Ligand · Y08
Y08 · (E,2R,3R,4S,5R)-N-[[(3S)-1-cyclopropylcarbonylpiperidin-3-yl]methyl]-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide
Y08, (E,2R,3R,4S,5R)-N-[[(3S)-1-cyclopropylcarbonylpiperidin-3-yl]methyl]-2-methoxy-8,8-dimethyl-3,4,5-tris(oxidanyl)non-6-enamide (C22 H38 N2 O6, 426.6 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries).…
- Component
- Y08
- Formula
- C22 H38 N2 O6
- Class
- ligand
- Structures
- 4
- PDB entries
- 2
Binding sites
Y08 in 4 structures; the first of them:
- 3PKC · M. tuberculosis MetAP with bengamide analog Y08, in Mn form · Y08 A288 · binds GLU35, GLY36, THR94, TYR97, PHE100, CYS105, CYS113, HIS114 and 16 more
- 4FLJ · Human MetAP1 with bengamide analog Y08, in Mn form · Y08 A503 · binds GLU128, PRO192, TYR195, PHE198, CYS203, CYS211, HIS212, ASP229 and 12 more
- 3PKC · M. tuberculosis metap with bengamide analog Y08, in mn form · Y08 A288 · binds GLU35, GLY36, THR94, TYR97, PHE100, CYS105, CYS113, HIS114 and 16 more
- 4FLJ · Human METAP1 with bengamide analog Y08, in mn form · Y08 A503 · binds GLU128, PRO192, TYR195, PHE198, CYS203, CYS211, HIS212, ASP229 and 12 more
Residues it binds most
GLU 4, HIS 4, CYS 4, PHE 4, ASP 4, THR 4, TYR 4, GLN 4, GLY 2, MET 4 (residue and the binding sites it lines).
Found with
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