MolNFT v1 · #31000 · protein
Structural basis for cooperative transcription factor binding to the cbp coactivator
2AGH · Myb proto-oncogene protein: “Structural basis for cooperative transcription factor binding to the cbp coactivator”. Solution nmr, 1 pocket (best druggability 0.37). MolNFT v1 #31000 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2AGH
- Type
- protein
- Length
- 143 residues
- Chains
- 3
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myb proto-oncogene protein; Crebbp protein; Zinc finger protein hrx
- UniProt
- P06876, P45481, Q03164
- Pockets
- 1 · best druggability 0.37
Structure
solution nmr · 3 distinct chains · 62% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myb proto-oncogene protein | protein | 25 | 68% helix, 0% strand | P06876 |
| B | Crebbp protein | protein | 87 | 70% helix, 0% strand | P45481 |
| C | Zinc finger protein hrx | protein | 31 | 32% helix, 0% strand | Q03164 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 69 | 0.37 | 0.78 | 16 | empty |
Interfaces
2 interfaces between chains.
- B–C · 824 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 763 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 2AGH · Structural basis for cooperative transcription factor binding to the CBP coactivator · the same entry in another collection · chain A against A, TM-score 1.00
- P45481 · AlphaFold monomer V2.0 prediction for histone lysine acetyltransferase crebbp (P45481) · a predicted model of the same protein · chain B against A, TM-score 0.80
- P06876 · AlphaFold monomer V2.0 prediction for transcriptional activator myb (P06876) · a predicted model of the same protein · chain A against A, TM-score 0.41
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06876
- Every structure of UniProt P45481
- Every structure of UniProt Q03164
- Elsewhere: RCSB PDB 2AGH · PDBe 2AGH · UniProt P06876 · UniProt P45481 · UniProt Q03164
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