Research workbench
AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase I subunit RPA43 (P46669)
Analyse AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase I subunit… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P46669
- Type
- protein
- Length
- 326 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x1620032580Cf2476f2BD828E85045251C289D3d8
- Molecule
- DNA-directed RNA polymerase I subunit RPA43
- UniProt
- P46669
- Pockets
- 2 · best druggability 0.39
Structure
1 distinct chain · 13% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-directed RNA polymerase I subunit RPA43 | protein | 326 | 13% helix, 28% strand | P46669 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 147 | 0.39 | 0.73 | 22 | empty |
| 2 | 55 | 0.30 | 0.75 | 12 | empty |
Compared structures
- 4C3I · Structure of 14-subunit RNA polymerase I at 3.0 a resolution, crystal form C2-100 · an experimental structure of the same protein · chain A against G, TM-score 0.60
- 4C3I · Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100 · an experimental structure of the same protein · chain A against G, TM-score 0.60
- 4C3J · Structure of 14-subunit RNA polymerase I at 3.35 A resolution, crystal form C2-90 · an experimental structure of the same protein · chain A against G, TM-score 0.59
- 4C3J · Structure of 14-subunit RNA polymerase I at 3.35 a resolution, crystal form C2-90 · an experimental structure of the same protein · chain A against G, TM-score 0.59
- 4C3H · Structure of 14-subunit RNA polymerase I at 3.27 a resolution, crystal form C2-93 · an experimental structure of the same protein · chain A against G, TM-score 0.59
- 4C3H · Structure of 14-subunit RNA polymerase I at 3.27 A resolution, crystal form C2-93 · an experimental structure of the same protein · chain A against G, TM-score 0.59
- 5M5W · RNA polymerase I open complex · an experimental structure of the same protein · chain A against G, TM-score 0.58
- 4C2M · Structure of RNA polymerase I at 2.8 A resolution · an experimental structure of the same protein · chain A against V, TM-score 0.58
- 4C2M · Structure of RNA polymerase I at 2.8 a resolution · an experimental structure of the same protein · chain A against V, TM-score 0.58
- 6RRD · RNA polymerase I pre-initiation complex DNA opening intermediate 1 · an experimental structure of the same protein · chain A against G, TM-score 0.57
- 6RUI · RNA polymerase I pre-initiation complex DNA opening intermediate 2 · an experimental structure of the same protein · chain A against G, TM-score 0.57
- 5OA1 · RNA polymerase I pre-initiation complex · an experimental structure of the same protein · chain A against G, TM-score 0.57
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P46669
- Elsewhere: UniProt P46669 · AlphaFold DB P46669
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