MolNFT v1 · #13337 · protein
Structural basis for hif-1ALPHA/CBP recognition in the cellular hypoxic response
1L8C · Creb-binding protein: “Structural basis for hif-1ALPHA/CBP recognition in the cellular hypoxic response”. Solution nmr, 1 ligand (ZN), 2 pockets (best druggability 0.43). MolNFT v1 #13337 on GenesisL1: 3D structure, binding sites…
- PDB
- 1L8C
- Type
- protein
- Length
- 146 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Creb-binding protein; Hypoxia-inducible factor 1 alpha
- UniProt
- P45481, Q16665
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.43
Structure
solution nmr · 2 distinct chains · 55% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Creb-binding protein | protein | 95 | 65% helix, 0% strand | P45481 |
| B | Hypoxia-inducible factor 1 alpha | protein | 51 | 37% helix, 0% strand | Q16665 |
Ligands and binding sites
- ZN · Zinc ion · metal · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 55 | 0.43 | 0.83 | 15 | empty |
| 2 | 117 | 0.39 | 0.75 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 2310 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 1L8C · Structural basis for hif-1ALPHA/CBP recognition in the cellular hypoxic response · the same entry in another collection · chain A against A, TM-score 1.00
- P45481 · AlphaFold monomer V2.0 prediction for histone lysine acetyltransferase crebbp (P45481) · a predicted model of the same protein · chain A against A, TM-score 0.76
- Q16665 · AlphaFold monomer V2.0 prediction for hypoxia-inducible factor 1-alpha (Q16665) · a predicted model of the same protein · chain B against A, TM-score 0.36
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P45481
- Every structure of UniProt Q16665
- Elsewhere: RCSB PDB 1L8C · PDBe 1L8C · UniProt P45481 · UniProt Q16665
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.