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UniProt P42026

NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (P42026)

NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (UniProt P42026), EC 1.6.5.3, 1.6.99.3: 43 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 125 pockets. Binding sites…

UniProt
P42026
Protein
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
EC
1.6.5.3, 1.6.99.3, 7.1.1.2
Experimental structures
43
Predicted models
1
Ligands
10
Pockets
125 · 27 records with a druggable one

Structures

44 records of P42026 in the MolNFT archive: 43 experimental, 1 predicted.

EntryTitleMethodChainsLigandsPockets
5LC5Structure of mammalian respiratory Complex I, class2electron microscopyBSF44 (best 0.87)
5LC5Structure of mammalian respiratory complex I, CLASS2electron microscopyBSF4—
5LDWStructure of mammalian respiratory Complex I, class1electron microscopyBSF4—
5LDWStructure of mammalian respiratory complex I, CLASS1electron microscopyBSF4—
5LDXStructure of mammalian respiratory complex I, CLASS3.electron microscopyBSF4—
5O31Mitochondrial complex I in the deactive stateelectron microscopyBSF44 (best 0.87)
5O31Mitochondrial complex I in the deactive stateelectron microscopyBSF4—
7DGQActivity optimized supercomplex state1electron microscopyDSF4, NAP4 (best 0.86)
7DGZActivity optimized complex I (closed form)electron microscopyDSF4, NAP—
7DH0Activity optimized complex I (open form)electron microscopyDSF4, NAP—
7DKFActivity optimized supercomplex state4electron microscopyD2SF4, NAP3 (best 0.87)
7QSDBovine complex I in the active state at 3.1 Aelectron microscopyBSF4, PC1, NDP4 (best 0.89)
7QSDBovine complex I in the active state at 3.1 aelectron microscopyBSF4, PC1, NDP—
7QSKBovine complex I in lipid nanodisc, active-Q10electron microscopyBSF4, PC1, U10, NDP—
7QSLBovine complex I in lipid nanodisc, active-apoelectron microscopyBSF4, PC1, NDP—
7QSMBovine complex I in lipid nanodisc, Deactive-ligand (composite)electron microscopyBPC1, SF4, NDP5 (best 0.87)
7QSMBovine complex I in lipid nanodisc, deactive-ligand (composite)electron microscopyBPC1, SF4, NDP—
7QSNBovine complex I in lipid nanodisc, deactive-apoelectron microscopyBPC1, SF4, NDP—
7QSOBovine complex I in lipid nanodisc, State 3 (Slack)electron microscopyBPC1, SF4, CHD, NDP—
7QSOBovine complex I in lipid nanodisc, state 3 (slack)electron microscopyBPC1, SF4, CHD, NDP—
7R41Bovine complex I in the presence of IM1761092, active class i (Composite map)electron microscopyBSF4, PC1, NDP4 (best 0.87)
7R43Bovine complex I in the presence of IM1761092, active class iii (Composite map)electron microscopyBSF4, PC1, NDP—
7R44Bovine complex I in the presence of IM1761092, active class iv (Composite map)electron microscopyBSF4, PC1, NDP5 (best 0.88)
7R45Bovine complex I in the presence of IM1761092, deactive class i (Composite map)electron microscopyBSF4, PC1, I49, NDP4 (best 0.87)
7R46Bovine complex I in the presence of IM1761092, deactive class ii (Composite map)electron microscopyB3PE, SF4, PC1, I49, NDP6 (best 0.87)
7R47Bovine complex I in the presence of IM1761092, deactive class iii (Composite map)electron microscopyBSF4, I49, NDP, PC1—
7R48Bovine complex I in the presence of IM1761092, deactive class iv (Composite map)electron microscopyBSF4, PC1, I49, NDP5 (best 0.88)
7R4CBovine complex I in the presence of IM1761092, deactive class v (Composite map)electron microscopyBSF4, PC1, I49, NDP5 (best 0.90)
7R4DBovine complex I in the presence of IM1761092, deactive class vi (Composite map)electron microscopyBSF4, PC1, NDP5 (best 0.86)
7R4FBovine complex I in the presence of IM1761092, slack class i (Composite map)electron microscopyBPC1, SF4, NDP5 (best 0.88)
7R4GBovine complex I in the presence of IM1761092, slack class ii (Composite map)electron microscopyBSF4, PC1, I49, NDP5 (best 0.88)
8Q0AInward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM.electron microscopyBSF4, PC1, PLC, NDP4 (best 0.88)
8Q0FInward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM.electron microscopyBPC1, SF4, PLC, NDP5 (best 0.88)
8Q0JInward-facing, slack proteoliposome complex I at 3.8 A. Initially purified in DDM.electron microscopyBPC1, SF4, NDP3 (best 0.88)
8Q0MOutward-facing, closed proteoliposome complex I at 3.1 A. Initially purified in DDM.electron microscopyBSF4, U10, PC1, NDP, PLC5 (best 0.89)
8Q1PInward-facing, open2 proteoliposome complex I at 2.9 A, after deactivation treatment. Initially…electron microscopyBPC1, SF4, PLC, NDP5 (best 0.88)
8Q1UInward-facing, open1 proteoliposome complex I at 3.3 A, after deactivation treatment. Initially…electron microscopyBSF4, PLC, U10, NDP, PC15 (best 0.86)
8Q1YOutward-facing, open2 proteoliposome complex I at 2.6 A, after deactivation treatment. Initially…electron microscopyBPC1, SF4, PLC, NDP, 3PE4 (best 0.86)
8Q25Outward-facing, open1 proteoliposome complex I at 2.8 A, after deactivation treatment. Initially…electron microscopyBSF4, PC1, U10, NDP6 (best 0.86)
8Q46Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG.electron microscopyBPC1, SF4, PLC, NDP5 (best 0.88)
8Q47Inward-facing, open1 proteoliposome complex I at 2.9 A. Initially purified in LMNG.electron microscopyBSF4, PC1, PLC, U10, NDP5 (best 0.87)
8Q49Outward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG.electron microscopyBPC1, SF4, PLC, FVH, 3PE4 (best 0.87)
8Q4AOutward-facing, open1 proteoliposome complex I at 2.6 A. Initially purified in LMNG.electron microscopyBSF4, PC1, U10, NDP5 (best 0.89)
P42026AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] iron-sulfur protein 7…predictedA—1 (best 0.32)

Ligands

  • SF4 · Iron/sulfur cluster · in 43 records
  • PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 32 records
  • NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 31 records
  • PLC · Diundecyl phosphatidyl choline · in 9 records
  • I49 · 1-carbamimidoyl-3-[2-(3-chloranyl-4-iodanyl-phenyl)ethyl]guanidine · in 6 records
  • U10 · Ubiquinone-10 · in 6 records
  • NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 4 records
  • 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 3 records
  • CHD · Cholic acid · in 2 records
  • FVH · [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R}, 5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate · in 1 record

Experiment against prediction

Elsewhere

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