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Ligand · YZ6

YZ6 · (E,2R,3R,4S,5R)-N-[(3R)-3-(furan-2-yl)-3-phenyl-propyl]-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide

YZ6, (E,2R,3R,4S,5R)-N-[(3R)-3-(furan-2-yl)-3-phenyl-propyl]-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide (C25 H35 N O6, 445.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site…

Component
YZ6
Formula
C25 H35 N O6
Class
ligand
Structures
2
PDB entries
1

Binding sites

YZ6 in 2 structures; the first of them:

  • 4FLL · Human MetAP1 with bengamide analog YZ6, in Mn form · YZ6 A503 · binds PRO192, TYR195, PHE198, CYS203, CYS211, HIS212, ASP229, THR231 and 16 more
  • 4FLL · Human METAP1 with bengamide analog YZ6, in mn form · YZ6 A503 · binds PRO192, TYR195, PHE198, CYS203, CYS211, HIS212, ASP229, THR231 and 16 more

Residues it binds most

CYS 2, HIS 2, ASP 2, GLU 2, PHE 2, PRO 2, THR 2, TYR 2, ASN 2, GLN 2 (residue and the binding sites it lines).

Found with

  • MN · Manganese (II) ion
  • NA · Sodium ion

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