UniProt Q03164
Histone-lysine N-methyltransferase 2A (Q03164)
Histone-lysine N-methyltransferase 2A (UniProt Q03164), EC 2.1.1.354, 2.1.1.43: 78 experimental structures on GenesisL1, 3 ligands bound, 11 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q03164
- Protein
- Histone-lysine N-methyltransferase 2A
- EC
- 2.1.1.354, 2.1.1.43
- Experimental structures
- 78
- Predicted models
- 0
- Ligands
- 3
- Pockets
- 11 · 5 records with a druggable one
Structures
78 records of Q03164 in the MolNFT archive: 78 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2AGH | Structural basis for cooperative transcription factor binding to the CBP coactivator | solution nmr | C | — | — |
| 2AGH | Structural basis for cooperative transcription factor binding to the cbp coactivator | solution nmr | C | — | — |
| 2J2S | Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone… | solution nmr | A | — | — |
| 2J2S | Solution structure of the nonmethyl-cpg-binding cxxc domain of the leukaemia-associated mll histone… | solution nmr | A | — | — |
| 2JYI | Solution structure of MLL CXXC domain | solution nmr | A | — | — |
| 2JYI | Solution structure of mll cxxc domain | solution nmr | A | — | — |
| 2KKF | Solution structure of MLL CXXC domain in complex with palindromic CPG DNA | solution nmr | A | — | — |
| 2KKF | Solution structure of mll cxxc domain in complex with palindromic cpg DNA | solution nmr | A | — | — |
| 2KU7 | Solution structure of MLL1 PHD3-Cyp33 RRM chimeric protein | solution nmr | A | — | — |
| 2KU7 | Solution structure of MLL1 PHD3-CYP33 rrm chimeric protein | solution nmr | A | — | — |
| 2KYU | The solution structure of the PHD3 finger of MLL | solution nmr | A | — | — |
| 2KYU | The solution structure of the PHD3 finger of mll | solution nmr | A | — | — |
| 2LXS | Allosteric communication in the KIX domain proceeds through dynamic re-packing of the hydrophobic… | solution nmr | B | — | — |
| 2LXS | Allosteric communication in the kix domain proceeds through dynamic re-packing of the hydrophobic… | solution nmr | B | — | — |
| 2LXT | Allosteric communication in the KIX domain proceeds through dynamic re-packing of the hydrophobic… | solution nmr | B | — | — |
| 2LXT | Allosteric communication in the kix domain proceeds through dynamic re-packing of the hydrophobic… | solution nmr | B | — | — |
| 2MSR | Solution structure of LEDGF/p75 IBD in complex with MLL1 peptide (140-160) | solution nmr | A | — | — |
| 2MSR | Solution structure of LEDGF/P75 ibd in complex with MLL1 peptide (140- 160) | solution nmr | A | — | — |
| 2MTN | Solution structure of MLL-IBD complex | solution nmr | A | — | — |
| 2MTN | Solution structure of mll-ibd complex | solution nmr | A | — | — |
| 2W5Y | Binary Complex of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product… | x-ray diffraction | A | — | — |
| 2W5Y | Binary complex of the mixed lineage leukaemia (MLL1) set domain with the cofactor product… | x-ray diffraction | A | — | — |
| 2W5Z | Ternary Complex of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product… | x-ray diffraction | A | — | — |
| 2W5Z | Ternary complex of the mixed lineage leukaemia (MLL1) set domain with the cofactor product… | x-ray diffraction | A | — | — |
| 3EG6 | Structure of WDR5 bound to MLL1 peptide | x-ray diffraction | C | — | — |
| 3EG6 | Structure of WDR5 bound to MLL1 peptide | x-ray diffraction | C | — | — |
| 3LQH | Crystal structure of MLL1 PHD3-Bromo in the free form | x-ray diffraction | A | — | — |
| 3LQH | Crystal structure of MLL1 PHD3-bromo in the free form | x-ray diffraction | A | — | — |
| 3LQI | Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me2 peptide | x-ray diffraction | A, B, C | — | — |
| 3LQI | Crystal structure of MLL1 PHD3-bromo complexed with H3(1-9)K4ME2 peptide | x-ray diffraction | A, B, C | — | — |
| 3LQJ | Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me3 peptide | x-ray diffraction | A, B | — | — |
| 3LQJ | Crystal structure of MLL1 PHD3-bromo complexed with H3(1-9)K4ME3 peptide | x-ray diffraction | A, B | — | — |
| 3P4F | Structural and biochemical insights into MLL1 core complex assembly and regulation. | x-ray diffraction | C | — | — |
| 3P4F | Structural and biochemical insights into MLL1 core complex assembly and regulation. | x-ray diffraction | C | — | — |
| 3U85 | Crystal structure of human menin in complex with MLL1 | x-ray diffraction | B | — | — |
| 3U85 | Crystal structure of human menin in complex with MLL1 | x-ray diffraction | B | — | — |
| 3U88 | Crystal structure of human menin in complex with MLL1 and LEDGF | x-ray diffraction | M, N | — | — |
| 3U88 | Crystal structure of human menin in complex with MLL1 and ledgf | x-ray diffraction | M, N | — | — |
| 4ESG | X-ray structure of WDR5-MLL1 Win motif peptide binary complex | x-ray diffraction | C, D | — | — |
| 4ESG | X-ray structure of WDR5-MLL1 win motif peptide binary complex | x-ray diffraction | C, D | — | — |
| 4GQ6 | Human menin in complex with MLL peptide | x-ray diffraction | B | — | — |
| 4GQ6 | Human menin in complex with mll peptide | x-ray diffraction | B | — | — |
| 4NW3 | Crystal structure of MLL CXXC domain in complex with a CpG DNA | x-ray diffraction | A | — | — |
| 4NW3 | Crystal structure of mll cxxc domain in complex with a cpg DNA | x-ray diffraction | A | — | — |
| 5F5E | The Crystal Structure of MLL1 SET domain with N3816I/Q3867L mutation | x-ray diffraction | A | ZN | — |
| 5F5E | The crystal structure of MLL1 set domain with N3816I/Q3867L mutation | x-ray diffraction | A | — | — |
| 5F6L | The crystal structure of MLL1 (N3861I/Q3867L) in complex with RbBP5 and Ash2L | x-ray diffraction | A | ZN | — |
| 5F6L | The crystal structure of MLL1 (N3861I/Q3867L) in complex with RBBP5 and ASH2L | x-ray diffraction | A | — | — |
| 5SVH | Crystal structure of the KIX domain of CBP in complex with a MLL/c-Myb chimera | x-ray diffraction | B | CL | — |
| 5SVH | Crystal structure of the kix domain of cbp in complex with a MLL/C-myb chimera | x-ray diffraction | B | CL | — |
| 6EMQ | Solution structure of the LEDGF/p75 IBD - MLL1 (aa 111-160) complex | solution nmr | A | — | 1 (best 0.29) |
| 6EMQ | Solution structure of the LEDGF/P75 ibd - MLL1 (aa 111-160) complex | solution nmr | A | — | — |
| 6KIU | Cryo-EM structure of human MLL1-ubNCP complex (3.2 angstrom) | electron microscopy | K | SAH, ZN | 4 (best 0.74) |
| 6KIU | Cryo-EM structure of human MLL1-ubncp complex (3.2 ångström) | electron microscopy | K | ZN | — |
| 6KIV | Cryo-EM structure of human MLL1-ubNCP complex (4.0 angstrom) | electron microscopy | K | SAH, ZN | 3 (best 0.77) |
| 6KIV | Cryo-EM structure of human MLL1-ubncp complex (4.0 ångström) | electron microscopy | K | ZN | — |
| 6KIX | Cryo-EM structure of human MLL1-NCP complex, binding mode1 | electron microscopy | K | ZN | — |
| 6KIX | Cryo-EM structure of human MLL1-ncp complex, binding MODE1 | electron microscopy | K | ZN | — |
| 6KIZ | Cryo-EM structure of human MLL1-ncp complex, binding MODE2 | electron microscopy | K | ZN | — |
| 6PWV | Cryo-EM structure of MLL1 core complex bound to the nucleosome | electron microscopy | C | ZN | — |
18 records more on the page itself.
Ligands
Experiment against prediction
- 2MTN chain A against the predicted model O75475: TM-score 0.63, RMSD 1.65 Å
- 2MTN chain A against the predicted model O75475: TM-score 0.63, RMSD 1.65 Å
- 6EMQ chain A against the predicted model O75475: TM-score 0.54, RMSD 2.29 Å
- 6EMQ chain A against the predicted model O75475: TM-score 0.54, RMSD 2.29 Å
Elsewhere
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