UniProt P53582
Methionine aminopeptidase 1 (P53582)
Methionine aminopeptidase 1 (UniProt P53582), EC 3.4.11.18: 70 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P53582
- Protein
- Methionine aminopeptidase 1
- EC
- 3.4.11.18
- Experimental structures
- 70
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 3 · 2 records with a druggable one
Structures
71 records of P53582 in the MolNFT archive: 70 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2B3H | Crystal structure of Human Methionine Aminopeptidase Type I with a third cobalt in the active site | x-ray diffraction | A | — | — |
| 2B3H | Crystal structure of human methionine aminopeptidase type I with a third cobalt in the active site | x-ray diffraction | A | — | — |
| 2B3K | Crystal structure of Human Methionine Aminopeptidase Type I in the holo form | x-ray diffraction | A | — | — |
| 2B3K | Crystal structure of human methionine aminopeptidase type I in the holo form | x-ray diffraction | A | — | — |
| 2B3L | Crystal structure of type I human methionine aminopeptidase in the apo form | x-ray diffraction | A | — | — |
| 2B3L | Crystal structure of type I human methionine aminopeptidase in the apo form | x-ray diffraction | A | — | — |
| 2G6P | Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with… | x-ray diffraction | A | — | — |
| 2G6P | Crystal structure of truncated (delta 1-89) human methionine aminopeptidase type 1 in complex with… | x-ray diffraction | A | — | — |
| 2GZ5 | Human Type 1 methionine aminopeptidase in complex with ovalicin at 1.1 Ang | x-ray diffraction | A | — | — |
| 2GZ5 | Human type 1 methionine aminopeptidase in complex with ovalicin at 1.1 ang | x-ray diffraction | A | — | — |
| 2NQ6 | Crystal structure of human methionine aminopeptidase type 1 in complex with… | x-ray diffraction | A | — | — |
| 2NQ6 | Crystal structure of human methionine aminopeptidase type 1 in complex with… | x-ray diffraction | A | — | — |
| 2NQ7 | Crystal structure of type 1 human methionine aminopeptidase in complex with… | x-ray diffraction | A | — | — |
| 2NQ7 | Crystal structure of type 1 human methionine aminopeptidase in complex with… | x-ray diffraction | A | — | — |
| 4FLI | Human MetAP1 with bengamide analog Y16, in Mn form | x-ray diffraction | A | — | — |
| 4FLI | Human METAP1 with bengamide analog Y16, in mn form | x-ray diffraction | A | — | — |
| 4FLJ | Human MetAP1 with bengamide analog Y08, in Mn form | x-ray diffraction | A | — | — |
| 4FLJ | Human METAP1 with bengamide analog Y08, in mn form | x-ray diffraction | A | — | — |
| 4FLK | Human MetAP1 with bengamide analog Y10, in Mn form | x-ray diffraction | A | — | — |
| 4FLK | Human METAP1 with bengamide analog Y10, in mn form | x-ray diffraction | A | — | — |
| 4FLL | Human MetAP1 with bengamide analog YZ6, in Mn form | x-ray diffraction | A | — | — |
| 4FLL | Human METAP1 with bengamide analog YZ6, in mn form | x-ray diffraction | A | — | — |
| 4HXX | Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1 | x-ray diffraction | A | — | — |
| 4HXX | Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1 | x-ray diffraction | A | — | — |
| 4IKR | Crystal structure of Type 1 human methionine aminopeptidase in complex with… | x-ray diffraction | A | — | — |
| 4IKR | Crystal structure of type 1 human methionine aminopeptidase in complex with… | x-ray diffraction | A | — | — |
| 4IKS | Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with… | x-ray diffraction | A | — | — |
| 4IKS | Crystal structure of truncated (delta 1-89) human methionine aminopeptidase type 1 in complex with… | x-ray diffraction | A | — | — |
| 4IKT | Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with… | x-ray diffraction | A | — | — |
| 4IKT | Crystal structure of truncated (delta 1-89) human methionine aminopeptidase type 1 in complex with… | x-ray diffraction | A | — | — |
| 4IKU | Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with… | x-ray diffraction | A | — | — |
| 4IKU | Crystal structure of truncated (delta 1-89) human methionine aminopeptidase type 1 in complex with… | x-ray diffraction | A | — | — |
| 4IU6 | Human Methionine Aminopeptidase in complex with FZ1: Pyridinylquinazolines Selectively Inhibit… | x-ray diffraction | A | — | — |
| 4IU6 | Human methionine aminopeptidase in complex with FZ1: pyridinylquinazolines selectively inhibit… | x-ray diffraction | A | — | — |
| 4U1B | HsMetAP in complex with (1-amino-2-propylpentyl)phosphonic acid | x-ray diffraction | A | — | — |
| 4U1B | Hsmetap in complex with (1-amino-2-PROPYLPENTYL)PHOSPHONIC acid | x-ray diffraction | A | — | — |
| 4U69 | HsMetAP complex with (1-amino-2-methylpentyl)phosphonic acid | x-ray diffraction | A | — | — |
| 4U69 | Hsmetap complex with (1-amino-2-METHYLPENTYL)PHOSPHONIC acid | x-ray diffraction | A | — | — |
| 4U6C | HsMetAP in complex with [(1R)-1-amino-3-cyclopentylpropyl]phosphonic acid | x-ray diffraction | A | — | — |
| 4U6C | Hsmetap in complex with [(1R)-1-amino-3-CYCLOPENTYLPROPYL]PHOSPHONIC acid | x-ray diffraction | A | — | — |
| 4U6E | HsMetAP in complex with (amino(phenyl)methyl)phosphonic acid | x-ray diffraction | A | — | — |
| 4U6E | Hsmetap in complex with (AMINO(PHENYL)METHYL)PHOSPHONIC acid | x-ray diffraction | A | — | — |
| 4U6J | HsMetAP in complex with methionine | x-ray diffraction | A | — | — |
| 4U6J | Hsmetap in complex with methionine | x-ray diffraction | A | — | — |
| 4U6W | HsMetAP (F220M) in complex with 1-amino-2-propylpentyl]phosphonic acid | x-ray diffraction | A | — | — |
| 4U6W | Hsmetap (F220M) in complex with 1-amino-2-PROPYLPENTYL]PHOSPHONIC acid | x-ray diffraction | A | — | — |
| 4U6Z | HsMetAP(F309M) in complex with 1-amino-2-propylpentyl)phosphonic acid | x-ray diffraction | A | — | — |
| 4U6Z | HSMETAP(F309M) in complex with 1-amino-2-PROPYLPENTYL)PHOSPHONIC acid | x-ray diffraction | A | — | — |
| 4U70 | HsMetAP (F309M) in complex with (1-amino-2-cyclohexylethyl)phosphonic acid | x-ray diffraction | A | — | — |
| 4U70 | Hsmetap (F309M) in complex with (1-amino-2-CYCLOHEXYLETHYL)PHOSPHONIC acid | x-ray diffraction | A | — | — |
| 4U71 | HsMetAP(F309M) IN COMPLEX WITH 1- amino(cyclohexyl)methy)phosphonic acid | x-ray diffraction | A | — | — |
| 4U71 | HSMETAP(F309M) in complex with 1- AMINO(CYCLOHEXYL)METHY)PHOSPHONIC acid | x-ray diffraction | A | — | — |
| 4U73 | HsMetAP(F309M) IN COMPLEX WITH (amino(phenyl)methyl)phosphonic acid | x-ray diffraction | A | — | — |
| 4U73 | HSMETAP(F309M) in complex with (AMINO(PHENYL)METHYL)PHOSPHONIC acid | x-ray diffraction | A | — | — |
| 4U75 | HsMetAP (F309M) in complex with Methionine | x-ray diffraction | A | — | — |
| 4U75 | Hsmetap (F309M) in complex with methionine | x-ray diffraction | A | — | — |
| 4U76 | HsMetAP (F309M) holo form | x-ray diffraction | A | — | — |
| 4U76 | Hsmetap (F309M) holo form | x-ray diffraction | A | — | — |
| 5YKP | Human methionine aminopeptidase type 1b (F309M mutant) in complex with ovalicin | x-ray diffraction | A | CO, K, OVA | — |
| 5YKP | Human methionine aminopeptidase type 1B (F309M mutant) in complex with ovalicin | x-ray diffraction | A | CO, K, OVA | — |
11 records more on the page itself.
Ligands
- CO · Cobalt (II) ion · in 10 records
- NA · Sodium ion · in 7 records
- K · Potassium ion · in 3 records
- MG · Magnesium ion · in 3 records
- OVA · 3,4-dihydroxy-2-methoxy-4-methyl-3-[2-methyl-3-(3-methyl-but-2-enyl) -oxiranyl]-cyclohexanone · in 3 records
- EYL · ~{N}-oxidanyl-1-(phenylmethyl)pyrrolo[2,3-b]pyridine-4-carboxamide · in 2 records
- TN4 · (1R,2S,3S,4R)-4-hydroxy-2-methoxy-4-methyl-3-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]cyclohexyl (chloroacetyl)carbamate · in 2 records
- EYF · 1-[(3-methoxyphenyl)methyl]-~{N}-oxidanyl-pyrrolo[2,3-b]pyridine-5-carboxamide · in 1 record
Experiment against prediction
- 2GZ5 chain A against the predicted model P53582: TM-score 1.00, RMSD 0.20 Å
- 2GZ5 chain A against the predicted model P53582: TM-score 1.00, RMSD 0.20 Å
- 2NQ6 chain A against the predicted model P53582: TM-score 1.00, RMSD 0.20 Å
- 2NQ6 chain A against the predicted model P53582: TM-score 1.00, RMSD 0.20 Å
- 4U70 chain A against the predicted model P53582: TM-score 1.00, RMSD 0.21 Å
- 4U70 chain A against the predicted model P53582: TM-score 1.00, RMSD 0.21 Å
- 4IKT chain A against the predicted model P53582: TM-score 1.00, RMSD 0.21 Å
- 4IKT chain A against the predicted model P53582: TM-score 1.00, RMSD 0.21 Å
- 2B3K chain A against the predicted model P53582: TM-score 1.00, RMSD 0.22 Å
- 2B3K chain A against the predicted model P53582: TM-score 1.00, RMSD 0.22 Å
Elsewhere
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