GL1X · GenesisL1 explorer

MolNFT v1 · #384852 · protein

AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase I subunit RPA43 (P46669)

P46669: “AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase I subunit RPA43 (P46669)”. 2 pockets (best druggability 0.39). MolNFT v1 #384852 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession
P46669
Type
protein
Length
326 residues
Chains
1
Collection
MolNFT v1 / AlphaFold
Contract
0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner
0x1620032580Cf2476f2BD828E85045251C289D3d8
Molecule
DNA-directed RNA polymerase I subunit RPA43
UniProt
P46669
Pockets
2 · best druggability 0.39

Structure

1 distinct chain · 13% helix, 28% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ADNA-directed RNA polymerase I subunit RPA43protein32613% helix, 28% strandP46669

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
11470.390.7322empty
2550.300.7512empty

Compared structures

  • 4C3I · Structure of 14-subunit RNA polymerase I at 3.0 a resolution, crystal form C2-100 · an experimental structure of the same protein · chain A against G, TM-score 0.60
  • 4C3I · Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100 · an experimental structure of the same protein · chain A against G, TM-score 0.60
  • 4C3J · Structure of 14-subunit RNA polymerase I at 3.35 A resolution, crystal form C2-90 · an experimental structure of the same protein · chain A against G, TM-score 0.59
  • 4C3J · Structure of 14-subunit RNA polymerase I at 3.35 a resolution, crystal form C2-90 · an experimental structure of the same protein · chain A against G, TM-score 0.59
  • 4C3H · Structure of 14-subunit RNA polymerase I at 3.27 a resolution, crystal form C2-93 · an experimental structure of the same protein · chain A against G, TM-score 0.59
  • 4C3H · Structure of 14-subunit RNA polymerase I at 3.27 A resolution, crystal form C2-93 · an experimental structure of the same protein · chain A against G, TM-score 0.59
  • 5M5W · RNA polymerase I open complex · an experimental structure of the same protein · chain A against G, TM-score 0.58
  • 4C2M · Structure of RNA polymerase I at 2.8 A resolution · an experimental structure of the same protein · chain A against V, TM-score 0.58
  • 4C2M · Structure of RNA polymerase I at 2.8 a resolution · an experimental structure of the same protein · chain A against V, TM-score 0.58
  • 6RRD · RNA polymerase I pre-initiation complex DNA opening intermediate 1 · an experimental structure of the same protein · chain A against G, TM-score 0.57
  • 6RUI · RNA polymerase I pre-initiation complex DNA opening intermediate 2 · an experimental structure of the same protein · chain A against G, TM-score 0.57
  • 5OA1 · RNA polymerase I pre-initiation complex · an experimental structure of the same protein · chain A against G, TM-score 0.57

Analyse

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