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UniProt P46669

DNA-directed RNA polymerase I subunit RPA43 (P46669)

DNA-directed RNA polymerase I subunit RPA43 (UniProt P46669): 53 experimental structures and 1 predicted model on GenesisL1, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt
P46669
Protein
DNA-directed RNA polymerase I subunit RPA43
Experimental structures
53
Predicted models
1
Pockets
11 · 3 records with a druggable one

Structures

54 records of P46669 in the MolNFT archive: 53 experimental, 1 predicted.

EntryTitleMethodChainsLigandsPockets
2RF4Crystal structure of the RNA Polymerase I subcomplex A14/43x-ray diffractionA, C, E——
2RF4Crystal structure of the RNA polymerase I subcomplex A14/43x-ray diffractionA, C, E——
4C2MStructure of RNA polymerase I at 2.8 A resolutionx-ray diffraction4, G, O, V——
4C2MStructure of RNA polymerase I at 2.8 a resolutionx-ray diffraction4, G, O, V——
4C3HStructure of 14-subunit RNA polymerase I at 3.27 A resolution, crystal form C2-93x-ray diffractionG——
4C3HStructure of 14-subunit RNA polymerase I at 3.27 a resolution, crystal form C2-93x-ray diffractionG——
4C3IStructure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100x-ray diffractionG——
4C3IStructure of 14-subunit RNA polymerase I at 3.0 a resolution, crystal form C2-100x-ray diffractionG——
4C3JStructure of 14-subunit RNA polymerase I at 3.35 A resolution, crystal form C2-90x-ray diffractionG——
4C3JStructure of 14-subunit RNA polymerase I at 3.35 a resolution, crystal form C2-90x-ray diffractionG——
5G5LRNA polymerase I-RRN3 complex at 4.8 a resolutionelectron microscopyG——
5LMXMonomeric RNA polymerase I at 4.9 a resolutionelectron microscopyG——
5M3FYeast RNA polymerase I elongation complex at 3.8Aelectron microscopyG——
5M3MFree monomeric RNA polymerase I at 4.0A resolutionelectron microscopyG——
5M3MFree monomeric RNA polymerase I at 4.0A resolutionelectron microscopyG——
5M5WRNA Polymerase I open complexelectron microscopyG—3 (best 0.81)
5M5WRNA polymerase I open complexelectron microscopyG——
5M5XRNA Polymerase I elongation complex 1electron microscopyG——
5M5XRNA polymerase I elongation complex 1electron microscopyG——
5M5YRNA polymerase I elongation complex 2electron microscopyG——
5M64RNA polymerase I elongation complex with A49 tandem winged helix domainelectron microscopyG——
5N5YCryo-EM structure of RNA polymerase I in complex with RRN3 and core factor (orientation III)electron microscopyG——
5N5ZCryo-EM structure of RNA polymerase I in complex with Rrn3 and Core Factor (Orientation II)electron microscopyG—3 (best 0.82)
5N5ZCryo-EM structure of RNA polymerase I in complex with RRN3 and core factor (orientation II)electron microscopyG——
5N60Cryo-EM structure of RNA polymerase I in complex with RRN3 and core factor (orientation I)electron microscopyG——
5N61RNA polymerase I initially transcribing complexelectron microscopyG——
5OA1RNA polymerase I pre-initiation complexelectron microscopyG——
5W5YRNA polymerase I initial transcribing complexelectron microscopyG——
5W64RNA polymerase I initial transcribing complex state 1electron microscopyG——
5W65RNA polymerase I initial transcribing complex state 2electron microscopyG——
5W66RNA polymerase I initial transcribing complex state 3electron microscopyG——
6H67Yeast RNA polymerase I elongation complex stalled by cyclobutane pyrimidine dimer (CPD)electron microscopyG——
6H67Yeast RNA polymerase I elongation complex stalled by cyclobutane pyrimidine dimer (cpd)electron microscopyG——
6H68Yeast RNA polymerase I elongation complex stalled by cyclobutane pyrimidine dimer (CPD) with…electron microscopyG——
6H68Yeast RNA polymerase I elongation complex stalled by cyclobutane pyrimidine dimer (cpd) with…electron microscopyG——
6HKOYeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPPelectron microscopyG——
6HKOYeast RNA polymerase I elongation complex bound to nucleotide analog gmpcppelectron microscopyG——
6HLQYeast RNA polymerase I* elongation complex bound to nucleotide analog GMPCPPelectron microscopyG——
6HLQYeast RNA polymerase I* elongation complex bound to nucleotide analog gmpcppelectron microscopyG——
6HLRYeast RNA polymerase I elongation complex bound to nucleotide analog gmpcpp (core focused)electron microscopyG——
6HLSYeast apo RNA polymerase I*electron microscopyG——
6HLSYeast apo RNA polymerase I*electron microscopyG——
6RQHRNA Polymerase I Closed Conformation 1 (CC1)electron microscopyG——
6RQHRNA polymerase I closed conformation 1 (CC1)electron microscopyG——
6RQLRNA polymerase I closed conformation 2 (CC2)electron microscopyG——
6RQTRNA Polymerase I-tWH-Rrn3-DNAelectron microscopyG——
6RQTRNA polymerase I-twh-RRN3-DNAelectron microscopyG——
6RRDRNA polymerase I pre-initiation complex DNA opening intermediate 1electron microscopyG——
6RUIRNA polymerase I pre-initiation complex DNA opening intermediate 2electron microscopyG——
6RUORNA Polymerase I Open Complex conformation 1electron microscopyG—3 (best 0.85)
6RUORNA polymerase I open complex conformation 1electron microscopyG——
6RWERNA polymerase I open complex conformation 2electron microscopyG——
6TPSEarly intermediate RNA polymerase I pre-initiation complex - eipicelectron microscopyG——
P46669AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase I subunit RPA43 (P46669)predictedA—2 (best 0.39)

Experiment against prediction

Elsewhere

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