Orientation II) | electron microscopy | M | — | 2 (best 0.75) |
| 5N5Z | Cryo-EM structure of RNA polymerase I in complex with RRN3 and core factor (orientation II) | electron microscopy | M | — | — |
| 5N60 | Cryo-EM structure of RNA polymerase I in complex with RRN3 and core factor (orientation I) | electron microscopy | M | — | — |
| 5N61 | RNA polymerase I initially transcribing complex | electron microscopy | M | — | — |
| 5OA1 | RNA polymerase I pre-initiation complex | electron microscopy | M | — | — |
| 5W5Y | RNA polymerase I initial transcribing complex | electron microscopy | M | — | — |
| 5W64 | RNA polymerase I initial transcribing complex state 1 | electron microscopy | M | — | — |
| 5W65 | RNA polymerase I initial transcribing complex state 2 | electron microscopy | M | — | — |
| 5W66 | RNA polymerase I initial transcribing complex state 3 | electron microscopy | M | — | — |
| 6H67 | Yeast RNA polymerase I elongation complex stalled by cyclobutane pyrimidine dimer (CPD) | electron microscopy | M | — | — |
| 6H67 | Yeast RNA polymerase I elongation complex stalled by cyclobutane pyrimidine dimer (cpd) | electron microscopy | M | — | — |
| 6H68 | Yeast RNA polymerase I elongation complex stalled by cyclobutane pyrimidine dimer (CPD) with… | electron microscopy | M | — | — |
| 6H68 | Yeast RNA polymerase I elongation complex stalled by cyclobutane pyrimidine dimer (cpd) with… | electron microscopy | M | — | — |
| 6HKO | Yeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPP | electron microscopy | M | — | — |
| 6HKO | Yeast RNA polymerase I elongation complex bound to nucleotide analog gmpcpp | electron microscopy | M | — | — |
| 6RQH | RNA Polymerase I Closed Conformation 1 (CC1) | electron microscopy | M | — | — |
| 6RQH | RNA polymerase I closed conformation 1 (CC1) | electron microscopy | M | — | — |
| 6RQL | RNA polymerase I closed conformation 2 (CC2) | electron microscopy | M | — | — |
| 6RQT | RNA Polymerase I-tWH-Rrn3-DNA | electron microscopy | M | — | — |
| 6RQT | RNA polymerase I-twh-RRN3-DNA | electron microscopy | M | — | — |
| 6RRD | RNA polymerase I pre-initiation complex DNA opening intermediate 1 | electron microscopy | M | — | — |
| 6RUI | RNA polymerase I pre-initiation complex DNA opening intermediate 2 | electron microscopy | M | — | — |
| 6RUO | RNA Polymerase I Open Complex conformation 1 | electron microscopy | M | — | 1 (best 0.80) |
| 6RUO | RNA polymerase I open complex conformation 1 | electron microscopy | M | — | — |
| 6RWE | RNA polymerase I open complex conformation 2 | electron microscopy | M | — | — |
| 6TPS | Early intermediate RNA polymerase I pre-initiation complex - eipic | electron microscopy | M | — | — |
| Q01080 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase I subunit RPA49 (Q01080) | predicted | A | — | 5 (best 0.41) |
Ligands
- ZN · Zinc ion · in 2 records
Experiment against prediction
- 3NFI chain E against the predicted model Q01080: TM-score 0.98, RMSD 0.97 Å
- 3NFI chain E against the predicted model Q01080: TM-score 0.98, RMSD 0.97 Å
- 3NFI chain C against the predicted model Q01080: TM-score 0.98, RMSD 0.94 Å
- 3NFI chain C against the predicted model Q01080: TM-score 0.98, RMSD 0.94 Å
- 3NFH chain A against the predicted model Q01080: TM-score 0.98, RMSD 0.84 Å
- 3NFH chain A against the predicted model Q01080: TM-score 0.98, RMSD 0.84 Å
- 3NFH chain B against the predicted model Q01080: TM-score 0.97, RMSD 1.14 Å
- 3NFH chain B against the predicted model Q01080: TM-score 0.97, RMSD 1.14 Å
- 3NFI chain A against the predicted model Q01080: TM-score 0.96, RMSD 1.30 Å
- 3NFI chain A against the predicted model Q01080: TM-score 0.96, RMSD 1.30 Å
Elsewhere
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