UniProt P63104
14-3-3 protein zeta/delta (P63104)
14-3-3 protein zeta/delta (UniProt P63104): 114 experimental structures and 1 predicted model on GenesisL1, 17 ligands bound, 199 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P63104
- Protein
- 14-3-3 protein zeta/delta
- Experimental structures
- 114
- Predicted models
- 1
- Ligands
- 17
- Pockets
- 199 · 35 records with a druggable one
Structures
115 records of P63104 in the MolNFT archive: 114 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1IB1 | Crystal structure of the 14-3-3 ZETA:SEROTONIN N-acetyltransferase complex | x-ray diffraction | A, B, C, D | — | — |
| 1IB1 | Crystal structure of the 14-3-3 ZETA:SEROTONIN N-acetyltransferase complex | x-ray diffraction | A, B, C, D | — | — |
| 2C1J | Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3 | x-ray diffraction | A, B | — | — |
| 2C1J | Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3 | x-ray diffraction | A, B | — | — |
| 2C1N | Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3 | x-ray diffraction | A, B | — | — |
| 2C1N | Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3 | x-ray diffraction | A, B | — | — |
| 2O02 | Phosphorylation independent interactions between 14-3-3 and Exoenzyme S: from structure to… | x-ray diffraction | A, B | — | — |
| 2O02 | Phosphorylation independent interactions between 14-3-3 and exoenzyme S: from structure to… | x-ray diffraction | A, B | — | — |
| 2WH0 | Recognition of an intrachain tandem 14-3-3 binding site within protein kinase C epsilon | x-ray diffraction | A, B, C, D | — | — |
| 2WH0 | Recognition of an intrachain tandem 14-3-3 binding site within protein kinase C epsilon | x-ray diffraction | A, B, C, D | — | — |
| 3CU8 | Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome | x-ray diffraction | A, B | — | — |
| 3CU8 | Impaired binding of 14-3-3 to RAF1 is linked to noonan and leopard syndrome | x-ray diffraction | A, B | — | — |
| 3NKX | Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome | x-ray diffraction | A, B | — | — |
| 3NKX | Impaired binding of 14-3-3 to RAF1 is linked to noonan and leopard syndrome | x-ray diffraction | A, B | — | — |
| 3RDH | X-ray induced covalent inhibition of 14-3-3 | x-ray diffraction | A, B, C, D | — | — |
| 3RDH | X-ray induced covalent inhibition of 14-3-3 | x-ray diffraction | A, B, C, D | — | — |
| 4BG6 | 14-3-3 interaction with Rnd3 prenyl-phosphorylation motif | x-ray diffraction | A, B | — | — |
| 4BG6 | 14-3-3 interaction with RND3 prenyl-phosphorylation motif | x-ray diffraction | A, B | — | — |
| 4FJ3 | 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide | x-ray diffraction | A, B | — | — |
| 4FJ3 | 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide | x-ray diffraction | A, B | — | — |
| 4HKC | 14-3-3-zeta in complex with S1011 phosphorylated integrin alpha-4 peptide | x-ray diffraction | A | — | — |
| 4HKC | 14-3-3-zeta in complex with S1011 phosphorylated integrin alpha-4 peptide | x-ray diffraction | A | — | — |
| 4IHL | Human 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A | x-ray diffraction | A, B | — | — |
| 4IHL | Human 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and cotylenin a | x-ray diffraction | A, B | — | — |
| 4N7G | Crystal structure of 14-3-3zeta in complex with a peptide derived from ExoS | x-ray diffraction | A | — | — |
| 4N7G | Crystal structure of 14-3-3ZETA in complex with a peptide derived from exos | x-ray diffraction | A | — | — |
| 4N7Y | Crystal structure of 14-3-3zeta in complex with a 8-carbon-linker cyclic peptide derived from ExoS | x-ray diffraction | A, B | — | — |
| 4N7Y | Crystal structure of 14-3-3ZETA in complex with a 8-carbon-linker cyclic peptide derived from exos | x-ray diffraction | A, B | — | — |
| 4N84 | Crystal structure of 14-3-3zeta in complex with a 12-carbon-linker cyclic peptide derived from ExoS | x-ray diffraction | A, B | — | — |
| 4N84 | Crystal structure of 14-3-3ZETA in complex with a 12-carbon-linker cyclic peptide derived from exos | x-ray diffraction | A, B | — | — |
| 4WRQ | Crystal Structure of 14-3-3 zeta with Chibby peptide | x-ray diffraction | A, B | — | — |
| 4WRQ | Crystal structure of 14-3-3 zeta with chibby peptide | x-ray diffraction | A, B | — | — |
| 4ZDR | Crystal structure of 14-3-3[zeta]-LKB1 fusion protein | x-ray diffraction | A, B | — | — |
| 4ZDR | Crystal structure of 14-3-3[ZETA]-LKB1 fusion protein | x-ray diffraction | A, B | — | — |
| 5D2D | Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 | x-ray diffraction | A, B | GLC, FRU, CL | — |
| 5D2D | Crystal structure of human 14-3-3 zeta in complex with cftr R-domain peptide PS753-PS768 | x-ray diffraction | A, B | — | — |
| 5D3F | Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 and… | x-ray diffraction | A, B | FSC | 6 (best 0.65) |
| 5D3F | Crystal structure of human 14-3-3 zeta in complex with cftr R-domain peptide PS753-PS768 and… | x-ray diffraction | A, B | — | — |
| 5EWZ | Small-molecule stabilization of the 14-3-3/Gab2 PPI interface | x-ray diffraction | A, B | BEZ | 4 (best 0.57) |
| 5EWZ | Small-molecule stabilization of the 14-3-3/GAB2 ppi interface | x-ray diffraction | A, B | — | — |
| 5EXA | Small-molecule stabilization of the 14-3-3/Gab2 PPI interface | x-ray diffraction | A, B | 5SO, BEZ, MG | — |
| 5EXA | Small-molecule stabilization of the 14-3-3/GAB2 ppi interface | x-ray diffraction | A, B | — | — |
| 5J31 | Crystal structure of 14-3-3zeta in complex with an alkyne cross-linked cyclic peptide derived from… | x-ray diffraction | A, B | BEZ | 1 (best 0.53) |
| 5J31 | Crystal structure of 14-3-3ZETA in complex with an alkyne cross-linked cyclic peptide derived from… | x-ray diffraction | A, B | — | — |
| 5JM4 | Crystal structure of 14-3-3zeta in complex with a cyclic peptide involving an adamantyl and a… | x-ray diffraction | A, B | BEZ | — |
| 5JM4 | Crystal structure of 14-3-3ZETA in complex with a cyclic peptide involving an adamantyl and a… | x-ray diffraction | A, B | — | — |
| 5M35 | The molecular tweezer CLR01 stabilizes a disordered protein-protein interface | x-ray diffraction | A, B | BEZ | 5 (best 0.64) |
| 5M35 | The molecular tweezer CLR01 stabilizes a disordered protein-protein interface | x-ray diffraction | A, B | BEZ | — |
| 5M36 | The molecular tweezer CLR01 stabilizes a disordered protein-protein interface | x-ray diffraction | A, B | 9SZ, BEZ | — |
| 5M36 | The molecular tweezer CLR01 stabilizes a disordered protein-protein interface | x-ray diffraction | A, B | 9SZ, BEZ | — |
| 5M37 | The molecular tweezer CLR01 stabilizes a disordered protein-protein interface | x-ray diffraction | A, B | 9SZ, BEZ | — |
| 5M37 | The molecular tweezer CLR01 stabilizes a disordered protein-protein interface | x-ray diffraction | A, B | 9SZ, BEZ | — |
| 5NAS | Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide | x-ray diffraction | A, B | — | 3 (best 0.55) |
| 5NAS | Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide | x-ray diffraction | A, B | — | — |
| 5ULO | Crystal Structure of 14-3-3 zeta in Complex with a Serine 124-phosphorylated TBC1D7 peptide | x-ray diffraction | A, B | UNX | 4 (best 0.59) |
| 5ULO | Crystal structure of 14-3-3 zeta in complex with a serine 124- phosphorylated TBC1D7 peptide | x-ray diffraction | A, B | UNX | — |
| 5WXN | Structure of the LKB1 and 14-3-3 complex | x-ray diffraction | A, B | — | 3 (best 0.52) |
| 5WXN | Structure of the LKB1 and 14-3-3 complex | x-ray diffraction | A, B | — | — |
| 5XY9 | Structure of the MST4 and 14-3-3 complex | x-ray diffraction | A, B | — | 6 (best 0.60) |
| 5XY9 | Structure of the MST4 and 14-3-3 complex | x-ray diffraction | A, B | — | — |
55 records more on the page itself.
Ligands
- BEZ · Benzoic acid · in 19 records
- CL · Chloride ion · in 7 records
- CA · Calcium ion · in 6 records
- 9SZ · C42 H32 O8 P2 · in 4 records
- FSC · Fusicoccin · in 3 records
- DW8 · [2-[2-oxidanylidene-2-[[3-[2-[2-[2-[3-oxidanylidene-3-(propylamino) propoxy]ethoxy]ethoxy]ethylcarbamoyl]phenyl]amino]etho xy]phenyl]phosphonic acid · in 2 records
- DWE · [2-[2-oxidanylidene-2-[[3-[2-[2-[2-[3-oxidanylidene-3-[2-[3-[2-[2-[2-[[4-[2-(2-phosphonophenoxy) ethanoylamino]phenyl]carbonylamino]ethoxy]ethoxy]ethox y]propanoylamino]ethylamino]propoxy]ethoxy]ethoxy]ethy lcarbamoyl]phenyl]amino]ethoxy]phenyl]phosphonic acid · in 2 records
- DWK · [2-[2-oxidanylidene-2-[[3-[3-[2-[2-[3-[[4-[2-(2-phosphonophenoxy) ethanoylamino]phenyl]carbonylamino]propoxy]ethoxy]etho xy]propylcarbamoyl]phenyl]amino]ethoxy]phenyl]phosphon ic acid · in 2 records
- DWQ · [2-[2-oxidanylidene-2-[[3-[2-[5-[3-oxidanylidene-3-[3-[2-[2-[3-[3-[2-[2-[2-[[3-[2-(2-phosphonophenoxy) ethanoylamino]phenyl]carbonylamino]ethoxy]ethoxy]ethox y]propanoylamino]propoxy]ethoxy]ethoxy]propylamino]pro poxy]pentoxy]ethylcarbamoyl]phenyl]amino]ethoxy]phenyl ]phosphonic acid · in 2 records
- SAL · 2-hydroxybenzoic acid · in 2 records
- SO4 · Sulfate ion · in 2 records
- UNX · Unknown atom or ion · in 2 records
- 5SO · Fusicoccin A-THF derivative · in 1 record
- FRU · beta-D-fructofuranose · in 1 record
- GLC · alpha-D-glucopyranose · in 1 record
- MG · Magnesium ion · in 1 record
- QJK · 5-[(2~{R})-3-(4-chlorophenyl)carbonyl-2-(4-nitrophenyl)-4-oxidanyl-5-oxidanylidene-2~{H}-pyrrol-1-yl]-2-oxidanyl-benzoic acid · in 1 record
Experiment against prediction
- 6EJL chain A against the predicted model P63104: TM-score 0.99, RMSD 0.42 Å
- 6EJL chain A against the predicted model P63104: TM-score 0.99, RMSD 0.42 Å
- 4FJ3 chain B against the predicted model P63104: TM-score 0.99, RMSD 0.43 Å
- 4FJ3 chain B against the predicted model P63104: TM-score 0.99, RMSD 0.43 Å
- 7D8P chain A against the predicted model P63104: TM-score 0.99, RMSD 0.46 Å
- 7D8P chain A against the predicted model P63104: TM-score 0.99, RMSD 0.46 Å
- 6FNA chain B against the predicted model P63104: TM-score 0.99, RMSD 0.49 Å
- 6FNA chain B against the predicted model P63104: TM-score 0.99, RMSD 0.49 Å
- 8WE2 chain B against the predicted model P63104: TM-score 0.99, RMSD 0.50 Å
- 4FJ3 chain A against the predicted model P63104: TM-score 0.99, RMSD 0.50 Å
Elsewhere
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