UniProt Q16665
Hypoxia-inducible factor 1-alpha (Q16665)
Hypoxia-inducible factor 1-alpha (UniProt Q16665): 36 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q16665
- Protein
- Hypoxia-inducible factor 1-alpha
- Experimental structures
- 36
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 3 · 1 record with a druggable one
Structures
37 records of Q16665 in the MolNFT archive: 36 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1H2K | Factor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide | x-ray diffraction | S | — | — |
| 1H2K | Factor inhibiting hif-1 alpha in complex with hif-1 alpha fragment peptide | x-ray diffraction | S | — | — |
| 1H2L | Factor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide | x-ray diffraction | S | — | — |
| 1H2L | Factor inhibiting hif-1 alpha in complex with hif-1 alpha fragment peptide | x-ray diffraction | S | — | — |
| 1H2M | Factor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide | x-ray diffraction | S | — | — |
| 1H2M | Factor inhibiting hif-1 alpha in complex with hif-1 alpha fragment peptide | x-ray diffraction | S | — | — |
| 1L3E | NMR Structures of the HIF-1alpha CTAD/p300 CH1 Complex | solution nmr | A | — | — |
| 1L3E | NMR structures of the hif-1ALPHA CTAD/P300 CH1 complex | solution nmr | A | — | — |
| 1L8C | Structural basis for hif-1ALPHA/CBP recognition in the cellular hypoxic response | solution nmr | B | — | — |
| 1L8C | Structural basis for hif-1ALPHA/CBP recognition in the cellular hypoxic response | solution nmr | B | — | — |
| 1LM8 | Structure of a HIF-1a-pVHL-ElonginB-ElonginC Complex | x-ray diffraction | H | — | — |
| 1LM8 | Structure of a hif-1A-pvhl-elonginb-elonginc complex | x-ray diffraction | H | — | — |
| 1LQB | Crystal structure of a hydroxylated HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B… | x-ray diffraction | D | — | — |
| 1LQB | Crystal structure of a hydroxylated hif-1 alpha peptide bound to the PVHL/ELONGIN-C/ELONGIN-B… | x-ray diffraction | D | — | — |
| 2ILM | Factor Inhibiting HIF-1 Alpha D201A Mutant in Complex with FE(II), Alpha-Ketoglutarate and HIF-1… | x-ray diffraction | S | — | — |
| 2ILM | Factor inhibiting hif-1 alpha D201A mutant in complex with FE(II), alpha-ketoglutarate and hif-1… | x-ray diffraction | S | — | — |
| 3HQR | PHD2:Mn:NOG:HIF1-alpha substrate complex | x-ray diffraction | S | — | — |
| 3HQR | PHD2:MN:NOG:HIF1-alpha substrate complex | x-ray diffraction | S | — | — |
| 3HQU | PHD2:Fe:UN9:partial HIF1-alpha substrate complex | x-ray diffraction | S | — | — |
| 3HQU | PHD2:FE:UN9:PARTIAL HIF1-alpha substrate complex | x-ray diffraction | S | — | — |
| 4AJY | von Hippel-Lindau protein-ElonginB-ElonginC complex, bound to Hif1- alpha peptide | x-ray diffraction | H | — | — |
| 4AJY | Von hippel-lindau protein-elonginb-elonginc complex, bound to HIF1- alpha peptide | x-ray diffraction | H | — | — |
| 4H6J | Identification of Cys 255 in HIF-1 as a novel site for development of covalent inhibitors of HIF-1… | x-ray diffraction | A | — | — |
| 4H6J | Identification of cys 255 in hif-1 as a novel site for development of covalent inhibitors of hif-1… | x-ray diffraction | A | — | — |
| 5JWP | Crystal structure of human FIH D201E variant in complex with Zn, alpha-ketoglutarate, and HIF1… | x-ray diffraction | B | — | 3 (best 0.75) |
| 5JWP | Crystal structure of human fih D201E variant in complex with zn, alpha-ketoglutarate, and HIF1… | x-ray diffraction | B | — | — |
| 5L9B | Hif prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 2-oxoglutarate (2OG) and hif-1ALPHA codd… | x-ray diffraction | C, D | AKG | — |
| 5L9V | Hif prolyl hydroxylase 2 (PHD2-R281C/P317C) cross-linked to hif-1ALPHA nodd-L397C/D412C and… | x-ray diffraction | C, D | OGA | — |
| 5LA9 | HIF prolyl hydroxylase 2 (PHD2-R281C/V314C) cross-linked to HIF-1alpha NODD-L397C/D412C and… | x-ray diffraction | C, D | OGA | — |
| 5LA9 | Hif prolyl hydroxylase 2 (PHD2-R281C/V314C) cross-linked to hif-1ALPHA nodd-L397C/D412C and… | x-ray diffraction | C, D | OGA | — |
| 5LAS | HIF prolyl hydroxylase 2 (PHD2-R281C/P317C/R396T) cross-linked to HIF-1alpha NODD-L397C/D412C and… | x-ray diffraction | C, D | OGA | — |
| 5LAS | Hif prolyl hydroxylase 2 (PHD2-R281C/P317C/R396T) cross-linked to hif- 1ALPHA nodd-L397C/D412C and… | x-ray diffraction | C, D | OGA | — |
| 6YW3 | HIF PROLYL HYDROXYLASE 2 (PHD2/ EGLN1) in complex with N-Oxalyl Glycine (NOG), HIF-1ALPHA CODD… | x-ray diffraction | S | OGA | — |
| 6YW3 | Hif prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with N-oxalyl glycine (nog), hif-1ALPHA codd… | x-ray diffraction | S | OGA | — |
| 7LVS | The cbp TAZ1 domain in complex with a CITED2-hif-1-alpha fusion peptide | x-ray diffraction | F | — | — |
| 7QGS | Crystal structure of P300 CH1 domain in complex with citif (a CITED2- hif-1ALPHA hybrid) | x-ray diffraction | B | — | — |
| Q16665 | AlphaFold monomer V2.0 prediction for hypoxia-inducible factor 1-alpha (Q16665) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4H6J chain A against the predicted model Q16665: TM-score 0.97, RMSD 0.76 Å
- 4H6J chain A against the predicted model Q16665: TM-score 0.97, RMSD 0.76 Å
- 3HQU chain S against the predicted model Q16665: TM-score 0.65, RMSD 0.38 Å
- 3HQU chain S against the predicted model Q16665: TM-score 0.65, RMSD 0.38 Å
- 2ILM chain S against the predicted model Q16665: TM-score 0.54, RMSD 0.99 Å
- 2ILM chain S against the predicted model Q16665: TM-score 0.54, RMSD 0.99 Å
- 7LVS chain F against the predicted model Q99967: TM-score 0.47, RMSD 3.17 Å
- 7QGS chain B against the predicted model Q99967: TM-score 0.44, RMSD 2.18 Å
- 3HQR chain S against the predicted model Q16665: TM-score 0.42, RMSD 1.77 Å
- 3HQR chain S against the predicted model Q16665: TM-score 0.42, RMSD 1.77 Å
Elsewhere
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