Research workbench
HBZ77 in complex with kix and C-myb
Analyse HBZ77 in complex with kix and C-myb in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6DNQ
- Type
- protein
- Length
- 278 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bzip factor; Transcriptional activator myb; Creb-binding protein
- EC
- 2.3.1.48
- UniProt
- Q2Q067, P06876, P45481
- Pockets
- 2 · best druggability 0.42
Structure
x-ray diffraction · 4 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | Bzip factor | protein | 54 | 83% helix, 0% strand | Q2Q067 |
| C | Transcriptional activator myb | protein | 26 | 65% helix, 0% strand | P06876 |
| D, B | Creb-binding protein (EC 2.3.1.48) | protein | 87 | 76% helix, 0% strand | P45481 |
| A | Transcriptional activator myb | protein | 24 | 54% helix, 0% strand | P06876 |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · chains D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 137 | 0.42 | 0.75 | 15 | empty |
| 2 | 61 | 0.31 | 0.75 | 12 | empty |
Interfaces
4 interfaces between chains.
- E–D · 888 Ų buried · 11 hydrogen bonds · protein-protein
- E–B · 810 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 776 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 775 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 6DNQ · HBZ77 in complex with KIX and c-Myb · the same entry in another collection · chain B against B, TM-score 1.00
- P45481 · AlphaFold monomer V2.0 prediction for histone lysine acetyltransferase crebbp (P45481) · a predicted model of the same protein · chain D against A, TM-score 0.84
- P06876 · AlphaFold monomer V2.0 prediction for transcriptional activator myb (P06876) · a predicted model of the same protein · chain A against A, TM-score 0.60
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2Q067
- Every structure of UniProt P06876
- Every structure of UniProt P45481
- Elsewhere: RCSB PDB 6DNQ · PDBe 6DNQ · UniProt Q2Q067 · UniProt P06876 · UniProt P45481
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