MolNFT v1 · #146642 · protein

HBZ77 in complex with kix and C-myb

6DNQ · Bzip factor: “HBZ77 in complex with kix and C-myb”. X-ray diffraction, 2 pockets (best druggability 0.42). MolNFT v1 #146642 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6DNQ
Type: protein
Length: 278 residues
Chains: 5
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bzip factor; Transcriptional activator myb; Creb-binding protein
EC: 2.3.1.48
UniProt: Q2Q067, P06876, P45481
Pockets: 2 · best druggability 0.42

Structure

x-ray diffraction · 4 distinct chains · 74% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
E	Bzip factor	protein	54	83% helix, 0% strand	Q2Q067
C	Transcriptional activator myb	protein	26	65% helix, 0% strand	P06876
D, B	Creb-binding protein (EC 2.3.1.48)	protein	87	76% helix, 0% strand	P45481
A	Transcriptional activator myb	protein	24	54% helix, 0% strand	P06876

Ligands and binding sites

EDO · 1,2-ethanediol · additive · chains D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	137	0.42	0.75	15	empty
2	61	0.31	0.75	12	empty

Interfaces

4 interfaces between chains.

E–D · 888 Å² buried · 11 hydrogen bonds · protein-protein
E–B · 810 Å² buried · 10 hydrogen bonds · protein-protein
A–B · 776 Å² buried · 10 hydrogen bonds · protein-protein
C–D · 775 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

6DNQ · HBZ77 in complex with KIX and c-Myb · the same entry in another collection · chain B against B, TM-score 1.00
P45481 · AlphaFold monomer V2.0 prediction for histone lysine acetyltransferase crebbp (P45481) · a predicted model of the same protein · chain D against A, TM-score 0.84
P06876 · AlphaFold monomer V2.0 prediction for transcriptional activator myb (P06876) · a predicted model of the same protein · chain A against A, TM-score 0.60

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q2Q067
Every structure of UniProt P06876
Every structure of UniProt P45481
Elsewhere: RCSB PDB 6DNQ · PDBe 6DNQ · UniProt Q2Q067 · UniProt P06876 · UniProt P45481

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