UniProt P47205
UDP-3-O-acyl-N-acetylglucosamine deacetylase (P47205)
UDP-3-O-acyl-N-acetylglucosamine deacetylase (UniProt P47205), EC 3.5.1.-, 3.5.1.108: 64 experimental structures on GenesisL1, 34 ligands bound, 29 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P47205
- Protein
- UDP-3-O-acyl-N-acetylglucosamine deacetylase
- EC
- 3.5.1.-, 3.5.1.108
- Experimental structures
- 64
- Predicted models
- 0
- Ligands
- 34
- Pockets
- 29 · 6 records with a druggable one
Structures
64 records of P47205 in the MolNFT archive: 64 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2VES | Crystal Structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor | x-ray diffraction | A, B, C | — | — |
| 2VES | Crystal structure of lpxc from pseudomonas aeruginosa complexed with the potent bb-78485 inhibitor | x-ray diffraction | A, B, C | — | — |
| 3P3E | Crystal Structure of the PSEUDOMONAS AERUGINOSA LpxC/LPC-009 complex | x-ray diffraction | A | — | — |
| 3P3E | Crystal structure of the pseudomonas aeruginosa LPXC/LPC-009 complex | x-ray diffraction | A | — | — |
| 3U1Y | Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections | x-ray diffraction | A, B | — | — |
| 3U1Y | Potent inhibitors of lpxc for the treatment of gram-negative infections | x-ray diffraction | A, B | — | — |
| 3UHM | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase in complex with inhibitor | x-ray diffraction | A | — | — |
| 3UHM | Udp-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase in complex with inhibitor | x-ray diffraction | A | — | — |
| 4FW3 | Crystal Structure of the LpxC in complex with N-[(2S)-3-AMINO-1-(HYDROXYAMINO)-1-OXOPROPAN-2-YL]-4-(… | x-ray diffraction | A, B, C, D | — | — |
| 4FW3 | Crystal structure of the lpxc in complex with N-[(2S)-3-amino-1… | x-ray diffraction | A, B, C, D | — | — |
| 4FW4 | Crystal Structure of the LpxC in complex with N-[(1S,2R)-2-HYDROXY-1-(HYDROXYCARBAMOYL)PROPYL]-4-(4… | x-ray diffraction | A, B, C, D | — | — |
| 4FW4 | Crystal structure of the lpxc in complex with N-[(1S,2R)-2-hydroxy-1… | x-ray diffraction | A, B, C, D | — | — |
| 4FW5 | Crystal Structure of the LpxC in complex with 4'-BROMO-N-[(2S,3R)-3-HYDROXY-1-(HYDROXYAMINO)-1-OXOBU… | x-ray diffraction | A, B, C, D | — | — |
| 4FW5 | Crystal structure of the lpxc in complex with 4'-bromo-N-[(2S,3R)-3… | x-ray diffraction | A, B, C, D | — | — |
| 4FW6 | Crystal Structure of the LpxC in complex with N-[(2S,3R)-3-HYDROXY-1-(HYDROXYAMINO)-1-OXOBUTAN-2-YL]… | x-ray diffraction | A, B, C, D | — | — |
| 4FW6 | Crystal structure of the lpxc in complex with N-[(2S,3R)-3-hydroxy-1… | x-ray diffraction | A, B, C, D | — | — |
| 4FW7 | Crystal Structure of the LpxC in complex with N-[(2S,3R)-3-HYDROXY-1-(HYDROXYAMINO)-1-OXOBUTAN-2-YL]… | x-ray diffraction | A, B, C, D | — | — |
| 4FW7 | Crystal structure of the lpxc in complex with N-[(2S,3R)-3-hydroxy-1… | x-ray diffraction | A, B, C, D | — | — |
| 4J3D | Pseudomonas aeruginosa LpxC in complex with a hydroxamate inhibitor | x-ray diffraction | A, B | — | — |
| 4J3D | Pseudomonas aeruginosa lpxc in complex with a hydroxamate inhibitor | x-ray diffraction | A, B | — | — |
| 4LCF | Crystal structure of the Pseudomonas aeruginosa LPXC/LPC-014 complex | x-ray diffraction | A | — | — |
| 4LCF | Crystal structure of the pseudomonas aeruginosa LPXC/LPC-014 complex | x-ray diffraction | A | — | — |
| 4LCG | Crystal structure of the Pseudomonas aeruginosa LPXC/LPC-050 complex | x-ray diffraction | A | — | — |
| 4LCG | Crystal structure of the pseudomonas aeruginosa LPXC/LPC-050 complex | x-ray diffraction | A | — | — |
| 4LCH | Crystal structure of the Pseudomonas aeruginosa LPXC/LPC-051 complex | x-ray diffraction | A | — | — |
| 4LCH | Crystal structure of the pseudomonas aeruginosa LPXC/LPC-051 complex | x-ray diffraction | A | — | — |
| 4OKG | LpxC from P.aeruginosa with the inhibitor 6-(benzimidazol-1-yl)-5-[4-[2-[6-[(4-methylpiperazin-1-yl)… | x-ray diffraction | A, B | — | — |
| 4OKG | Lpxc from P.AERUGINOSA with the inhibitor 6-(benzimidazol-1-yl)-5-[4… | x-ray diffraction | A, B | — | — |
| 5DRQ | Crystal structure of the Pseudomonas aeruginosa LpxC/LPC-040 complex | x-ray diffraction | A | ZN, 5EM, NO3 | 3 (best 0.67) |
| 5DRQ | Crystal structure of the pseudomonas aeruginosa LPXC/LPC-040 complex | x-ray diffraction | A | — | — |
| 5DRR | Crystal structure of the pseudomonas aeruginosa LPXC/LPC-058 complex | x-ray diffraction | A | — | — |
| 5N8C | Crystal structure of pseudomonas aeruginosa lpxc complexed with inhibitor | x-ray diffraction | A, B | ZN, 8Q8, CL | — |
| 5U39 | Pseudomonas aeruginosa lpxc in complex with chir-090 | x-ray diffraction | A | ZN, C90 | — |
| 5U3B | Pseudomonas aeruginosa lpxc in complex with nvs-lpxc-01 | x-ray diffraction | A, B | ZN, 7TD | — |
| 5UPG | Crystal structure of LpxC from Pseudomonas aeruginosa in complex with PF-5081090 | x-ray diffraction | A | 8GJ, ZN, CL | 4 (best 0.69) |
| 5UPG | Crystal structure of lpxc from pseudomonas aeruginosa in complex with pf-5081090 | x-ray diffraction | A | 8GJ, ZN, CL | — |
| 5VWM | Crystal structure of UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) from… | x-ray diffraction | A | C90, ZN, CL, CA | — |
| 5VWM | Crystal structure of udp-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (lpxc) from… | x-ray diffraction | A | C90, ZN, CL, CA | — |
| 6E54 | Crystal structure of lpxc from pseudomonas aeruginosa in complex with ligand PT802 | x-ray diffraction | A | HUM, JCG, ZN, CL | — |
| 6MAE | Chain a. udp-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase pa-lpxc complexed with… | x-ray diffraction | A | JBA, ZN | — |
| 6MO4 | Co-crystal structure of P. aeruginosa lpxc-50067 complex | x-ray diffraction | A | MG, JWM | — |
| 6MO5 | Co-Crystal structure of P. aeruginosa LpxC-50228 complex | x-ray diffraction | A | JWP, MG | 4 (best 0.72) |
| 6MO5 | Co-crystal structure of P. aeruginosa lpxc-50228 complex | x-ray diffraction | A | JWP, MG | — |
| 7CI4 | Crystal structure of P.AERUGINOSA lpxc in complex with inhibitor | x-ray diffraction | A, B | FXU, ZN, MG, CL | — |
| 7CI5 | Crystal structure of P.AERUGINOSA lpxc in complex with inhibitor | x-ray diffraction | A, B, C, D | FXX, ZN | — |
| 7CI6 | Crystal structure of P.AERUGINOSA lpxc in complex with inhibitor | x-ray diffraction | A, B | FY6, ZN, CL | — |
| 7CI7 | Crystal structure of P.AERUGINOSA lpxc in complex with inhibitor | — | — | — | |
| 7CI8 | Crystal structure of P.aeruginosa LpxC in complex with inhibitor | x-ray diffraction | A, B | FYF, ZN, MG | 11 (best 0.73) |
| 7CI8 | Crystal structure of P.AERUGINOSA lpxc in complex with inhibitor | x-ray diffraction | A, B | FYF, ZN | — |
| 7CI9 | Crystal structure of P.AERUGINOSA lpxc in complex with inhibitor | x-ray diffraction | A | FYL, PO4, ZN | — |
| 7CIA | Crystal structure of P.aeruginosa LpxC in complex with inhibitor | x-ray diffraction | A | MPB, ZN | 4 (best 0.69) |
| 7CIA | Crystal structure of P.AERUGINOSA lpxc in complex with inhibitor | x-ray diffraction | A | MPB, ZN | — |
| 7CIB | Crystal structure of P.AERUGINOSA lpxc in complex with inhibitor | x-ray diffraction | A | FYR, ZN | — |
| 7CIC | Crystal structure of P.AERUGINOSA lpxc in complex with inhibitor | x-ray diffraction | A, B | FZ0, ZN | — |
| 7CID | Crystal structure of P.AERUGINOSA lpxc in complex with inhibitor | x-ray diffraction | A | FZ3, ZN | — |
| 7CIE | Crystal structure of P.AERUGINOSA lpxc in complex with inhibitor | x-ray diffraction | A, B | FZ6, ZN | — |
| 7DEL | Crystal structure of P.AERUGINOSA lpxc in complex with inhibitor | x-ray diffraction | A | ZN, H4L | — |
| 7DEM | Crystal structure of P.AERUGINOSA lpxc in complex with inhibitor | x-ray diffraction | A | ZN, H4O | — |
| 7DEN | Crystal structure of P.aeruginosa LpxC in complex with inhibitor | x-ray diffraction | A | ZN, H4R | — |
| 7DEN | Crystal structure of P.AERUGINOSA lpxc in complex with inhibitor | x-ray diffraction | A | ZN, H4R | — |
4 records more on the page itself.
Ligands
- ZN · Zinc ion · in 29 records
- CL · Chloride ion · in 8 records
- MG · Magnesium ion · in 5 records
- C90 · N-{(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl}-4-{[4-(morpholin-4-ylmethyl)phenyl]ethynyl}benzamide · in 3 records
- 8GJ · (2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl) butanamide · in 2 records
- CA · Calcium ion · in 2 records
- FYF · (1S)-1-[1-[(5-phenyl-1,2-oxazol-3-yl)methyl]imidazol-2-yl]ethanol · in 2 records
- H4R · 4-[(1~{R},5~{S})-6-[2-[4-[3-[[2-[(1~{S})-1-oxidanylethyl]imidazol-1-yl]methyl]-1,2-oxazol-5-yl]phenyl]ethynyl]-3-azabicyclo[3.1.0]hexan-3-yl]butanoic acid · in 2 records
- JWP · N-[(2S)-1-(hydroxyamino)-3-methyl-3-{[(oxetan-3-yl) methyl]sulfonyl}-1-oxobutan-2-yl]-4-(6-hydroxyhexa-1, 3-diyn-1-yl)benzamide · in 2 records
- MPB · 4-hydroxy-benzoic acid methyl ester · in 2 records
- SO4 · Sulfate ion · in 2 records
- 5EM · N-[(2S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]benzamide · in 1 record
- 7TD · N-[(2S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-[(but-2-yn-1-yl)oxy]benzamide · in 1 record
- 7TF · (2R,4R)-1-cyclopropylcarbonyl-4-[[(2S,4S)-4-fluoranylpyrrolidin-2-yl]carbonylamino]-N-[[4-[2-[4-(morpholin-4-ylmethyl)phenyl]ethynyl]phenyl]methyl]pyrrolidine-2-carboxamide · in 1 record
- 8Q8 · (2~{S})-3-azanyl-2-[[(1~{R})-5-[2-[4-[[2-(hydroxymethyl)imidazol-1-yl]methyl]phenyl]ethynyl]-2, 3-dihydro-1~{H}-inden-1-yl]amino]-3-methyl-~{N}-oxidanyl-butanamide · in 1 record
- FXU · (2R)-2-azanyl-4-methylsulfonyl-N-[3-(trifluoromethyloxy)phenyl]butanamide · in 1 record
- FXX · (3R)-3-azanyl-4-oxidanylidene-4-[[3-(trifluoromethyloxy)phenyl]amino]butanoic acid · in 1 record
- FY6 · (1S)-1-[1-[3-(4-chlorophenyl)propyl]imidazol-2-yl]ethanol · in 1 record
- FYL · 2-azanyl-2-[[4-[2-[3-[[2-[(1S)-1-oxidanylethyl]imidazol-1-yl]methyl]-1,2-oxazol-5-yl]ethynyl]phenoxy]methyl]propane-1,3-diol · in 1 record
- FYR · 2-oxidanyl-4-phenyl-benzoic acid · in 1 record
- FZ0 · 2-azanyl-N-[3-(trifluoromethyloxy)phenyl]ethanamide · in 1 record
- FZ3 · 1-[3-(4-chlorophenyl)propyl]imidazole · in 1 record
- FZ6 · (2R)-2-azanyl-3-oxidanyl-N-[3-(trifluoromethyloxy) phenyl]propanamide · in 1 record
- H4L · 3-[4-[2-[3-[[2-[(1~{S})-1-oxidanylethyl]imidazol-1-yl]methyl]-1,2-oxazol-5-yl]ethynyl]phenyl]propan-1-ol · in 1 record
- H4O · 5-[4-[3-[[2-[(1~{S})-1-oxidanylethyl]imidazol-1-yl]methyl]-1,2-oxazol-5-yl]phenyl]pent-4-yn-1-ol · in 1 record
- HUM · (2S)-4-{4-[4-(benzyloxy)-2-fluorophenyl]-2-oxopyridin-1(2H)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl) butanamide · in 1 record
- JBA · (2R)-3-{(5S)-3-[4-(cyclopropylethynyl)phenyl]-2-oxo-1, 3-oxazolidin-5-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl)propanamide · in 1 record
- JCG · (2R)-4-{4-[4-(benzyloxy)-2-fluorophenyl]-2-oxopyridin-1(2H)-yl}-N-hydroxy-2-methyl-2-(methylsulfonyl) butanamide · in 1 record
- JWM · N-[(2R)-1-(hydroxyamino)-3-methyl-3-(methylsulfonyl)-1-oxobutan-2-yl]-4-(6-hydroxyhexa-1,3-diyn-1-yl) benzamide · in 1 record
- NO3 · Nitrate ion · in 1 record
Elsewhere
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