UniProt P45481
CREB-binding protein (P45481)
CREB-binding protein (UniProt P45481), EC 2.3.1.-, 2.3.1.48: 48 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P45481
- Protein
- CREB-binding protein
- EC
- 2.3.1.-, 2.3.1.48
- Experimental structures
- 48
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 8 · 1 record with a druggable one
Structures
49 records of P45481 in the MolNFT archive: 48 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1F81 | Solution structure of the TAZ2 domain of the transcriptional adaptor protein cbp | solution nmr | A | ZN | — |
| 1F81 | Solution structure of the TAZ2 domain of the transcriptional adaptor protein cbp | solution nmr | A | — | — |
| 1JJS | NMR Structure of IBiD, A Domain of CBP/p300 | solution nmr | A | — | — |
| 1JJS | NMR structure of ibid, a domain of CBP/P300 | solution nmr | A | — | — |
| 1KBH | Mutual Synergistic Folding in the Interaction Between Nuclear Receptor Coactivators CBP and ACTR | solution nmr | B | — | — |
| 1KBH | Mutual synergistic folding in the interaction between nuclear receptor coactivators cbp and actr | solution nmr | B | — | — |
| 1KDX | Kix domain of mouse cbp (creb binding protein) in complex with phosphorylated kinase inducible… | solution nmr | A | — | — |
| 1KDX | Kix domain of mouse cbp (creb binding protein) in complex with phosphorylated kinase inducible… | solution nmr | A | — | — |
| 1L8C | Structural basis for hif-1ALPHA/CBP recognition in the cellular hypoxic response | solution nmr | A | ZN | 2 (best 0.43) |
| 1L8C | Structural basis for hif-1ALPHA/CBP recognition in the cellular hypoxic response | solution nmr | A | — | — |
| 1SB0 | Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb | solution nmr | A | — | — |
| 1SB0 | Solution structure of the kix domain of cbp bound to the transactivation domain of C-myb | solution nmr | A | — | — |
| 1TOT | ZZ Domain of CBP- a Novel Fold for a Protein Interaction Module | solution nmr | A | ZN | — |
| 1TOT | Zz domain of cbp- a novel fold for a protein interaction module | solution nmr | A | — | — |
| 1U2N | Structure CBP TAZ1 Domain | solution nmr | A | ZN | 1 (best 0.41) |
| 1U2N | Structure cbp TAZ1 domain | solution nmr | A | — | — |
| 2AGH | Structural basis for cooperative transcription factor binding to the CBP coactivator | solution nmr | B | — | — |
| 2AGH | Structural basis for cooperative transcription factor binding to the cbp coactivator | solution nmr | B | — | — |
| 2C52 | Structural diversity in CBP p160 complexes | solution nmr | A | — | — |
| 2C52 | Structural diversity in cbp P160 complexes | solution nmr | A | — | — |
| 2KA6 | NMR structure of the CBP-TAZ2/STAT1-TAD complex | solution nmr | A | — | — |
| 2KA6 | NMR structure of the cbp-TAZ2/STAT1-tad complex | solution nmr | A | — | — |
| 2KKJ | Solution structure of the Nuclear coactivator binding domain of CBP | solution nmr | A | — | — |
| 2KKJ | Solution structure of the nuclear coactivator binding domain of cbp | solution nmr | A | — | — |
| 2L14 | Structure of CBP nuclear coactivator binding domain in complex with p53 TAD | solution nmr | A | — | — |
| 2L14 | Structure of cbp nuclear coactivator binding domain in complex with P53 tad | solution nmr | A | — | — |
| 2LQH | NMR structure of FOXO3a transactivation domains (CR2C-CR3) in complex with CBP KIX domain (2b3l… | solution nmr | A | — | — |
| 2LQH | NMR structure of FOXO3A transactivation domains (CR2C-CR3) in complex with cbp kix domain (2B3L… | solution nmr | A | — | — |
| 2LQI | NMR structure of FOXO3a transactivation domains (CR2C-CR3) in complex with CBP KIX domain (2l3b… | solution nmr | A | — | — |
| 2LQI | NMR structure of FOXO3A transactivation domains (CR2C-CR3) in complex with cbp kix domain (2L3B… | solution nmr | A | — | — |
| 2LWW | NMR structure of RelA-TAD/CBP-TAZ1 complex | solution nmr | A | — | — |
| 2LWW | NMR structure of rela-TAD/CBP-TAZ1 complex | solution nmr | A | — | — |
| 4I9O | Crystal Structure of GACKIX L664C Tethered to 1-10 | x-ray diffraction | A | — | — |
| 4I9O | Crystal structure of gackix L664C tethered to 1-10 | x-ray diffraction | A | — | — |
| 5HOU | Solution Structure of p53TAD-TAZ1 | solution nmr | A | ZN | — |
| 5HOU | Solution structure of P53TAD-TAZ1 | solution nmr | A | — | — |
| 5HP0 | Solution Structure of TAZ2-p53AD2 | solution nmr | A | ZN | — |
| 5HP0 | Solution structure of TAZ2-P53AD2 | solution nmr | A | — | — |
| 5HPD | Solution Structure of TAZ2-p53TAD | solution nmr | A | ZN | — |
| 5HPD | Solution structure of TAZ2-P53TAD | solution nmr | A | — | — |
| 5W0I | CREBBP Bromodomain in complex with Cpd8 (1-(3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-d… | x-ray diffraction | A | 9UA | 1 (best 0.46) |
| 5W0I | Crebbp bromodomain in complex with CPD8 (1-(3-(7-(difluoromethyl)-6… | x-ray diffraction | A | 9UA | — |
| 6DMX | HBZ56 in complex with KIX and c-Myb | x-ray diffraction | D, B, I, G | — | — |
| 6DMX | HBZ56 in complex with kix and C-myb | x-ray diffraction | D, B, I, G | — | — |
| 6DNQ | HBZ77 in complex with KIX and c-Myb | x-ray diffraction | D, B | — | 2 (best 0.42) |
| 6DNQ | HBZ77 in complex with kix and C-myb | x-ray diffraction | D, B | — | — |
| 7LVS | The CBP TAZ1 Domain in Complex with a CITED2-HIF-1-Alpha Fusion Peptide | x-ray diffraction | B | ZN | 2 (best 0.54) |
| 7LVS | The cbp TAZ1 domain in complex with a CITED2-hif-1-alpha fusion peptide | x-ray diffraction | B | ZN | — |
| P45481 | AlphaFold monomer V2.0 prediction for histone lysine acetyltransferase crebbp (P45481) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5W0I chain A against the predicted model P45481: TM-score 0.97, RMSD 0.69 Å
- 5W0I chain A against the predicted model P45481: TM-score 0.97, RMSD 0.69 Å
- 1F81 chain A against the predicted model P45481: TM-score 0.93, RMSD 1.11 Å
- 1F81 chain A against the predicted model P45481: TM-score 0.93, RMSD 1.11 Å
- 2KA6 chain A against the predicted model P45481: TM-score 0.90, RMSD 1.36 Å
- 2KA6 chain A against the predicted model P45481: TM-score 0.90, RMSD 1.36 Å
- 6DMX chain B against the predicted model P45481: TM-score 0.88, RMSD 1.41 Å
- 6DMX chain B against the predicted model P45481: TM-score 0.88, RMSD 1.41 Å
- 6DMX chain G against the predicted model P45481: TM-score 0.87, RMSD 1.53 Å
- 6DMX chain G against the predicted model P45481: TM-score 0.87, RMSD 1.53 Å
Elsewhere
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