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Ligand · 8GJ

8GJ · (2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl) butanamide

8GJ, (2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl) butanamide (C18 H21 F N2 O6 S, 412.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site…

Component
8GJ
Formula
C18 H21 F N2 O6 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

8GJ in 2 structures; the first of them:

  • 5UPG · Crystal structure of LpxC from Pseudomonas aeruginosa in complex with PF-5081090 · 8GJ A401 · binds LEU18, HIS19, MET62, GLU77, HIS78, THR190, PHE191, GLY192 and 13 more
  • 5UPG · Crystal structure of lpxc from pseudomonas aeruginosa in complex with pf-5081090 · 8GJ A401 · binds LEU18, HIS19, MET62, GLU77, HIS78, THR190, PHE191, GLY192 and 10 more

Residues it binds most

SER 3, PHE 4, HIS 2, GLY 4, LEU 4, ALA 4, ILE 4, MET 4, THR 4, TYR 2 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • CL · Chloride ion
  • EDO · 1,2-ethanediol

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