MolNFT v1 · #384858 · protein
AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase I subunit RPA49 (Q01080)
Q01080: “AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase I subunit RPA49 (Q01080)”. 5 pockets (best druggability 0.41). MolNFT v1 #384858 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q01080
- Type
- protein
- Length
- 415 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xdCa3E8477B678EB93Ed98933F2784Ed8bf41Dae5
- Molecule
- DNA-directed RNA polymerase I subunit RPA49
- UniProt
- Q01080
- Pockets
- 5 · best druggability 0.41
Structure
1 distinct chain · 40% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-directed RNA polymerase I subunit RPA49 | protein | 415 | 40% helix, 15% strand | Q01080 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 97 | 0.41 | 0.77 | 14 | empty |
| 2 | 52 | 0.39 | 0.81 | 13 | empty |
| 3 | 60 | 0.38 | 0.80 | 12 | empty |
| 4 | 85 | 0.32 | 0.73 | 18 | empty |
| 5 | 56 | 0.32 | 0.76 | 13 | empty |
Compared structures
- 5W66 · RNA polymerase I initial transcribing complex state 3 · an experimental structure of the same protein · chain A against M, TM-score 0.54
- 6H68 · Yeast RNA polymerase I elongation complex stalled by cyclobutane pyrimidine dimer (cpd)… · an experimental structure of the same protein · chain A against M, TM-score 0.54
- 6H68 · Yeast RNA polymerase I elongation complex stalled by cyclobutane pyrimidine dimer (CPD)… · an experimental structure of the same protein · chain A against M, TM-score 0.54
- 6RQT · RNA Polymerase I-tWH-Rrn3-DNA · an experimental structure of the same protein · chain A against M, TM-score 0.53
- 6RQT · RNA polymerase I-twh-RRN3-DNA · an experimental structure of the same protein · chain A against M, TM-score 0.53
- 3NFI · Crystal structure of tandem winged helix domain of RNA polymerase I subunit A49 · an experimental structure of the same protein · chain A against A, TM-score 0.51
- 3NFI · Crystal structure of tandem winged helix domain of RNA polymerase I subunit A49 · an experimental structure of the same protein · chain A against A, TM-score 0.51
- 5M64 · RNA polymerase I elongation complex with A49 tandem winged helix domain · an experimental structure of the same protein · chain A against M, TM-score 0.51
- 3NFH · Crystal structure of tandem winged helix domain of RNA polymerase I subunit A49 (P4) · an experimental structure of the same protein · chain A against B, TM-score 0.51
- 3NFH · Crystal structure of tandem winged helix domain of RNA polymerase I subunit A49 (P4) · an experimental structure of the same protein · chain A against B, TM-score 0.51
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q01080
- Elsewhere: UniProt Q01080 · AlphaFold DB Q01080
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